A novel role for Friend of GATA1 (FOG-1) in regulating cholesterol transport in murine erythropoiesis

Friend of GATA1 (FOG-1) is an essential transcriptional co-factor of the master erythroid transcription factor GATA1. The knockout of the Zfpm1 gene, coding for FOG-1, results in early embryonic lethality due to anemia in mice, similar to the embryonic lethal phenotype of the Gata1 gene knockout. Ho...

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Veröffentlicht in:	PLoS genetics Jg. 21; H. 3; S. e1011617
Hauptverfasser:	Roussis, Ioannis-Marios, Pearton, David J., Niazi, Umar, Tsaknakis, Grigorios, Papadopoulos, Giorgio L., Cook, Riley, Saqi, Mansoor, Ragoussis, Jiannis, Strouboulis, John
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.03.2025 Public Library of Science (PLoS)
Schlagworte:	ABCA1 protein Anemia Animals ATP Binding Cassette Transporter 1 - genetics ATP Binding Cassette Transporter 1 - metabolism ATP-binding protein Biological transport Biological Transport - genetics Biology and Life Sciences Cell cycle Cell differentiation Cell Differentiation - genetics Cholesterol Cholesterol - metabolism Cloning CRISPR CRISPR-Cas Systems Embryos Erythropoiesis Erythropoiesis - genetics Flow cytometry Fluidity GATA-1 protein GATA1 Transcription Factor - genetics GATA1 Transcription Factor - metabolism Gene expression Gene regulation Gene silencing Genetic aspects Genotype & phenotype Homeostasis Lethality Membrane fluidity Mice Mice, Knockout Phenotypes Physiological aspects Proteins Research and Analysis Methods Sterol Regulatory Element Binding Protein 2 - genetics Sterol Regulatory Element Binding Protein 2 - metabolism Transcription Factors - genetics Transcription Factors - metabolism United Kingdom
ISSN:	1553-7404, 1553-7390, 1553-7404
Online-Zugang:	Volltext
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