Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing

Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement of joint movement, lack of antibacterial function, and frequent replacements. Hydrogels have been considered as good...

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Vydáno v:Advanced science Ročník 8; číslo 8; s. 2003627 - n/a
Hlavní autoři: Yang, Zifeng, Huang, Rongkang, Zheng, Bingna, Guo, Wentai, Li, Chuangkun, He, Wenyi, Wei, Yingqi, Du, Yang, Wang, Huaiming, Wu, Dingcai, Wang, Hui
Médium: Journal Article
Jazyk:angličtina
Vydáno: Germany John Wiley & Sons, Inc 01.04.2021
John Wiley and Sons Inc
Wiley
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ISSN:2198-3844, 2198-3844
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Abstract Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement of joint movement, lack of antibacterial function, and frequent replacements. Hydrogels have been considered as good candidates for wound dressing because of their good flexibility and biocompatibility. Nevertheless, the adhesive, mechanical, and antibacterial properties of conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer brushes have rigid BC backbones to enhance mechanical property of hydrogels, realizing high tensile strength (21–51 kPa), large tensile strain (899–1047%), and ideal compressive property. Positively charged quaternary ammonium groups of tethered polymer brushes provide long‐lasting antibacterial property to hydrogels and promote crawling and proliferation of negatively charged epidermis cells. Moreover, the hydrogels are rich in catechol groups and capable of adhering to various surfaces, meeting adhesive demand of large movement for special areas. With the above merits, the hydrogels demonstrate less inflammatory response and faster healing speed for in vivo wound healing on rats. Therefore, the multifunctional hydrogels show stable covering, little displacement, long‐lasting antibacteria, and fast wound healing, demonstrating promise in wound dressing. A new class of highly stretchable, adhesive, biocompatible, and antibacterial hydrogel dressing is designed and prepared by synergizing biocompatible polyacrylamide hydrogel scaffold, biological adhesive polydopamine, and antibacterial polymer brush grafted from bacterial cellulose nanofibers.
AbstractList Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement of joint movement, lack of antibacterial function, and frequent replacements. Hydrogels have been considered as good candidates for wound dressing because of their good flexibility and biocompatibility. Nevertheless, the adhesive, mechanical, and antibacterial properties of conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer brushes have rigid BC backbones to enhance mechanical property of hydrogels, realizing high tensile strength (21–51 kPa), large tensile strain (899–1047%), and ideal compressive property. Positively charged quaternary ammonium groups of tethered polymer brushes provide long‐lasting antibacterial property to hydrogels and promote crawling and proliferation of negatively charged epidermis cells. Moreover, the hydrogels are rich in catechol groups and capable of adhering to various surfaces, meeting adhesive demand of large movement for special areas. With the above merits, the hydrogels demonstrate less inflammatory response and faster healing speed for in vivo wound healing on rats. Therefore, the multifunctional hydrogels show stable covering, little displacement, long‐lasting antibacteria, and fast wound healing, demonstrating promise in wound dressing. A new class of highly stretchable, adhesive, biocompatible, and antibacterial hydrogel dressing is designed and prepared by synergizing biocompatible polyacrylamide hydrogel scaffold, biological adhesive polydopamine, and antibacterial polymer brush grafted from bacterial cellulose nanofibers.
Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement of joint movement, lack of antibacterial function, and frequent replacements. Hydrogels have been considered as good candidates for wound dressing because of their good flexibility and biocompatibility. Nevertheless, the adhesive, mechanical, and antibacterial properties of conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer brushes have rigid BC backbones to enhance mechanical property of hydrogels, realizing high tensile strength (21–51 kPa), large tensile strain (899–1047%), and ideal compressive property. Positively charged quaternary ammonium groups of tethered polymer brushes provide long‐lasting antibacterial property to hydrogels and promote crawling and proliferation of negatively charged epidermis cells. Moreover, the hydrogels are rich in catechol groups and capable of adhering to various surfaces, meeting adhesive demand of large movement for special areas. With the above merits, the hydrogels demonstrate less inflammatory response and faster healing speed for in vivo wound healing on rats. Therefore, the multifunctional hydrogels show stable covering, little displacement, long‐lasting antibacteria, and fast wound healing, demonstrating promise in wound dressing. A new class of highly stretchable, adhesive, biocompatible, and antibacterial hydrogel dressing is designed and prepared by synergizing biocompatible polyacrylamide hydrogel scaffold, biological adhesive polydopamine, and antibacterial polymer brush grafted from bacterial cellulose nanofibers.
Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement of joint movement, lack of antibacterial function, and frequent replacements. Hydrogels have been considered as good candidates for wound dressing because of their good flexibility and biocompatibility. Nevertheless, the adhesive, mechanical, and antibacterial properties of conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer brushes have rigid BC backbones to enhance mechanical property of hydrogels, realizing high tensile strength (21-51 kPa), large tensile strain (899-1047%), and ideal compressive property. Positively charged quaternary ammonium groups of tethered polymer brushes provide long-lasting antibacterial property to hydrogels and promote crawling and proliferation of negatively charged epidermis cells. Moreover, the hydrogels are rich in catechol groups and capable of adhering to various surfaces, meeting adhesive demand of large movement for special areas. With the above merits, the hydrogels demonstrate less inflammatory response and faster healing speed for in vivo wound healing on rats. Therefore, the multifunctional hydrogels show stable covering, little displacement, long-lasting antibacteria, and fast wound healing, demonstrating promise in wound dressing.
Abstract Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement of joint movement, lack of antibacterial function, and frequent replacements. Hydrogels have been considered as good candidates for wound dressing because of their good flexibility and biocompatibility. Nevertheless, the adhesive, mechanical, and antibacterial properties of conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer brushes have rigid BC backbones to enhance mechanical property of hydrogels, realizing high tensile strength (21–51 kPa), large tensile strain (899–1047%), and ideal compressive property. Positively charged quaternary ammonium groups of tethered polymer brushes provide long‐lasting antibacterial property to hydrogels and promote crawling and proliferation of negatively charged epidermis cells. Moreover, the hydrogels are rich in catechol groups and capable of adhering to various surfaces, meeting adhesive demand of large movement for special areas. With the above merits, the hydrogels demonstrate less inflammatory response and faster healing speed for in vivo wound healing on rats. Therefore, the multifunctional hydrogels show stable covering, little displacement, long‐lasting antibacteria, and fast wound healing, demonstrating promise in wound dressing.
Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement of joint movement, lack of antibacterial function, and frequent replacements. Hydrogels have been considered as good candidates for wound dressing because of their good flexibility and biocompatibility. Nevertheless, the adhesive, mechanical, and antibacterial properties of conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer brushes have rigid BC backbones to enhance mechanical property of hydrogels, realizing high tensile strength (21–51 kPa), large tensile strain (899–1047%), and ideal compressive property. Positively charged quaternary ammonium groups of tethered polymer brushes provide long‐lasting antibacterial property to hydrogels and promote crawling and proliferation of negatively charged epidermis cells. Moreover, the hydrogels are rich in catechol groups and capable of adhering to various surfaces, meeting adhesive demand of large movement for special areas. With the above merits, the hydrogels demonstrate less inflammatory response and faster healing speed for in vivo wound healing on rats. Therefore, the multifunctional hydrogels show stable covering, little displacement, long‐lasting antibacteria, and fast wound healing, demonstrating promise in wound dressing.
Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement of joint movement, lack of antibacterial function, and frequent replacements. Hydrogels have been considered as good candidates for wound dressing because of their good flexibility and biocompatibility. Nevertheless, the adhesive, mechanical, and antibacterial properties of conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer brushes have rigid BC backbones to enhance mechanical property of hydrogels, realizing high tensile strength (21-51 kPa), large tensile strain (899-1047%), and ideal compressive property. Positively charged quaternary ammonium groups of tethered polymer brushes provide long-lasting antibacterial property to hydrogels and promote crawling and proliferation of negatively charged epidermis cells. Moreover, the hydrogels are rich in catechol groups and capable of adhering to various surfaces, meeting adhesive demand of large movement for special areas. With the above merits, the hydrogels demonstrate less inflammatory response and faster healing speed for in vivo wound healing on rats. Therefore, the multifunctional hydrogels show stable covering, little displacement, long-lasting antibacteria, and fast wound healing, demonstrating promise in wound dressing.Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement of joint movement, lack of antibacterial function, and frequent replacements. Hydrogels have been considered as good candidates for wound dressing because of their good flexibility and biocompatibility. Nevertheless, the adhesive, mechanical, and antibacterial properties of conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer brushes have rigid BC backbones to enhance mechanical property of hydrogels, realizing high tensile strength (21-51 kPa), large tensile strain (899-1047%), and ideal compressive property. Positively charged quaternary ammonium groups of tethered polymer brushes provide long-lasting antibacterial property to hydrogels and promote crawling and proliferation of negatively charged epidermis cells. Moreover, the hydrogels are rich in catechol groups and capable of adhering to various surfaces, meeting adhesive demand of large movement for special areas. With the above merits, the hydrogels demonstrate less inflammatory response and faster healing speed for in vivo wound healing on rats. Therefore, the multifunctional hydrogels show stable covering, little displacement, long-lasting antibacteria, and fast wound healing, demonstrating promise in wound dressing.
Author Huang, Rongkang
He, Wenyi
Yang, Zifeng
Zheng, Bingna
Wang, Hui
Wang, Huaiming
Li, Chuangkun
Wei, Yingqi
Du, Yang
Wu, Dingcai
Guo, Wentai
AuthorAffiliation 2 PCFM Lab and GDHPRC Lab School of Chemistry Sun Yat‐sen University Guangzhou 510275 P. R. China
1 Department of Colorectal Surgery The Sixth Affiliated Hospital, Sun Yat‐sen University, Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases Guangzhou 510655 P. R. China
AuthorAffiliation_xml – name: 2 PCFM Lab and GDHPRC Lab School of Chemistry Sun Yat‐sen University Guangzhou 510275 P. R. China
– name: 1 Department of Colorectal Surgery The Sixth Affiliated Hospital, Sun Yat‐sen University, Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases Guangzhou 510655 P. R. China
Author_xml – sequence: 1
  givenname: Zifeng
  surname: Yang
  fullname: Yang, Zifeng
  organization: Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases
– sequence: 2
  givenname: Rongkang
  surname: Huang
  fullname: Huang, Rongkang
  organization: Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases
– sequence: 3
  givenname: Bingna
  surname: Zheng
  fullname: Zheng, Bingna
  email: zhengbn3@mail.sysu.edu.cn
  organization: Sun Yat‐sen University
– sequence: 4
  givenname: Wentai
  surname: Guo
  fullname: Guo, Wentai
  organization: Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases
– sequence: 5
  givenname: Chuangkun
  surname: Li
  fullname: Li, Chuangkun
  organization: Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases
– sequence: 6
  givenname: Wenyi
  surname: He
  fullname: He, Wenyi
  organization: Sun Yat‐sen University
– sequence: 7
  givenname: Yingqi
  surname: Wei
  fullname: Wei, Yingqi
  organization: Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases
– sequence: 8
  givenname: Yang
  surname: Du
  fullname: Du, Yang
  organization: Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases
– sequence: 9
  givenname: Huaiming
  surname: Wang
  fullname: Wang, Huaiming
  organization: Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases
– sequence: 10
  givenname: Dingcai
  orcidid: 0000-0003-1396-0097
  surname: Wu
  fullname: Wu, Dingcai
  email: wudc@mail.sysu.edu.cn
  organization: Sun Yat‐sen University
– sequence: 11
  givenname: Hui
  surname: Wang
  fullname: Wang, Hui
  email: wang89@mail.sysu.edu.cn
  organization: Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33898178$$D View this record in MEDLINE/PubMed
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Keywords stretchable materials
wound healing
adhesive
antibacterial dressings
hydrogel dressings
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Snippet Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint...
Abstract Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete...
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StartPage 2003627
SubjectTerms Adhesion
adhesive
Adhesives
antibacterial dressings
Biocompatibility
Biomedical materials
Cotton
Dopamine
Fourier transforms
hydrogel dressings
Hydrogels
Polymerization
Skin
Spectrum analysis
stretchable materials
Wound healing
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Title Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fadvs.202003627
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