Calpain inhibition in a transgenic model of calpastatin overexpression facilitates reversal of myocardial hypertrophy

Aims It was recently demonstrated that the intracellular signalling phosphatase calcineurin is subject to cleavage by the protease calpain, resulting in a truncated calcineurin fragment that is a strong inductor of myocardial hypertrophy. We now address the question of whether inhibition of calpain...

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