Engineering a Smart Agent for Enhanced Immunotherapy Effect by Simultaneously Blocking PD‐L1 and CTLA‐4

Combinations of immune checkpoint therapies show encouraging results in the treatment of many human cancers. However, the higher costs and greater side effects of such combinations compared with single‐agent immunotherapies limit their further applications. In this work, a novel smart agent, KN046@1...

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Veröffentlicht in:	Advanced science Jg. 8; H. 20; S. e2102500 - n/a
Hauptverfasser:	Jiang, Chunjuan, Zhang, Le, Xu, Xiaoping, Qi, Ming, Zhang, Jianping, He, Simin, Tian, Qiwei, Song, Shaoli
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Germany John Wiley & Sons, Inc 01.10.2021 John Wiley and Sons Inc Wiley
Schlagworte:	19F MRI Animals Antibodies Antibodies, Bispecific - chemistry Antibodies, Bispecific - immunology Antibodies, Bispecific - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - genetics B7-H1 Antigen - immunology Cancer Cell Line, Tumor Cell Proliferation - drug effects CTLA-4 Antigen - antagonists & inhibitors CTLA-4 Antigen - genetics CTLA-4 Antigen - immunology Efficiency FDA approval Fluorine granzyme B probes Humans Immune Checkpoint Inhibitors - pharmacology immunotherapies Immunotherapy Melanoma Mice Nanoparticles Neoplasms - genetics Neoplasms - immunology Neoplasms - therapy Physiology positron emission tomography/computed tomography imaging Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - pharmacology Scanning electron microscopy Single-Domain Antibodies - chemistry Single-Domain Antibodies - immunology Single-Domain Antibodies - pharmacology Tumors Xenograft Model Antitumor Assays ZIF‐8 immunotherapies granzyme B probes positron emission tomography/computed tomography imaging ZIF-8 19F MRI
ISSN:	2198-3844, 2198-3844
Online-Zugang:	Volltext
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