Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies

Anticancer therapies, such as targeting of STAT3 or the use of anthracyclins (doxorubicin), can induce cardiomyopathy. In mice prone to developing heart failure as a result of reduced cardiac STAT3 expression (cardiomyocyte-restricted deficiency of STAT3) or treatment with doxorubicin, we observed i...

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Veröffentlicht in:	Cell stem cell Jg. 9; H. 2; S. 131
Hauptverfasser:	Hoch, Melanie, Fischer, Philipp, Stapel, Britta, Missol-Kolka, Ewa, Sekkali, Belaid, Scherr, Michaela, Favret, Fabrice, Braun, Thomas, Eder, Matthias, Schuster-Gossler, Karin, Gossler, Achim, Hilfiker, Andres, Balligand, Jean-Luc, Drexler, Helmut, Hilfiker-Kleiner, Denise
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 05.08.2011
Schlagworte:	Adipocytes - cytology Adipocytes - drug effects Animals Antigens, Ly - metabolism Antineoplastic Agents - adverse effects Capillaries - drug effects Capillaries - pathology Cell Differentiation - drug effects Doxorubicin - pharmacology Doxorubicin - therapeutic use Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Erythropoietin - pharmacology Erythropoietin - therapeutic use Fibroblasts - cytology Fibroblasts - drug effects Gene Deletion Heart Failure - chemically induced Heart Failure - drug therapy Heart Failure - physiopathology Heart Function Tests - drug effects Humans Membrane Proteins - metabolism Mice Mice, Knockout Myocardium - pathology Organ Specificity - drug effects Pericytes - cytology Pericytes - drug effects Receptors, CCR2 - metabolism Receptors, Erythropoietin - metabolism STAT3 Transcription Factor - metabolism Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism Survival Analysis Vascular Endothelial Growth Factor Receptor-2 - metabolism
ISSN:	1875-9777, 1875-9777
Online-Zugang:	Weitere Angaben
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