A brief-review of the risk factors for covid-19 severity

The World Health Organization has emphasized that one of the most important questions to address regarding the covid-19 pandemic is to understand risk factors for disease severity. We conducted a brief review that synthesizes the available evidence and provides a judgment on the consistency of the a...

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Vydáno v:Revista de saúde pública Ročník 54; s. 60
Hlavní autoři: Rod, J. E., Oviedo-Trespalacios, Oscar, Cortes-Ramirez, Javier
Médium: Journal Article
Jazyk:angličtina
Vydáno: Brazil Faculdade de Saúde Pública da Universidade de São Paulo 01.01.2020
Universidade de São Paulo
Témata:
Betacoronavirus
Brief Communication
Coronavirus Infections - epidemiology
COVID-19
Diabetes Complications
fatal outcome
Female
Humans
Male
Pandemics
Pneumonia, Viral - epidemiology
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
review
Risk Assessment
Risk Factors
SARS-CoV-2
Severity of Illness Index
SOCIOLOGY
Coronavirus Infections, epidemiology
Review
Risk Factors
Fatal Outcome
ISSN:0034-8910, 1518-8787, 1518-8787
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Shrnutí:The World Health Organization has emphasized that one of the most important questions to address regarding the covid-19 pandemic is to understand risk factors for disease severity. We conducted a brief review that synthesizes the available evidence and provides a judgment on the consistency of the association between risk factors and a composite end-point of severe-fatal covid-19. Additionally, we also conducted a comparability analysis of risk factors across 17 studies. We found evidence supporting a total of 60 predictors for disease severity, of which seven were deemed of high consistency, 40 of medium and 13 of low. Among the factors with high consistency of association, we found age, C-reactive protein, D-dimer, albumin, body temperature, SOFA score and diabetes. The results suggest that diabetes might be the most consistent comorbidity predicting disease severity and that future research should carefully consider the comparability of reporting cases, factors, and outcomes along the different stages of the natural history of covid-19.
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Conflict of Interest: The authors declare no conflict of interest.
Authors’ Contribution: Study design: JER, OOT, JCR. Data collection, analysis and interpretation: JER, OOT, JCR. Writing of the manuscript and approval of the final version: JER, OOT, JCR. Public responsibility for the content of the article: JER, OOT, JCR.
ISSN:0034-8910
1518-8787
1518-8787
DOI:10.11606/s1518-8787.2020054002481