Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis

Streptococcus pneumoniae and Neisseria meningitidis can cause sepsis and meningitis. Several risk factors for pneumococcal and meningococcal disease have been identified, but the cause of basic differences in susceptibility between individuals and populations is unknown. Single-nucleotide polymorphi...

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Veröffentlicht in:The Lancet infectious diseases Jg. 9; H. 1; S. 31 - 44
Hauptverfasser: Brouwer, Matthijs C, de Gans, Jan, Heckenberg, Sebastiaan GB, Zwinderman, Aeilko H, van der Poll, Tom, van de Beek, Diederik
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Elsevier Ltd 2009
Lancet Publishing Group
Elsevier Limited
Schlagworte:
Bacterial diseases
Bacterial diseases of the nervous system. Bacterial myositis
Biological and medical sciences
Genetic Predisposition to Disease
Human bacterial diseases
Humans
Infectious Disease
Infectious diseases
Medical sciences
Meningococcal Infections - genetics
Meningococcal Infections - immunology
Meningococcal Infections - microbiology
Pneumococcal Infections - genetics
Pneumococcal Infections - immunology
Pneumococcal Infections - microbiology
Polymorphism, Genetic
Risk factors
Staphylococcal infections, streptococcal infections, pneumococcal infections
Infection
Streptococcal infection
Bacteriosis
Genetic determinism
Pneumococcal infection
Bibliographic review
Meningococcal disease
ISSN:1473-3099, 1474-4457
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Zusammenfassung:Streptococcus pneumoniae and Neisseria meningitidis can cause sepsis and meningitis. Several risk factors for pneumococcal and meningococcal disease have been identified, but the cause of basic differences in susceptibility between individuals and populations is unknown. Single-nucleotide polymorphisms are thought to explain interindividual differences in susceptibility. New technologies provide the opportunity to study the genetic basis of susceptibility to these diseases. In recent years, several studies have been published on these polymorphisms in pneumococcal and meningococcal disease, many with apparently conflicting results. Herein we provide a systematic overview of all polymorphisms studied for a relation with susceptibility to pneumococcal and meningococcal disease. We also propose an initiative to pool genetic data on pneumococcal and meningococcal meningitis in one biobank.
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ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(08)70261-5