Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity

Conversion of fibroblasts into functional cardiomyocytes represents a potential means of restoring cardiac function after myocardial infarction, but so far this process remains inefficient and little is known about its molecular mechanisms. Here we show that DAPT, a classical Notch inhibitor, enhanc...

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Bibliographic Details
Published in:	Stem cell reports Vol. 8; no. 3; pp. 548 - 560
Main Authors:	Abad, Maria, Hashimoto, Hisayuki, Zhou, Huanyu, Morales, Maria Gabriela, Chen, Beibei, Bassel-Duby, Rhonda, Olson, Eric N.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 14.03.2017 Elsevier
Subjects:	Animals Calcium Signaling - drug effects cardiomyocytes Cell Differentiation cell-fate conversion Cellular Reprogramming - drug effects Cellular Reprogramming - genetics DAPT Diamines - pharmacology direct cellular reprogramming Electrophysiological Phenomena - drug effects Gene Expression Profiling Gene Expression Regulation, Developmental heart regeneration MEF2 Transcription Factors - metabolism Mice Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Notch signaling Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Receptors, Notch - metabolism regenerative medicine Sarcomeres - drug effects Sarcomeres - metabolism Signal Transduction Thiazoles - pharmacology Transcriptional Activation Transcriptome transdifferentiation cardiomyocytes direct cellular reprogramming heart regeneration Notch signaling regenerative medicine transdifferentiation cell-fate conversion DAPT
ISSN:	2213-6711, 2213-6711
Online Access:	Get full text
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