A novel role for Friend of GATA1 (FOG-1) in regulating cholesterol transport in murine erythropoiesis
Friend of GATA1 (FOG-1) is an essential transcriptional co-factor of the master erythroid transcription factor GATA1. The knockout of the Zfpm1 gene, coding for FOG-1, results in early embryonic lethality due to anemia in mice, similar to the embryonic lethal phenotype of the Gata1 gene knockout. Ho...
Uložené v:
| Vydané v: | PLoS genetics Ročník 21; číslo 3; s. e1011617 |
|---|---|
| Hlavní autori: | , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
United States
Public Library of Science
01.03.2025
Public Library of Science (PLoS) |
| Predmet: | |
| ISSN: | 1553-7404, 1553-7390, 1553-7404 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Friend of GATA1 (FOG-1) is an essential transcriptional co-factor of the master erythroid transcription factor GATA1. The knockout of the Zfpm1 gene, coding for FOG-1, results in early embryonic lethality due to anemia in mice, similar to the embryonic lethal phenotype of the Gata1 gene knockout. However, a detailed molecular analysis of the Zfpm1 knockout phenotype in erythropoiesis is presently incomplete. To this end, we used CRISPR/Cas9 to knockout Zfpm1 in mouse erythroleukemic (MEL) cells. Phenotypic characterization of DMSO-induced terminal erythroid differentiation showed that the Zfpm1 knockout MEL cells did not progress past the proerythroblast stage of differentiation. Expression profiling of the Zfpm1 knockout MEL cells by RNAseq showed a lack of up-regulation of erythroid-related gene expression profiles. Bioinformatic analysis highlighted cholesterol transport as a pathway affected in the Zfpm1 knockout cells. Moreover, we show that the cholesterol transporters Abca1 and Ldlr fail to be repressed during erythroid differentiation in Zfpm1 knockout cells, resulting in higher intracellular lipid levels and higher membrane fluidity. We also show that in FOG-1 knockout cells, the nuclear levels of SREBP2, a key transcriptional regulator of cholesterol biosynthesis and transport, are markedly increased. On the basis of these findings we propose that FOG-1 (and, potentially, GATA1) regulate cholesterol homeostasis during erythroid differentiation directly through the down regulation of cholesterol transport genes and indirectly, through the repression of the SREBP2 transcriptional activator of cholesterol homeostasis. Taken together, our work provides a molecular basis for understanding FOG-1 functions in erythropoiesis and reveals a novel role for FOG-1 in cholesterol transport. |
|---|---|
| AbstractList | Friend of GATA1 (FOG-1) is an essential transcriptional co-factor of the master erythroid transcription factor GATA1. The knockout of the Zfpm1 gene, coding for FOG-1, results in early embryonic lethality due to anemia in mice, similar to the embryonic lethal phenotype of the Gata1 gene knockout. However, a detailed molecular analysis of the Zfpm1 knockout phenotype in erythropoiesis is presently incomplete. To this end, we used CRISPR/Cas9 to knockout Zfpm1 in mouse erythroleukemic (MEL) cells. Phenotypic characterization of DMSO-induced terminal erythroid differentiation showed that the Zfpm1 knockout MEL cells did not progress past the proerythroblast stage of differentiation. Expression profiling of the Zfpm1 knockout MEL cells by RNAseq showed a lack of up-regulation of erythroid-related gene expression profiles. Bioinformatic analysis highlighted cholesterol transport as a pathway affected in the Zfpm1 knockout cells. Moreover, we show that the cholesterol transporters Abca1 and Ldlr fail to be repressed during erythroid differentiation in Zfpm1 knockout cells, resulting in higher intracellular lipid levels and higher membrane fluidity. We also show that in FOG-1 knockout cells, the nuclear levels of SREBP2, a key transcriptional regulator of cholesterol biosynthesis and transport, are markedly increased. On the basis of these findings we propose that FOG-1 (and, potentially, GATA1) regulate cholesterol homeostasis during erythroid differentiation directly through the down regulation of cholesterol transport genes and indirectly, through the repression of the SREBP2 transcriptional activator of cholesterol homeostasis. Taken together, our work provides a molecular basis for understanding FOG-1 functions in erythropoiesis and reveals a novel role for FOG-1 in cholesterol transport. Friend of GATA1 (FOG-1) is an essential transcriptional co-factor of the master erythroid transcription factor GATA1. The knockout of the Zfpm1 gene, coding for FOG-1, results in early embryonic lethality due to anemia in mice, similar to the embryonic lethal phenotype of the Gata1 gene knockout. However, a detailed molecular analysis of the Zfpm1 knockout phenotype in erythropoiesis is presently incomplete. To this end, we used CRISPR/Cas9 to knockout Zfpm1 in mouse erythroleukemic (MEL) cells. Phenotypic characterization of DMSO-induced terminal erythroid differentiation showed that the Zfpm1 knockout MEL cells did not progress past the proerythroblast stage of differentiation. Expression profiling of the Zfpm1 knockout MEL cells by RNAseq showed a lack of up-regulation of erythroid-related gene expression profiles. Bioinformatic analysis highlighted cholesterol transport as a pathway affected in the Zfpm1 knockout cells. Moreover, we show that the cholesterol transporters Abca1 and Ldlr fail to be repressed during erythroid differentiation in Zfpm1 knockout cells, resulting in higher intracellular lipid levels and higher membrane fluidity. We also show that in FOG-1 knockout cells, the nuclear levels of SREBP2, a key transcriptional regulator of cholesterol biosynthesis and transport, are markedly increased. On the basis of these findings we propose that FOG-1 (and, potentially, GATA1) regulate cholesterol homeostasis during erythroid differentiation directly through the down regulation of cholesterol transport genes and indirectly, through the repression of the SREBP2 transcriptional activator of cholesterol homeostasis. Taken together, our work provides a molecular basis for understanding FOG-1 functions in erythropoiesis and reveals a novel role for FOG-1 in cholesterol transport. Friend of GATA1 (FOG-1) is an essential transcriptional co-factor of the master erythroid transcription factor GATA1. The knockout of the Zfpm1 gene, coding for FOG-1, results in early embryonic lethality due to anemia in mice, similar to the embryonic lethal phenotype of the Gata1 gene knockout. However, a detailed molecular analysis of the Zfpm1 knockout phenotype in erythropoiesis is presently incomplete. To this end, we used CRISPR/Cas9 to knockout Zfpm1 in mouse erythroleukemic (MEL) cells. Phenotypic characterization of DMSO-induced terminal erythroid differentiation showed that the Zfpm1 knockout MEL cells did not progress past the proerythroblast stage of differentiation. Expression profiling of the Zfpm1 knockout MEL cells by RNAseq showed a lack of up-regulation of erythroid-related gene expression profiles. Bioinformatic analysis highlighted cholesterol transport as a pathway affected in the Zfpm1 knockout cells. Moreover, we show that the cholesterol transporters Abca1 and Ldlr fail to be repressed during erythroid differentiation in Zfpm1 knockout cells, resulting in higher intracellular lipid levels and higher membrane fluidity. We also show that in FOG-1 knockout cells, the nuclear levels of SREBP2, a key transcriptional regulator of cholesterol biosynthesis and transport, are markedly increased. On the basis of these findings we propose that FOG-1 (and, potentially, GATA1) regulate cholesterol homeostasis during erythroid differentiation directly through the down regulation of cholesterol transport genes and indirectly, through the repression of the SREBP2 transcriptional activator of cholesterol homeostasis. Taken together, our work provides a molecular basis for understanding FOG-1 functions in erythropoiesis and reveals a novel role for FOG-1 in cholesterol transport.Friend of GATA1 (FOG-1) is an essential transcriptional co-factor of the master erythroid transcription factor GATA1. The knockout of the Zfpm1 gene, coding for FOG-1, results in early embryonic lethality due to anemia in mice, similar to the embryonic lethal phenotype of the Gata1 gene knockout. However, a detailed molecular analysis of the Zfpm1 knockout phenotype in erythropoiesis is presently incomplete. To this end, we used CRISPR/Cas9 to knockout Zfpm1 in mouse erythroleukemic (MEL) cells. Phenotypic characterization of DMSO-induced terminal erythroid differentiation showed that the Zfpm1 knockout MEL cells did not progress past the proerythroblast stage of differentiation. Expression profiling of the Zfpm1 knockout MEL cells by RNAseq showed a lack of up-regulation of erythroid-related gene expression profiles. Bioinformatic analysis highlighted cholesterol transport as a pathway affected in the Zfpm1 knockout cells. Moreover, we show that the cholesterol transporters Abca1 and Ldlr fail to be repressed during erythroid differentiation in Zfpm1 knockout cells, resulting in higher intracellular lipid levels and higher membrane fluidity. We also show that in FOG-1 knockout cells, the nuclear levels of SREBP2, a key transcriptional regulator of cholesterol biosynthesis and transport, are markedly increased. On the basis of these findings we propose that FOG-1 (and, potentially, GATA1) regulate cholesterol homeostasis during erythroid differentiation directly through the down regulation of cholesterol transport genes and indirectly, through the repression of the SREBP2 transcriptional activator of cholesterol homeostasis. Taken together, our work provides a molecular basis for understanding FOG-1 functions in erythropoiesis and reveals a novel role for FOG-1 in cholesterol transport. Friend of GATA1 (FOG-1) is an essential transcriptional co-factor of the master erythroid transcription factor GATA1. The knockout of the Zfpm1 gene, coding for FOG-1, results in early embryonic lethality due to anemia in mice, similar to the embryonic lethal phenotype of the Gata1 gene knockout. However, a detailed molecular analysis of the Zfpm1 knockout phenotype in erythropoiesis is presently incomplete. To this end, we used CRISPR/Cas9 to knockout Zfpm1 in mouse erythroleukemic (MEL) cells. Phenotypic characterization of DMSO-induced terminal erythroid differentiation showed that the Zfpm1 knockout MEL cells did not progress past the proerythroblast stage of differentiation. Expression profiling of the Zfpm1 knockout MEL cells by RNAseq showed a lack of up-regulation of erythroid-related gene expression profiles. Bioinformatic analysis highlighted cholesterol transport as a pathway affected in the Zfpm1 knockout cells. Moreover, we show that the cholesterol transporters Abca1 and Ldlr fail to be repressed during erythroid differentiation in Zfpm1 knockout cells, resulting in higher intracellular lipid levels and higher membrane fluidity. We also show that in FOG-1 knockout cells, the nuclear levels of SREBP2, a key transcriptional regulator of cholesterol biosynthesis and transport, are markedly increased. On the basis of these findings we propose that FOG-1 (and, potentially, GATA1) regulate cholesterol homeostasis during erythroid differentiation directly through the down regulation of cholesterol transport genes and indirectly, through the repression of the SREBP2 transcriptional activator of cholesterol homeostasis. Taken together, our work provides a molecular basis for understanding FOG-1 functions in erythropoiesis and reveals a novel role for FOG-1 in cholesterol transport. Erythropoiesis is the process by which the oxygen-carrying red blood cells (RBCs) are produced in our body. Friend of GATA1 (FOG-1) and its partner GATA1, are key molecules that control erythropoiesis by coordinating the activity of the many genes that are required for the production of functional RBCs. To obtain more insight as to how FOG-1 works in erythropoiesis, we knocked out the FOG-1 gene in mouse immature red cells and asked the question of how this affects RBC production in a Petri dish. As expected, we found that the FOG-1 knockout cells cannot progress to produce mature red cells. By analyzing the differences in the RNA profiles between the normal and the FOG-1 knockout cells, we saw for the first time that proteins called cholesterol transporters were affected, in that they were not turned off, as would be the case in the normal cells. Cholesterol is a naturally occurring fat-like substance utilized in the cell membrane to enhance cell flexibility. This is a key RBC property that allows them to squeeze through tight spaces around the body. Our findings are important in understanding (i) key FOG-1 functions in RBC production and (ii) cholesterol functions in RBCs. |
| Audience | Academic |
| Author | Saqi, Mansoor Roussis, Ioannis-Marios Papadopoulos, Giorgio L. Cook, Riley Niazi, Umar Ragoussis, Jiannis Tsaknakis, Grigorios Pearton, David J. Strouboulis, John |
| AuthorAffiliation | 2 Department of Biology, University of Crete, Heraklion, Crete, Greece 4 Institute of Molecular Biology and Biotechnology, Foundation for Research & Technology Hellas, Heraklion, Crete, Greece 3 Translational Bioinformatics, National Institute for Health Research Biomedical Centre, Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, London, United Kingdom 5 Bone Marrow Failure Group, Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom 6 Department of Human Genetics, McGill University and McGill Genome Centre, Montreal, Quebec, Canada Indian Institute of Science Education and Research Mohali, INDIA 1 Red Cell Haematology Lab, Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom |
| AuthorAffiliation_xml | – name: 6 Department of Human Genetics, McGill University and McGill Genome Centre, Montreal, Quebec, Canada – name: Indian Institute of Science Education and Research Mohali, INDIA – name: 2 Department of Biology, University of Crete, Heraklion, Crete, Greece – name: 5 Bone Marrow Failure Group, Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom – name: 1 Red Cell Haematology Lab, Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom – name: 4 Institute of Molecular Biology and Biotechnology, Foundation for Research & Technology Hellas, Heraklion, Crete, Greece – name: 3 Translational Bioinformatics, National Institute for Health Research Biomedical Centre, Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, London, United Kingdom |
| Author_xml | – sequence: 1 givenname: Ioannis-Marios surname: Roussis fullname: Roussis, Ioannis-Marios – sequence: 2 givenname: David J. orcidid: 0000-0001-8747-7554 surname: Pearton fullname: Pearton, David J. – sequence: 3 givenname: Umar orcidid: 0000-0001-7176-8883 surname: Niazi fullname: Niazi, Umar – sequence: 4 givenname: Grigorios surname: Tsaknakis fullname: Tsaknakis, Grigorios – sequence: 5 givenname: Giorgio L. surname: Papadopoulos fullname: Papadopoulos, Giorgio L. – sequence: 6 givenname: Riley orcidid: 0009-0001-5212-6057 surname: Cook fullname: Cook, Riley – sequence: 7 givenname: Mansoor surname: Saqi fullname: Saqi, Mansoor – sequence: 8 givenname: Jiannis orcidid: 0000-0002-8515-0934 surname: Ragoussis fullname: Ragoussis, Jiannis – sequence: 9 givenname: John orcidid: 0000-0002-6133-2872 surname: Strouboulis fullname: Strouboulis, John |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40048486$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kl1r2zAYhc3oWD-2fzA2wW66i2SSrS_vZoSyZIVCb7proUqvEgVHyiS70H8_pXFGU8rwhY38nKP3vJzz6iTEAFX1keApaQT5to5DCrqbbpcQpgQTwol4U50RxpqJoJiePPs-rc5zXmPcMNmKd9UpxZhKKvlZBTMU4gN0KMUOkIsJzZOHYFF0aDG7mxF0Ob9dTMhX5ANKsBw63fuwRGZV-NxDkaE-6ZC3MfU7ZjMkHwBBeuxXKW6jh-zz--qt012GD-P7ovo9_3l39Wtyc7u4vprdTAxraT9pORa8FVYQZ0gthSVWGg7cCWKEqO8tpYwyC45jCkxbqmvJG2dbDK0TnDQX1ee977aLWY0byqqpBWac8ZYV4npP2KjXapv8RqdHFbVXTwcxLZVOvTcdKM04UJC1dFpSw6zElBNrsOEcW05d8fox3jbcb8AaCGUT3ZHp8Z_gV2oZHxQhLWka3BSHy9EhxT9D2afa-Gyg63SAOJTBiaCybujT4F9eoK_HG6mlLgl8cLFcbHamaiZLayhtCC7U9BWqPBY23pSaOV_OjwSfnif9F_HQowJ83wMmxZwTOGV8X5oSd8F9pwhWu9IeZla70qqxtEVMX4gP_v-V_QXQw_Dn |
| CitedBy_id | crossref_primary_10_1126_science_adp4581 |
| Cites_doi | 10.1093/bioinformatics/btz931 10.1371/journal.pcbi.1007664 10.1038/nature05125 10.1128/MCB.22.9.3121-3128.2002 10.1074/jbc.M701228200 10.1016/j.molcel.2004.12.028 10.1182/blood.V94.1.87.413k41_87_96 10.1073/pnas.142302099 10.1084/jem.20070544 10.1016/S1097-2765(00)80312-3 10.1101/gad.177200 10.1007/978-981-15-6082-8_6 10.1073/pnas.0307612100 10.1101/gad.12.8.1176 10.1194/jlr.M500511-JLR200 10.1038/73480 10.1186/s12864-018-5362-x 10.1093/bioinformatics/btq466 10.1038/nmeth.4197 10.1128/MCB.00865-13 10.1016/j.molcel.2012.05.051 10.1089/omi.2011.0118 10.1101/gad.7.10.1871 10.1111/j.1365-2184.2011.00771.x 10.1182/blood-2004-04-1603 10.1074/jbc.M313987200 10.1242/dev.121.1.163 10.1074/jbc.M801794200 10.1016/S0092-8674(00)80318-9 10.1182/bloodadvances.2018024539 10.1016/j.molcel.2009.11.002 10.1242/dev.080440 10.1002/advs.202102669 10.1182/blood.V93.9.2867.409k24_2867_2875 10.1016/S0021-9258(19)69789-9 10.1038/sj.emboj.7600703 10.1073/pnas.0909296106 10.1016/j.bbadis.2010.12.024 10.1128/MCB.17.3.1642 10.1038/nprot.2013.143 10.1371/journal.pone.0106011 10.1515/hsz-2019-0244 10.1038/emboj.2009.336 10.1161/ATVBAHA.112.300134 10.1093/emboj/16.13.3965 10.1038/ng1180 10.1093/bioinformatics/btu170 10.1194/jlr.RA120000635 10.1038/sj.emboj.7600702 10.1016/j.molcel.2007.11.020 10.1016/0167-4889(86)90111-4 10.1182/blood-2007-08-104489 10.1093/emboj/19.11.2492 10.1074/jbc.M109.043497 10.3748/wjg.v10.i21.3081 10.1073/pnas.0506580102 10.1096/fj.202000941R 10.1074/jbc.M115.662668 10.1161/ATVBAHA.112.248971 10.1194/jlr.TR119000267 10.1016/S0021-9258(19)39976-4 10.1210/en.2005-1647 10.1038/349257a0 10.1038/s41580-019-0190-7 10.1073/pnas.0306315101 10.1002/jcp.1041100109 10.1128/MCB.23.14.5031-5042.2003 10.1016/j.stem.2012.04.024 10.1002/jss.400080404 |
| ContentType | Journal Article |
| Copyright | Copyright: © 2025 Roussis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. COPYRIGHT 2025 Public Library of Science 2025 Roussis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2025 Roussis et al 2025 Roussis et al 2025 Roussis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: Copyright: © 2025 Roussis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. – notice: COPYRIGHT 2025 Public Library of Science – notice: 2025 Roussis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2025 Roussis et al 2025 Roussis et al – notice: 2025 Roussis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QP 7QR 7SS 7TK 7TM 7TO 7X7 7XB 88E 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pgen.1011617 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Entomology Abstracts (Full archive) Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Journals Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student Oncogenes and Growth Factors Abstracts Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Genetics Abstracts Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection AIDS and Cancer Research Abstracts Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database CrossRef MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| DocumentTitleAlternate | FOG-1 and cholesterol transport in erythropoiesis |
| EISSN | 1553-7404 |
| ExternalDocumentID | 3270565695 oai_doaj_org_article_a56e4e828fa84c5d80461dc0c660d64f PMC11913303 A837144310 40048486 10_1371_journal_pgen_1011617 |
| Genre | Journal Article |
| GeographicLocations | United Kingdom |
| GeographicLocations_xml | – name: United Kingdom |
| GrantInformation_xml | – fundername: ; grantid: GA642934 |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7X7 88E 8FE 8FH 8FI 8FJ AAFWJ AAUCC AAWOE AAYXX ABDBF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV AEAQA AENEX AFFHD AFKRA AFPKN AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS B0M BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BHPHI BPHCQ BVXVI BWKFM CCPQU CITATION CS3 DIK DU5 E3Z EAP EAS EBD EBS EJD EMK EMOBN ESX F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HMCUK HYE IAO IGS IHR IHW INH INR IOV ISN ISR ITC KQ8 LK8 M1P M48 M7P O5R O5S OK1 OVT P2P PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PV9 QF4 QN7 RNS RPM RZL SV3 TR2 TUS UKHRP WOW XSB ~8M ADRAZ ALIPV C1A CGR CUY CVF ECM EIF H13 IPNFZ NPM RIG WOQ 3V. 7QP 7QR 7SS 7TK 7TM 7TO 7XB 8FD 8FK AZQEC DWQXO FR3 GNUQQ H94 K9. P64 PKEHL PQEST PQUKI PRINS RC3 7X8 5PM |
| ID | FETCH-LOGICAL-c594t-9607697d71fc1287d1d8c6e6f71c772bd44545def604e5ad4a2863fd90e9f7613 |
| IEDL.DBID | FPL |
| ISICitedReferencesCount | 1 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001443997200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1553-7404 1553-7390 |
| IngestDate | Tue Dec 02 00:10:36 EST 2025 Tue Oct 14 18:45:14 EDT 2025 Tue Nov 04 02:02:40 EST 2025 Sun Nov 09 09:18:23 EST 2025 Tue Nov 11 05:41:55 EST 2025 Tue Nov 11 10:49:03 EST 2025 Tue Nov 04 18:12:44 EST 2025 Mon Jul 21 05:21:15 EDT 2025 Sat Nov 29 08:05:21 EST 2025 Tue Nov 18 22:35:25 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Language | English |
| License | Copyright: © 2025 Roussis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c594t-9607697d71fc1287d1d8c6e6f71c772bd44545def604e5ad4a2863fd90e9f7613 |
| Notes | new_version ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 The authors have declared that no competing interests exist. |
| ORCID | 0000-0001-7176-8883 0009-0001-5212-6057 0000-0001-8747-7554 0000-0002-6133-2872 0000-0002-8515-0934 |
| OpenAccessLink | http://dx.doi.org/10.1371/journal.pgen.1011617 |
| PMID | 40048486 |
| PQID | 3270565695 |
| PQPubID | 1436339 |
| ParticipantIDs | plos_journals_3270565695 doaj_primary_oai_doaj_org_article_a56e4e828fa84c5d80461dc0c660d64f pubmedcentral_primary_oai_pubmedcentral_nih_gov_11913303 proquest_miscellaneous_3174823495 proquest_journals_3270565695 gale_infotracmisc_A837144310 gale_infotracacademiconefile_A837144310 pubmed_primary_40048486 crossref_citationtrail_10_1371_journal_pgen_1011617 crossref_primary_10_1371_journal_pgen_1011617 |
| PublicationCentury | 2000 |
| PublicationDate | 2025-03-01 |
| PublicationDateYYYYMMDD | 2025-03-01 |
| PublicationDate_xml | – month: 03 year: 2025 text: 2025-03-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PLoS genetics |
| PublicationTitleAlternate | PLoS Genet |
| PublicationYear | 2025 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | M Rylski (pgen.1011617.ref030) 2003; 23 H Jing (pgen.1011617.ref020) 2008; 29 PC Krishnamurthy (pgen.1011617.ref034) 2006; 443 RA Shivdasani (pgen.1011617.ref012) 1997; 16 J Luo (pgen.1011617.ref050) 2020; 21 KT Hung (pgen.1011617.ref058) 2012; 32 AB Cantor (pgen.1011617.ref046) 2008; 205 SX Ge (pgen.1011617.ref026) 2020; 36 M Weiss (pgen.1011617.ref044) 1997; 17 MI Love (pgen.1011617.ref070) 2020; 16 C Zhao (pgen.1011617.ref035) 2008; 283 P Rodriguez (pgen.1011617.ref074) 2006; 338 AR Tall (pgen.1011617.ref053) 2012; 32 JE Potter (pgen.1011617.ref054) 1981; 256 JD Crispino (pgen.1011617.ref013) 1999; 3 A Kucukural (pgen.1011617.ref071) 2019; 20 A Lachmann (pgen.1011617.ref027) 2010; 26 JA Hernandez (pgen.1011617.ref056) 2019; 3 W Hong (pgen.1011617.ref005) 2005; 24 MK Clifton (pgen.1011617.ref007) 2014; 9 KE Nichols (pgen.1011617.ref015) 2000; 24 P Vyas (pgen.1011617.ref011) 1999; 93 FA Ran (pgen.1011617.ref067) 2013; 8 D Sugiyama (pgen.1011617.ref047) 2008; 111 L Xu (pgen.1011617.ref031) 2020; 34 M Antoniou (pgen.1011617.ref065) 1991; 7 M Garriga-Canut (pgen.1011617.ref022) 2004; 279 RA Cooper (pgen.1011617.ref049) 1978; 8 A Miccio (pgen.1011617.ref021) 2010; 29 L-W Weber (pgen.1011617.ref040) 2004; 10 DJ Lavery (pgen.1011617.ref073) 1993; 7 TM Chlon (pgen.1011617.ref001) 2012; 139 VK Mootha (pgen.1011617.ref029) 2003; 34 AP Tsang (pgen.1011617.ref002) 1997; 90 Y Yamauchi (pgen.1011617.ref064) 2015; 290 L Pevny (pgen.1011617.ref010) 1991; 349 M Westerterp (pgen.1011617.ref052) 2012; 11 J Snow (pgen.1011617.ref008) 2009; 284 AM Bolger (pgen.1011617.ref068) 2014; 30 AN Chang (pgen.1011617.ref014) 2002; 99 S Pal (pgen.1011617.ref016) 2004; 101 R Patro (pgen.1011617.ref069) 2017; 14 TM Chlon (pgen.1011617.ref018) 2012; 47 L Pevny (pgen.1011617.ref009) 1995; 121 A Subramanian (pgen.1011617.ref028) 2005; 102 S Tshori (pgen.1011617.ref045) 2012 R Ohkawa (pgen.1011617.ref063) 2020; 61 C Mejia-Pous (pgen.1011617.ref062) 2011; 44 K Chen (pgen.1011617.ref023) 2009; 106 E Querfurth (pgen.1011617.ref048) 2000; 14 JR Smith (pgen.1011617.ref039) 1990; 265 J Liu (pgen.1011617.ref075) 2013; 121 A Tsiftsoglou (pgen.1011617.ref061) 1986; 889 G Yu (pgen.1011617.ref072) 2012; 16 JJ Welch (pgen.1011617.ref066) 2004; 104 N Wang (pgen.1011617.ref036) 2020 P Rodriguez (pgen.1011617.ref004) 2005; 24 PK Morgan (pgen.1011617.ref060) 2020; 61 Z Lu (pgen.1011617.ref041) 2022; 9 M Yamamoto (pgen.1011617.ref033) 2014; 34 SG Katz (pgen.1011617.ref006) 2002; 22 T Gregory (pgen.1011617.ref024) 1999; 94 DL Letting (pgen.1011617.ref017) 2004; 101 CR Vakoc (pgen.1011617.ref019) 2005; 17 DW Russell (pgen.1011617.ref051) 2009 S-J Lai (pgen.1011617.ref059) 2019; 400 OS Shirihai (pgen.1011617.ref032) 2000; 19 MJ Seo (pgen.1011617.ref025) 2012; 40 AP Tsang (pgen.1011617.ref003) 1998; 12 M Yu (pgen.1011617.ref037) 2009; 36 Y Yajima (pgen.1011617.ref042) 2006; 147 AM Quintana (pgen.1011617.ref055) 2014; 7 A Kosters (pgen.1011617.ref057) 2006; 47 N Tamehiro (pgen.1011617.ref038) 2007; 282 LS Rittmann (pgen.1011617.ref043) 1982; 110 |
| References_xml | – volume: 36 start-page: 2628 issue: 8 year: 2020 ident: pgen.1011617.ref026 article-title: ShinyGO: a graphical gene-set enrichment tool for animals and plants publication-title: Bioinformatics doi: 10.1093/bioinformatics/btz931 – volume: 16 start-page: e1007664 issue: 2 year: 2020 ident: pgen.1011617.ref070 article-title: Tximeta: Reference sequence checksums for provenance identification in RNA-seq publication-title: PLoS Comput Biol doi: 10.1371/journal.pcbi.1007664 – volume: 443 start-page: 586 issue: 7111 year: 2006 ident: pgen.1011617.ref034 article-title: Identification of a mammalian mitochondrial porphyrin transporter publication-title: Nature doi: 10.1038/nature05125 – volume: 22 start-page: 3121 issue: 9 year: 2002 ident: pgen.1011617.ref006 article-title: Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo publication-title: Mol Cell Biol doi: 10.1128/MCB.22.9.3121-3128.2002 – volume: 282 start-page: 21090 issue: 29 year: 2007 ident: pgen.1011617.ref038 article-title: Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status publication-title: J Biol Chem doi: 10.1074/jbc.M701228200 – volume: 17 start-page: 453 issue: 3 year: 2005 ident: pgen.1011617.ref019 article-title: Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1 publication-title: Mol Cell doi: 10.1016/j.molcel.2004.12.028 – volume: 94 start-page: 87 issue: 1 year: 1999 ident: pgen.1011617.ref024 article-title: GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression publication-title: Blood doi: 10.1182/blood.V94.1.87.413k41_87_96 – volume: 99 start-page: 9237 issue: 14 year: 2002 ident: pgen.1011617.ref014 article-title: GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.142302099 – volume: 205 start-page: 611 issue: 3 year: 2008 ident: pgen.1011617.ref046 article-title: Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage publication-title: J Exp Med doi: 10.1084/jem.20070544 – volume: 3 start-page: 219 issue: 2 year: 1999 ident: pgen.1011617.ref013 article-title: Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex publication-title: Mol Cell doi: 10.1016/S1097-2765(00)80312-3 – volume: 14 start-page: 2515 issue: 19 year: 2000 ident: pgen.1011617.ref048 article-title: Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors publication-title: Genes Dev doi: 10.1101/gad.177200 – start-page: 67 year: 2020 ident: pgen.1011617.ref036 article-title: ABC Transporters, Cholesterol Efflux, and Implications for Cardiovascular Diseases publication-title: Adv Exp Med Biol doi: 10.1007/978-981-15-6082-8_6 – volume: 101 start-page: 980 issue: 4 year: 2004 ident: pgen.1011617.ref016 article-title: Coregulator-dependent facilitation of chromatin occupancy by GATA-1 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0307612100 – volume: 12 start-page: 1176 issue: 8 year: 1998 ident: pgen.1011617.ref003 article-title: Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG publication-title: Genes Dev doi: 10.1101/gad.12.8.1176 – volume: 47 start-page: 1959 issue: 9 year: 2006 ident: pgen.1011617.ref057 article-title: The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice publication-title: J Lipid Res doi: 10.1194/jlr.M500511-JLR200 – volume: 24 start-page: 266 issue: 3 year: 2000 ident: pgen.1011617.ref015 article-title: Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1 publication-title: Nat Genet doi: 10.1038/73480 – volume: 121 start-page: e43-9 issue: 8 year: 2013 ident: pgen.1011617.ref075 article-title: Quantitative analysis of murine terminal erythroid differentiation in vivo: novel method to study normal and disordered erythropoiesis publication-title: Blood – volume: 20 start-page: 6 issue: 1 year: 2019 ident: pgen.1011617.ref071 article-title: DEBrowser: interactive differential expression analysis and visualization tool for count data publication-title: BMC Genomics doi: 10.1186/s12864-018-5362-x – volume: 26 start-page: 2438 issue: 19 year: 2010 ident: pgen.1011617.ref027 article-title: ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq466 – volume: 14 start-page: 417 issue: 4 year: 2017 ident: pgen.1011617.ref069 article-title: Salmon provides fast and bias-aware quantification of transcript expression publication-title: Nat Methods doi: 10.1038/nmeth.4197 – volume: 34 start-page: 1077 issue: 6 year: 2014 ident: pgen.1011617.ref033 article-title: Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation publication-title: Mol Cell Biol doi: 10.1128/MCB.00865-13 – volume: 47 start-page: 608 issue: 4 year: 2012 ident: pgen.1011617.ref018 article-title: Cofactor-mediated restriction of GATA-1 chromatin occupancy coordinates lineage-specific gene expression publication-title: Mol Cell doi: 10.1016/j.molcel.2012.05.051 – volume: 16 start-page: 284 issue: 5 year: 2012 ident: pgen.1011617.ref072 article-title: clusterProfiler: an R package for comparing biological themes among gene clusters publication-title: OMICS doi: 10.1089/omi.2011.0118 – volume: 7 start-page: 1871 issue: 10 year: 1993 ident: pgen.1011617.ref073 article-title: Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP publication-title: Genes Dev doi: 10.1101/gad.7.10.1871 – volume: 44 start-page: 441 issue: 5 year: 2011 ident: pgen.1011617.ref062 article-title: Cholesterol synthesis-related enzyme oxidosqualene cyclase is required to maintain self-renewal in primary erythroid progenitors publication-title: Cell Prolif doi: 10.1111/j.1365-2184.2011.00771.x – volume: 104 start-page: 3136 issue: 10 year: 2004 ident: pgen.1011617.ref066 article-title: Global regulation of erythroid gene expression by transcription factor GATA-1 publication-title: Blood doi: 10.1182/blood-2004-04-1603 – volume: 279 start-page: 23597 issue: 22 year: 2004 ident: pgen.1011617.ref022 article-title: Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis publication-title: J Biol Chem doi: 10.1074/jbc.M313987200 – volume: 121 start-page: 163 issue: 1 year: 1995 ident: pgen.1011617.ref009 article-title: Development of hematopoietic cells lacking transcription factor GATA-1 publication-title: Development doi: 10.1242/dev.121.1.163 – volume: 283 start-page: 17083 issue: 25 year: 2008 ident: pgen.1011617.ref035 article-title: Peptide specificity and lipid activation of the lysosomal transport complex ABCB9 (TAPL) publication-title: J Biol Chem doi: 10.1074/jbc.M801794200 – volume: 90 start-page: 109 issue: 1 year: 1997 ident: pgen.1011617.ref002 article-title: FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation publication-title: Cell doi: 10.1016/S0092-8674(00)80318-9 – volume: 3 start-page: 1244 issue: 8 year: 2019 ident: pgen.1011617.ref056 article-title: Mutations in the zebrafish hmgcs1 gene reveal a novel function for isoprenoids during red blood cell development publication-title: Blood Adv doi: 10.1182/bloodadvances.2018024539 – volume: 36 start-page: 682 issue: 4 year: 2009 ident: pgen.1011617.ref037 article-title: Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis publication-title: Mol Cell doi: 10.1016/j.molcel.2009.11.002 – volume: 139 start-page: 3905 issue: 21 year: 2012 ident: pgen.1011617.ref001 article-title: Combinatorial regulation of tissue specification by GATA and FOG factors publication-title: Development doi: 10.1242/dev.080440 – volume: 9 start-page: e2102669 issue: 2 year: 2022 ident: pgen.1011617.ref041 article-title: Fine-Tuning of Cholesterol Homeostasis Controls Erythroid Differentiation publication-title: Adv Sci (Weinh) doi: 10.1002/advs.202102669 – volume: 93 start-page: 2867 issue: 9 year: 1999 ident: pgen.1011617.ref011 article-title: Consequences of GATA-1 Deficiency in Megakaryocytes and Platelets publication-title: Blood doi: 10.1182/blood.V93.9.2867.409k24_2867_2875 – volume: 256 start-page: 2371 issue: 5 year: 1981 ident: pgen.1011617.ref054 article-title: Sequential cycles of cholesterol and dolichol synthesis in mouse spleens during phenylhydrazine-induced erythropoiesis publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)69789-9 – volume: 24 start-page: 2367 issue: 13 year: 2005 ident: pgen.1011617.ref005 article-title: FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1 publication-title: EMBO J doi: 10.1038/sj.emboj.7600703 – volume: 106 start-page: 17413 issue: 41 year: 2009 ident: pgen.1011617.ref023 article-title: Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0909296106 – start-page: 42 issue: 1 year: 2012 ident: pgen.1011617.ref045 article-title: Mast cell transcription factors--regulators of cell fate and phenotype publication-title: Biochim Biophys Acta doi: 10.1016/j.bbadis.2010.12.024 – volume: 17 start-page: 1642 issue: 3 year: 1997 ident: pgen.1011617.ref044 article-title: Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line publication-title: Mol Cell Biol doi: 10.1128/MCB.17.3.1642 – volume: 8 start-page: 2281 issue: 11 year: 2013 ident: pgen.1011617.ref067 article-title: Genome engineering using the CRISPR-Cas9 system publication-title: Nat Protoc doi: 10.1038/nprot.2013.143 – volume: 9 start-page: e106011 issue: 8 year: 2014 ident: pgen.1011617.ref007 article-title: The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins publication-title: PLoS One doi: 10.1371/journal.pone.0106011 – volume: 400 start-page: 1593 issue: 12 year: 2019 ident: pgen.1011617.ref059 article-title: Red blood cells participate in reverse cholesterol transport by mediating cholesterol efflux of high-density lipoprotein and apolipoprotein A-I from THP-1 macrophages publication-title: Biol Chem doi: 10.1515/hsz-2019-0244 – volume: 29 start-page: 442 issue: 2 year: 2010 ident: pgen.1011617.ref021 article-title: NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development publication-title: EMBO J doi: 10.1038/emboj.2009.336 – volume: 32 start-page: 2547 issue: 11 year: 2012 ident: pgen.1011617.ref053 article-title: Cholesterol efflux: a novel regulator of myelopoiesis and atherogenesis publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.112.300134 – volume: 16 start-page: 3965 issue: 13 year: 1997 ident: pgen.1011617.ref012 article-title: A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development publication-title: EMBO J doi: 10.1093/emboj/16.13.3965 – volume: 7 start-page: 265 issue: 2 year: 2014 ident: pgen.1011617.ref055 article-title: Zebrafish ETV7 regulates red blood cell development through the cholesterol synthesis pathway publication-title: Dis Models Mech – volume: 34 start-page: 267 issue: 3 year: 2003 ident: pgen.1011617.ref029 article-title: PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes publication-title: Nat Genet doi: 10.1038/ng1180 – volume: 30 start-page: 2114 issue: 15 year: 2014 ident: pgen.1011617.ref068 article-title: Trimmomatic: a flexible trimmer for Illumina sequence data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu170 – volume: 61 start-page: 1577 issue: 12 year: 2020 ident: pgen.1011617.ref063 article-title: Cholesterol transport between red blood cells and lipoproteins contributes to cholesterol metabolism in blood publication-title: J Lipid Res doi: 10.1194/jlr.RA120000635 – volume: 24 start-page: 2354 issue: 13 year: 2005 ident: pgen.1011617.ref004 article-title: GATA-1 forms distinct activating and repressive complexes in erythroid cells publication-title: EMBO J doi: 10.1038/sj.emboj.7600702 – volume: 29 start-page: 232 issue: 2 year: 2008 ident: pgen.1011617.ref020 article-title: Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus publication-title: Mol Cell doi: 10.1016/j.molcel.2007.11.020 – volume: 889 start-page: 251 issue: 2 year: 1986 ident: pgen.1011617.ref061 article-title: The inhibition of commitment of mouse erythroleukemia cells by steroids involves a glucocorticoid-receptor mediated process(es) acting at the nuclear level publication-title: Biochim Biophys Acta doi: 10.1016/0167-4889(86)90111-4 – volume: 111 start-page: 1924 issue: 4 year: 2008 ident: pgen.1011617.ref047 article-title: Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation publication-title: Blood doi: 10.1182/blood-2007-08-104489 – volume: 7 start-page: 421 year: 1991 ident: pgen.1011617.ref065 article-title: Induction of Erythroid-Specific Expression in Murine Erythroleukemia (MEL) Cell Lines publication-title: Methods Mol Biol – volume: 19 start-page: 2492 issue: 11 year: 2000 ident: pgen.1011617.ref032 article-title: ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation publication-title: EMBO J doi: 10.1093/emboj/19.11.2492 – volume: 284 start-page: 29310 issue: 43 year: 2009 ident: pgen.1011617.ref008 article-title: Translational isoforms of FOG1 regulate GATA1-interacting complexes publication-title: J Biol Chem doi: 10.1074/jbc.M109.043497 – volume: 10 start-page: 3081 issue: 21 year: 2004 ident: pgen.1011617.ref040 article-title: Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins publication-title: World J Gastroenterol doi: 10.3748/wjg.v10.i21.3081 – volume: 102 start-page: 15545 issue: 43 year: 2005 ident: pgen.1011617.ref028 article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0506580102 – volume: 34 start-page: 13194 issue: 10 year: 2020 ident: pgen.1011617.ref031 article-title: miR-144/451 inhibits c-Myc to promote erythroid differentiation publication-title: FASEB Journal doi: 10.1096/fj.202000941R – start-page: S120-5 issue: Suppl year: 2009 ident: pgen.1011617.ref051 article-title: Fifty years of advances in bile acid synthesis and metabolism publication-title: J Lipid Res – volume: 290 start-page: 23464 issue: 39 year: 2015 ident: pgen.1011617.ref064 article-title: Deficiency in the lipid exporter ABCA1 impairs retrograde sterol movement and disrupts sterol sensing at the endoplasmic reticulum publication-title: J Biol Chem doi: 10.1074/jbc.M115.662668 – volume: 32 start-page: 1460 issue: 6 year: 2012 ident: pgen.1011617.ref058 article-title: Red blood cells play a role in reverse cholesterol transport publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.112.248971 – volume: 61 start-page: 667 issue: 5 year: 2020 ident: pgen.1011617.ref060 article-title: Hematopoiesis is regulated by cholesterol efflux pathways and lipid rafts: connections with cardiovascular diseases publication-title: J Lipid Res doi: 10.1194/jlr.TR119000267 – volume: 265 start-page: 2306 issue: 4 year: 1990 ident: pgen.1011617.ref039 article-title: Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)39976-4 – volume: 147 start-page: 4811 issue: 10 year: 2006 ident: pgen.1011617.ref042 article-title: Calpain system regulates the differentiation of adult primitive mesenchymal ST-13 adipocytes publication-title: Endocrinology doi: 10.1210/en.2005-1647 – volume: 40 start-page: 655 issue: 3 year: 2012 ident: pgen.1011617.ref025 article-title: GATA-binding protein 1 is a novel transcription regulator of peroxiredoxin 5 in human breast cancer cells publication-title: Int J Oncol – volume: 349 start-page: 257 issue: 6306 year: 1991 ident: pgen.1011617.ref010 article-title: Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1 publication-title: Nature doi: 10.1038/349257a0 – volume: 21 start-page: 225 issue: 4 year: 2020 ident: pgen.1011617.ref050 article-title: Mechanisms and regulation of cholesterol homeostasis publication-title: Nat Rev Mol Cell Biol doi: 10.1038/s41580-019-0190-7 – volume: 338 start-page: 305 year: 2006 ident: pgen.1011617.ref074 article-title: Isolation of transcription factor complexes by in vivo biotinylation tagging and direct binding to streptavidin beads publication-title: Methods Mol Biol – volume: 101 start-page: 476 issue: 2 year: 2004 ident: pgen.1011617.ref017 article-title: Context-dependent regulation of GATA-1 by friend of GATA-1 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0306315101 – volume: 110 start-page: 50 issue: 1 year: 1982 ident: pgen.1011617.ref043 article-title: Lipid composition of Friend leukemia cells following induction of erythroid differentiation by dimethyl sulfoxide publication-title: J Cell Physiol doi: 10.1002/jcp.1041100109 – volume: 23 start-page: 5031 issue: 14 year: 2003 ident: pgen.1011617.ref030 article-title: GATA-1-mediated proliferation arrest during erythroid maturation publication-title: Mol Cell Biol doi: 10.1128/MCB.23.14.5031-5042.2003 – volume: 11 start-page: 195 issue: 2 year: 2012 ident: pgen.1011617.ref052 article-title: Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways publication-title: Cell Stem Cell doi: 10.1016/j.stem.2012.04.024 – volume: 8 start-page: 413 issue: 4 year: 1978 ident: pgen.1011617.ref049 article-title: Influence of increased membrane cholesterol on membrane fluidity and cell function in human red blood cells publication-title: J Supramol Struct doi: 10.1002/jss.400080404 |
| SSID | ssj0035897 |
| Score | 2.4723387 |
| Snippet | Friend of GATA1 (FOG-1) is an essential transcriptional co-factor of the master erythroid transcription factor GATA1. The knockout of the Zfpm1 gene, coding... |
| SourceID | plos doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e1011617 |
| SubjectTerms | ABCA1 protein Anemia Animals ATP Binding Cassette Transporter 1 - genetics ATP Binding Cassette Transporter 1 - metabolism ATP-binding protein Biological transport Biological Transport - genetics Biology and Life Sciences Cell cycle Cell differentiation Cell Differentiation - genetics Cholesterol Cholesterol - metabolism Cloning CRISPR CRISPR-Cas Systems Embryos Erythropoiesis Erythropoiesis - genetics Flow cytometry Fluidity GATA-1 protein GATA1 Transcription Factor - genetics GATA1 Transcription Factor - metabolism Gene expression Gene regulation Gene silencing Genetic aspects Genotype & phenotype Homeostasis Lethality Membrane fluidity Mice Mice, Knockout Phenotypes Physiological aspects Proteins Research and Analysis Methods Sterol Regulatory Element Binding Protein 2 - genetics Sterol Regulatory Element Binding Protein 2 - metabolism Transcription Factors - genetics Transcription Factors - metabolism |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Na9wwEBVlSaGX0u9smxQVCm0PamxLluSjE7rpKe0hhdyMVxrRha297G4C-fedsWwTl0AuvVpjY82MRm_s0RvGProCpNa5Ez5ZglAyA1Eb-tq0XBrjfUYnf7pmE-biwl5dFT_vtPqimrBIDxwVd1LnGhRgXhBqq1zuLTGEe5c4rROvVaDoi6hnSKZiDJa5jW1V8lwKg2l9f2hOmvSkt9HXDRqIclcC-JNNqePuHyP0bLNud_fBz3-rKO9sS4tn7GmPJ3kZ5_GcPYLmBXscO0zevmRQ8qa9gTWnKkKOAJUviNjY8zbw8_KyTPnnxY9zkX7hq4ZvY1963Mw4BcWOQ6Fd8_3Af04yf-jrPHDY3sYGC5hor3av2K_Ft8uz76LvrCBcXqi9wLTF6MJ4kwaHG5TxqbdOgw4mdQi3l14pRFYegk4U5LVXdWa1DL5IoAgGEcBrNmvaBg4Zl7jgM11ntQlSWfDoEyYkjg7UysyCnjM5qLZyPe04db9YV92_NIPpR9RURQapeoPMmRjv2kTajQfkT8lqoyyRZncX0JWq3pWqh1xpzj6RzSta2viKru5PKOBEiSSrKi3RGyLiSubsaCKJS9JNhg_Ja4Y33VUyMwkh5yLHOwdPun_4wzhMD6UKuAbaa5TB1NFmUpHMm-h442y7OKws6tpOXHKijulIs_rdcYkTv59EGPP2fyjwHXuSUXvkrkTviM3222s4ZgfuZr_abd93K_Qvjyo-xw priority: 102 providerName: Directory of Open Access Journals – databaseName: Biological Science Database dbid: M7P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZgAYkLb-hCQUZCAg6mSezYzgkFxJZT6aFIvUVZP8pKS7JstpX675lxnEBQBQeu8SSyPePxN874G0JemcJxKXPDbLJ0TPDMsVrhadNyqZS1Gd78CcUm1NGRPj0tjuOBWxfTKgefGBy1bQ2ekR_wTCUIPor8_eYHw6pR-Hc1ltC4Tm4gSwIPqXvHgyfmue6Lq-Q5ZwqC-3h1jqv0IGrq3QbUhBEswvzJ1hQY_Ec_Pdus2-4qEPpnLuVvm9Pi7v8O6x65E2EpLXs7uk-uueYBudUXqrx8SFxJm_bCrSkmI1LAuXSB_MiWtp4elidlSt8svhyy9C1dNXTbl7eHPZGibw1UDO2a7gYadZT5jof8jrrtZV-nAeL1VfeIfF18Ovn4mcUCDczkhdgxiH6ULJRVqTewzymbWm2kk16lBlD70goBAM06LxPh8tqKOtOSe1skrvAKgMRjMmvaxu0RysFvZLLOauW50M6CaSmfGLyXyzPt5JzwQTeViezlWERjXYVfcgqimH6mKtRoFTU6J2x8a9Ozd_xD_gOqfZRF7u3woN2eVXEpV3UunXAQqfpaC5NbjZz11iRGysRK4efkNRpNhR4CumjqeNEBBopcW1WpkSURgFsyJ_sTSVjZZtK8h2Y39LSrfhkLvDmY09XNL8dm_Cgm0jWuPQcZiEB1xgXKPOktdxxtcOdCw1zriU1PpmPa0qy-BUpypAnkgIae_r1fz8jtDOsnhxy-fTLbbc_dc3LTXOxW3fZFWLw_AdA2TM4 priority: 102 providerName: ProQuest |
| Title | A novel role for Friend of GATA1 (FOG-1) in regulating cholesterol transport in murine erythropoiesis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/40048486 https://www.proquest.com/docview/3270565695 https://www.proquest.com/docview/3174823495 https://pubmed.ncbi.nlm.nih.gov/PMC11913303 https://doaj.org/article/a56e4e828fa84c5d80461dc0c660d64f http://dx.doi.org/10.1371/journal.pgen.1011617 |
| Volume | 21 |
| WOSCitedRecordID | wos001443997200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: DOA dateStart: 20050101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: M7P dateStart: 20050701 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: 7X7 dateStart: 20050701 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: BENPR dateStart: 20050701 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: PIMPY dateStart: 20050701 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: FPL dateStart: 20050701 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELdYBxIvfMMKIzISEvCQkcSO7TxmaBlIUCI0pPIUpbYjKpWkartJ---5cz4g0ybESx_qc-ucz-ffOeffEfJaJ5YJEWvfBAvrcxZZv5R42rRYSGlMhDd_XLEJOZup-TzJ_wSKV97gMxm-73R6tAaFYqyJgHyP7EfwF5jCleWfe8_LYpXI7nrcTT1H249j6R988WS9arbXAc2r-ZJ_bUDZ_f8d-gNyr4OaNG1t4yG5ZetH5E5bfPLyMbEprZsLu6KYYEgBu9IMOY8NbSp6mp6lIX2bfT31w3d0WdNNW7Ie9jmK_tLRKzQruuup0VHmFx7cW2o3l23tBYjBl9sn5Ht2cvbho98VXfB1nPCdDxGNFIk0Mqw07F3ShEZpYUUlQw1IfGE4B9BlbCUCbuPS8DJSglUmCWxSSQAHT8mkbmp7QCgDXxCJMiplxbiyBsxFVoHGu7YsUlZMCevnotAdIzkWxlgV7jWbhMik1VSBCiw6BU6JP_Rat4wc_5A_xmkeZJFP230BM1V0y7MoY2G5heizKhXXsVHIQ290oIUIjODVlLxBIylw1cMQddldXoAHRf6sIlXIfAhgLJiSw5EkrFY9aj5AM-tHui1YJAME1UkMPXvTu7751dCMP4rJcbVtzkEGokoVMY4yz1pLHZ7WuWiuQNdqZMMjdYxb6uVPRzOO1H8MEM7zm4f8gtyNsB6yy8k7JJPd5ty-JLf1xW653XhkT86l-1Qe2T8-meXfPHfm4bll62GebQ4t-acv-Y_fBstAHA |
| linkProvider | Public Library of Science |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLZGB4IX7rDCACOBgIewxHZs5wGhculWbSt7KNJ4CqntlEolKU031D_Fb-ScXApBEzztgdf6JLLdz8fnxD7fR8gTEzkuZWg864-dJzhzXqLwa9N4rJS1DCt_SrEJNRzq4-PoaIP8aGph8Fpl4xNLR21zg9_IdzhTPgYfUfh6_s1D1Sg8XW0kNCpY7LvVd0jZileDd_D_PmWs_370ds-rVQU8E0Zi6UHIrmSkrApSA85Z2cBqI51MVWAg1BxbISCqsC6VvnBhYkXCtOSpjXwXpZD0c3jvBbIpAOy6QzaPBodHnxrfz0NdybmEIfcUj_y6WI-rYKfGxss5AANzZkwsWpthqRmw3hk681lenBX2_nl787ftsH_tf5vI6-RqHXjTXrVSbpANl90klyopztUt4no0y0_djOJ1SwqRPO0jA7SleUp3e6NeQJ_3P-x6wQs6zejCTUrVs2xCcfcoySbyGV02RPFo8xWPMRx1i1WlRDF1xbS4TT6eyxjvkE6WZ26LUA6ekcmEJSrlQjsLi0elvsHKY860k13CGyzEpuZnR5mQWVweOirI06qZihFBcY2gLvHWT80rfpJ_2L9BmK1tkV28_CFfTOLaWcVJKJ1wkIuniRYmtBpZ-a3xjZS-lSLtkmcI0hh9IHTRJHUpBwwU2cTinkYeSAhN_S7ZblmC7zKt5i2EedPTIv4FTniyge_ZzY_XzfhSvCqYufwEbCDH1owLtLlbrZT1aMsNS2iYa91aQ63paLdk0y8l6ToSIXKI9-79vV-PyOW90eFBfDAY7t8nVxiqRZc3FrdJZ7k4cQ_IRXO6nBaLh7XroOTzeS-yn-Khqk0 |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3Nb9MwFLdG-RAXvmGFAUYCAYfQJHZs54BQYXRMQ6WHTdotpLZTKpWkJN1Q_zX-Ot5zkkLQBKcduNYvke2-z_j59yPkqY4tEyLSnvGn1uMstF4q8WvTdCqlMSHe_HFkE3I8VsfH8WSL_GjvwmBbZesTnaM2hcZv5AMWSh-TjzgaZE1bxGR39Gb5zUMGKTxpbek0ahU5sOvvUL5Vr_d34b9-Foaj94fvPngNw4Cno5ivPEjfpYilkUGmwVFLExilhRWZDDSknVPDOWQYxmbC5zZKDU9DJVhmYt_GmYRICO-9QC5KBC13bYOTNgqwSNXELlHEPMliv7m2x2QwaLTk1RJUBKtnLDE6YdGxB2xiRG-5KKqzEuA_-zh_C4yj6__zlt4g15p0nA5r-7lJtmx-i1yuCTrXt4kd0rw4tQuKTZgU8ns6QlxoQ4uM7g0PhwF9Mfq05wUv6TynpZ05LrR8RjGmOAiKYkFXLXw8ynzFww1Lbbmu-SnmtppXd8jRuazxLunlRW63CWXgL0ORhqnMGFfWgEnJzNd4H5mFyoo-Ya1eJLpBbUfykEXijiIlVG_1TiWoTUmjTX3ibZ5a1qgl_5B_iyq3kUXMcfdDUc6SxoUlaSQst1ChZ6niOjIKsfqN9rUQvhE865PnqLAJekaYok6bCx6wUMQYS4YK0SEhYfX7ZKcjCR5Nd4a3UeXbmVbJL0WFJ1tVPnv4yWYYX4oNhLktTkAGKm8VMo4y92qr2azWhTGuYK9Vx54629EdyedfHBQ7wiMyyALv_31ej8kVsKzk4_744AG5GiKFtGtj3CG9VXliH5JL-nQ1r8pHzodQ8vm8LewnUoCxjA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+novel+role+for+Friend+of+GATA1+%28FOG-1%29+in+regulating+cholesterol+transport+in+murine+erythropoiesis&rft.jtitle=PLoS+genetics&rft.au=Roussis%2C+Ioannis-Marios&rft.au=Pearton%2C+David+J&rft.au=Niazi%2C+Umar&rft.au=Tsaknakis%2C+Grigorios&rft.date=2025-03-01&rft.issn=1553-7404&rft.eissn=1553-7404&rft.volume=21&rft.issue=3&rft.spage=e1011617&rft_id=info:doi/10.1371%2Fjournal.pgen.1011617&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1553-7404&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1553-7404&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1553-7404&client=summon |