Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial

Effective targeting of somatic cancer mutations to enhance the efficacy of cancer immunotherapy requires an individualized approach. Autogene cevumeran is a uridine messenger RNA lipoplex-based individualized neoantigen-specific immunotherapy designed from tumor-specific somatic mutation data obtain...

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Vydáno v:	Nature medicine Ročník 31; číslo 1; s. 152
Hlavní autoři:	Lopez, Juanita, Powles, Thomas, Braiteh, Fadi, Siu, Lillian L, LoRusso, Patricia, Friedman, Claire F, Balmanoukian, Ani S, Gordon, Michael, Yachnin, Jeffrey, Rottey, Sylvie, Karydis, Ioannis, Fisher, George A, Schmidt, Marcus, Schuler, Martin, Sullivan, Ryan J, Burris, Howard A, Galvao, Vladimir, Henick, Brian S, Dirix, Luc, Jaeger, Dirk, Ott, Patrick A, Wong, Kit Man, Jerusalem, Guy, Schiza, Aglaia, Fong, Lawrence, Steeghs, Neeltje, Leidner, Rom S, Rittmeyer, Achim, Laurie, Scott A, Gort, Eelke, Aljumaily, Raid, Melero, Ignacio, Sabado, Rachel L, Rhee, Ina, Mancuso, Michael R, Muller, Lars, Fine, Gregg D, Yadav, Mahesh, Kim, Leesun, Leveque, Vincent J P, Robert, Alberto, Darwish, Martine, Qi, Ting, Zhu, Jiawen, Zhang, Jingbin, Twomey, Patrick, Rao, Gautham K, Low, Donald W, Petry, Chris, Lo, Amy A, Schartner, Jill M, Delamarre, Lélia, Mellman, Ira, Löwer, Martin, Müller, Felicitas, Derhovanessian, Evelyna, Cortini, Andrea, Manning, Luisa, Maurus, Daniel, Brachtendorf, Sebastian, Lörks, Verena, Omokoko, Tana, Godehardt, Eva, Becker, Dirk, Hawner, Christine, Wallrapp, Christine, Albrecht, Christian, Kröner, Christoph, Tadmor, Arbel D, Diekmann, Jan, Vormehr, Mathias, Jork, Anette, Paruzynski, Anna, Lang, Maren, Blake, Jonathon, Hennig, Oliver, Kuhn, Andreas N, Sahin, Ugur, Türeci, Özlem, Camidge, D Ross
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.01.2025
Témata:	Adult Aged Aged, 80 and over Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - therapeutic use Antigens, Neoplasm - immunology Antineoplastic Combined Chemotherapy Protocols - therapeutic use CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Female Humans Immunotherapy - methods Male Middle Aged Neoplasms - drug therapy Neoplasms - genetics Neoplasms - immunology Neoplasms - pathology Neoplasms - therapy
ISSN:	1546-170X, 1546-170X
On-line přístup:	Zjistit podrobnosti o přístupu
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