Calpain inhibition in a transgenic model of calpastatin overexpression facilitates reversal of myocardial hypertrophy

Aims It was recently demonstrated that the intracellular signalling phosphatase calcineurin is subject to cleavage by the protease calpain, resulting in a truncated calcineurin fragment that is a strong inductor of myocardial hypertrophy. We now address the question of whether inhibition of calpain...

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Bibliographic Details
Published in:	ESC Heart Failure Vol. 12; no. 3; pp. 2256 - 2266
Main Authors:	Sachse, Gregor, Tennigkeit, Johanna, Pagonas, Nikolaos, Hillmeister, Philipp, Buschmann, Ivo, Czolbe, Martin, Nordbeck, Peter, Schmitt, Joachim, Patschan, Daniel, Ritter, Oliver
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01.06.2025 John Wiley and Sons Inc Wiley
Subjects:	Angiotensin II Animals Antibodies Calcineurin - metabolism Calcium-Binding Proteins - biosynthesis Calcium-Binding Proteins - genetics Calpain - antagonists & inhibitors Calpain - metabolism Cardiomegaly - genetics Cardiomegaly - metabolism Cardiomyocytes Cloning Disease Models, Animal Heart failure Magnetic resonance imaging Mice Mice, Transgenic Myocardial hypertrophy Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Original Proteins Signal transduction Statistical analysis Transgenic animals United States > US Germany Heart failure Signal transduction Myocardial hypertrophy
ISSN:	2055-5822, 2055-5822
Online Access:	Get full text
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