Protective immunity against COVID-19: Unravelling the evidences for humoral vs. cellular components

Once severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the host via contact, droplet or aerosol-mediated transmission [1], the non-specific innate immune response is followed by antigen-specific adaptive immunity mediated by B cells (humoral immunity) producing neutralizing antibod...

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Bibliographic Details
Published in:Travel medicine and infectious disease Vol. 39; p. 101911
Main Authors: Priyanka, Choudhary, Om Prakash, Singh, Indraj
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 01.01.2021
Elsevier Limited
Subjects:
Adaptive Immunity
Animal models
Antibodies
Antigens
Asymptomatic
B cell
Cells
Cold
Coronaviruses
Correspondence
COVID-19
COVID-19 - immunology
COVID-19 - prevention & control
COVID-19 Vaccines - immunology
Defence mechanisms
Disease transmission
Editing
Herd immunity
Humans
Immune response
Immunity
Immunology
Infections
Infectious Disease
Infectious diseases
Lymphocytes
Memory
Middle East respiratory syndrome
Mitigation
Reinfection - immunology
SARS-CoV-2
SARS-CoV-2 - immunology
Severe acute respiratory syndrome coronavirus 2
T cell
Travel medicine
Vaccines
Writing
COVID-19
B cell
SARS-CoV-2
Immunity
T cell
Memory
ISSN:1477-8939, 1873-0442, 1873-0442
Online Access:Get full text
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Summary:Once severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the host via contact, droplet or aerosol-mediated transmission [1], the non-specific innate immune response is followed by antigen-specific adaptive immunity mediated by B cells (humoral immunity) producing neutralizing antibodies and T cells (cellular immunity) including CD8+, CD4+ and regulatory T cells. In an outbreak with 85% attack rate, the neutralizing antibodies from previous SARS-CoV-2 infection were significantly associated with protection against re-infection (also observed in animal models like rhesus macaques) [3]. The present-day caveat is waiving off of immunity passports and compliance of mitigation measures by recovered patients as diligently as the unexposed population at risk.Ethical approval This article does not require any human/animal subjects to acquire such approval.Funding There is no funding source used for this paper.CRediT authorship contribution statement Priyanka: Conceptualization, Data curation, Visualization, Writing - original draft, Writing - review & editing.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
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ISSN:1477-8939
1873-0442
1873-0442
DOI:10.1016/j.tmaid.2020.101911