Genetics in Parkinson disease: Mendelian versus non‐Mendelian inheritance
Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with resting tremor, postural instability, rigidity, bradykinesia, and a good response to levodopa therapy. Over the...
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| Vydáno v: | Journal of neurochemistry Ročník 139; číslo S1; s. 59 - 74 |
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| Hlavní autoři: | , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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England
Blackwell Publishing Ltd
01.10.2016
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| ISSN: | 0022-3042, 1471-4159, 1471-4159 |
| On-line přístup: | Získat plný text |
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| Abstract | Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with resting tremor, postural instability, rigidity, bradykinesia, and a good response to levodopa therapy. Over the last 15 years, numerous studies have confirmed that genetic factors contribute to the complex pathogenesis of PD. Highly penetrant mutations producing rare, monogenic forms of the disease have been discovered in singular genes such as SNCA, Parkin, DJ‐1, PINK 1, LRRK2, and VPS35. Unique variants with incomplete penetrance in LRRK2 and GBA have been shown to be strong risk factors for PD in certain populations. Additionally, over 20 common variants with small effect sizes are now recognized to modulate the risk for PD. Investigating Mendelian forms of PD has provided precious insight into the pathophysiology that underlies the more common idiopathic form of disease; however, no treatment methodologies have developed. Furthermore, for identified common risk alleles, the functional basis underlying risk principally remains unknown. The challenge over the next decade will be to strengthen the findings delivered through genetic discovery by assessing the direct, biological consequences of risk variants in tandem with additional high‐content, integrated datasets.
This review discusses monogenic risk factors and mechanisms of Mendelian inheritance of Parkinson disease. Highly penetrant mutations in SNCA, Parkin, DJ‐1, PINK 1, LRRK2 and VPS35 produce rare, monogenic forms of the disease, while unique variants within LRRK2 and GBA show incomplete penetrance and are strong risk factors for PD. Additionally, over 20 common variants with small effect sizes modulate disease risk. The challenge over the next decade is to strengthen genetic findings by assessing direct, biological consequences of risk variants in tandem with high‐content, integrated datasets.
This article is part of a special issue on Parkinson disease.
This review discusses monogenic risk factors and mechanisms of Mendelian inheritance of Parkinson disease. Highly penetrant mutations in SNCA, Parkin, DJ‐1, PINK 1, LRRK2 and VPS35 produce rare, monogenic forms of the disease, while unique variants within LRRK2 and GBA show incomplete penetrance and are strong risk factors for PD. Additionally, over 20 common variants with small effect sizes modulate disease risk. The challenge over the next decade is to strengthen genetic findings by assessing direct, biological consequences of risk variants in tandem with high‐content, integrated datasets.
This article is part of a special issue on Parkinson disease. |
|---|---|
| AbstractList | Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with resting tremor, postural instability, rigidity, bradykinesia, and a good response to levodopa therapy. Over the last 15 years, numerous studies have confirmed that genetic factors contribute to the complex pathogenesis of PD. Highly penetrant mutations producing rare, monogenic forms of the disease have been discovered in singular genes such as SNCA, Parkin, DJ-1, PINK 1, LRRK2, and VPS35. Unique variants with incomplete penetrance in LRRK2 and GBA have been shown to be strong risk factors for PD in certain populations. Additionally, over 20 common variants with small effect sizes are now recognized to modulate the risk for PD. Investigating Mendelian forms of PD has provided precious insight into the pathophysiology that underlies the more common idiopathic form of disease; however, no treatment methodologies have developed. Furthermore, for identified common risk alleles, the functional basis underlying risk principally remains unknown. The challenge over the next decade will be to strengthen the findings delivered through genetic discovery by assessing the direct, biological consequences of risk variants in tandem with additional high-content, integrated datasets. This review discusses monogenic risk factors and mechanisms of Mendelian inheritance of Parkinson disease. Highly penetrant mutations in SNCA, Parkin, DJ-1, PINK 1, LRRK2 and VPS35 produce rare, monogenic forms of the disease, while unique variants within LRRK2 and GBA show incomplete penetrance and are strong risk factors for PD. Additionally, over 20 common variants with small effect sizes modulate disease risk. The challenge over the next decade is to strengthen genetic findings by assessing direct, biological consequences of risk variants in tandem with high-content, integrated datasets. This article is part of a special issue on Parkinson disease. Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with resting tremor, postural instability, rigidity, bradykinesia, and a good response to levodopa therapy. Over the last 15 years, numerous studies have confirmed that genetic factors contribute to the complex pathogenesis of PD. Highly penetrant mutations producing rare, monogenic forms of the disease have been discovered in singular genes such as SNCA, Parkin, DJ-1, PINK 1, LRRK2,and VPS35. Unique variants with incomplete penetrance in LRRK2 and GBA have been shown to be strong risk factors for PD in certain populations. Additionally, over 20 common variants with small effect sizes are now recognized to modulate the risk for PD. Investigating Mendelian forms of PD has provided precious insight into the pathophysiology that underlies the more common idiopathic form of disease; however, no treatment methodologies have developed. Furthermore, for identified common risk alleles, the functional basis underlying risk principally remains unknown. The challenge over the next decade will be to strengthen the findings delivered through genetic discovery by assessing the direct, biological consequences of risk variants in tandem with additional high-content, integrated datasets. This review discusses monogenic risk factors and mechanisms of Mendelian inheritance of Parkinson disease. Highly penetrant mutations in SNCA, Parkin, DJ-1, PINK 1, LRRK2 and VPS35 produce rare, monogenic forms of the disease, while unique variants within LRRK2 and GBA show incomplete penetrance and are strong risk factors for PD. Additionally, over 20 common variants with small effect sizes modulate disease risk. The challenge over the next decade is to strengthen genetic findings by assessing direct, biological consequences of risk variants in tandem with high-content, integrated datasets. This article is part of aspecial issue on Parkinson disease. Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with resting tremor, postural instability, rigidity, bradykinesia, and a good response to levodopa therapy. Over the last 15 years, numerous studies have confirmed that genetic factors contribute to the complex pathogenesis of PD. Highly penetrant mutations producing rare, monogenic forms of the disease have been discovered in singular genes such as SNCA, Parkin, DJ‐1, PINK 1, LRRK2, and VPS35. Unique variants with incomplete penetrance in LRRK2 and GBA have been shown to be strong risk factors for PD in certain populations. Additionally, over 20 common variants with small effect sizes are now recognized to modulate the risk for PD. Investigating Mendelian forms of PD has provided precious insight into the pathophysiology that underlies the more common idiopathic form of disease; however, no treatment methodologies have developed. Furthermore, for identified common risk alleles, the functional basis underlying risk principally remains unknown. The challenge over the next decade will be to strengthen the findings delivered through genetic discovery by assessing the direct, biological consequences of risk variants in tandem with additional high‐content, integrated datasets. This review discusses monogenic risk factors and mechanisms of Mendelian inheritance of Parkinson disease. Highly penetrant mutations in SNCA, Parkin, DJ‐1, PINK 1, LRRK2 and VPS35 produce rare, monogenic forms of the disease, while unique variants within LRRK2 and GBA show incomplete penetrance and are strong risk factors for PD. Additionally, over 20 common variants with small effect sizes modulate disease risk. The challenge over the next decade is to strengthen genetic findings by assessing direct, biological consequences of risk variants in tandem with high‐content, integrated datasets. This article is part of a special issue on Parkinson disease. This review discusses monogenic risk factors and mechanisms of Mendelian inheritance of Parkinson disease. Highly penetrant mutations in SNCA, Parkin, DJ‐1, PINK 1, LRRK2 and VPS35 produce rare, monogenic forms of the disease, while unique variants within LRRK2 and GBA show incomplete penetrance and are strong risk factors for PD. Additionally, over 20 common variants with small effect sizes modulate disease risk. The challenge over the next decade is to strengthen genetic findings by assessing direct, biological consequences of risk variants in tandem with high‐content, integrated datasets. This article is part of a special issue on Parkinson disease. Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with resting tremor, postural instability, rigidity, bradykinesia, and a good response to levodopa therapy. Over the last 15 years, numerous studies have confirmed that genetic factors contribute to the complex pathogenesis of PD. Highly penetrant mutations producing rare, monogenic forms of the disease have been discovered in singular genes such as SNCA, Parkin, DJ-1, PINK 1, LRRK2, and VPS35. Unique variants with incomplete penetrance in LRRK2 and GBA have been shown to be strong risk factors for PD in certain populations. Additionally, over 20 common variants with small effect sizes are now recognized to modulate the risk for PD. Investigating Mendelian forms of PD has provided precious insight into the pathophysiology that underlies the more common idiopathic form of disease; however, no treatment methodologies have developed. Furthermore, for identified common risk alleles, the functional basis underlying risk principally remains unknown. The challenge over the next decade will be to strengthen the findings delivered through genetic discovery by assessing the direct, biological consequences of risk variants in tandem with additional high-content, integrated datasets. This review discusses monogenic risk factors and mechanisms of Mendelian inheritance of Parkinson disease. Highly penetrant mutations in SNCA, Parkin, DJ-1, PINK 1, LRRK2 and VPS35 produce rare, monogenic forms of the disease, while unique variants within LRRK2 and GBA show incomplete penetrance and are strong risk factors for PD. Additionally, over 20 common variants with small effect sizes modulate disease risk. The challenge over the next decade is to strengthen genetic findings by assessing direct, biological consequences of risk variants in tandem with high-content, integrated datasets. This article is part of a special issue on Parkinson disease.Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with resting tremor, postural instability, rigidity, bradykinesia, and a good response to levodopa therapy. Over the last 15 years, numerous studies have confirmed that genetic factors contribute to the complex pathogenesis of PD. Highly penetrant mutations producing rare, monogenic forms of the disease have been discovered in singular genes such as SNCA, Parkin, DJ-1, PINK 1, LRRK2, and VPS35. Unique variants with incomplete penetrance in LRRK2 and GBA have been shown to be strong risk factors for PD in certain populations. Additionally, over 20 common variants with small effect sizes are now recognized to modulate the risk for PD. Investigating Mendelian forms of PD has provided precious insight into the pathophysiology that underlies the more common idiopathic form of disease; however, no treatment methodologies have developed. Furthermore, for identified common risk alleles, the functional basis underlying risk principally remains unknown. The challenge over the next decade will be to strengthen the findings delivered through genetic discovery by assessing the direct, biological consequences of risk variants in tandem with additional high-content, integrated datasets. This review discusses monogenic risk factors and mechanisms of Mendelian inheritance of Parkinson disease. Highly penetrant mutations in SNCA, Parkin, DJ-1, PINK 1, LRRK2 and VPS35 produce rare, monogenic forms of the disease, while unique variants within LRRK2 and GBA show incomplete penetrance and are strong risk factors for PD. Additionally, over 20 common variants with small effect sizes modulate disease risk. The challenge over the next decade is to strengthen genetic findings by assessing direct, biological consequences of risk variants in tandem with high-content, integrated datasets. This article is part of a special issue on Parkinson disease. |
| Author | Reed, Xylena Singleton, Andrew B. Hernandez, Dena G. |
| Author_xml | – sequence: 1 givenname: Dena G. surname: Hernandez fullname: Hernandez, Dena G. organization: German Center for Neurodegenerative Diseases (DZNE)‐Tübingen – sequence: 2 givenname: Xylena surname: Reed fullname: Reed, Xylena organization: National Institute on Aging – sequence: 3 givenname: Andrew B. surname: Singleton fullname: Singleton, Andrew B. email: singleta@mail.nih.gov organization: National Institute on Aging |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27090875$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.neuron.2006.10.008 10.1002/humu.20436 10.1016/j.cub.2005.07.036 10.1111/j.1468-1331.2008.02356.x 10.1056/NEJMc055509 10.1038/ng.300 10.1136/jnnp.70.5.662 10.1212/WNL.0b013e3181f73649 10.1371/journal.pone.0012962 10.1093/brain/awg142 10.1086/319522 10.1038/sj.ejhg.5201455 10.1091/mbc.3.4.415 10.1016/j.bbamcr.2013.07.020 10.1097/NEN.0b013e3181efc01c 10.1016/j.neuron.2004.11.005 10.1111/j.1468-1331.2008.02513.x 10.1212/WNL.48.3.752 10.1080/10715760100300831 10.1086/302486 10.1136/jmg.40.7.543 10.2353/ajpath.2008.070823 10.1007/s10048-005-0005-1 10.1126/science.276.5321.2045 10.1073/pnas.1318306111 10.1083/jcb.200809125 10.1016/S1474-4422(15)00178-7 10.1002/mds.25486 10.1051/medsci/2006225470 10.1016/j.neuron.2009.12.023 10.1212/WNL.44.3_Part_1.437 10.1016/j.parkreldis.2012.04.013 10.1042/BJ20141025 10.1212/01.wnl.0000254458.17630.c5 10.1016/j.bbrc.2009.08.163 10.1002/humu.21277 10.1016/S1474-4422(11)70175-2 10.1002/ana.67 10.1016/S1096-7192(03)00071-4 10.1038/nn.3489 10.1016/j.neuron.2004.10.023 10.1523/JNEUROSCI.1594-04.2004 10.1016/S0140-6736(04)17103-1 10.1016/j.parkreldis.2012.08.007 10.1016/j.parkreldis.2012.05.003 10.1111/j.1399-0004.2007.00781.x 10.1212/01.WNL.0000049470.00180.07 10.1126/science.1096284 10.1002/mds.23968 10.1002/ana.21415 10.1136/jmg.2008.062612 10.1038/sj.embor.7400074 10.1126/science.1195227 10.1111/j.1471-4159.2009.06024.x 10.1002/mds.26243 10.1038/33416 10.1093/brain/awh676 10.1371/journal.pbio.0020362 10.1007/s00702-008-0065-0 10.1097/WNR.0b013e32801254b6 10.1016/j.ajhg.2008.05.005 10.1001/archneur.65.4.514 10.1016/j.bbrc.2004.05.187 10.1001/jamaneurol.2013.172 10.1007/s00018-012-1061-y 10.1007/s100480050083 10.1038/ng.3043 10.1038/ng.642 10.1002/ana.20206 10.1001/archneurol.2008.555 10.1001/jamaneurol.2013.1925 10.1002/ana.10846 10.1080/10715760100301381 10.1002/mds.21658 10.1002/mds.21763 10.1093/brain/awv179 10.1056/NEJMoa1211103 10.1126/science.1109557 10.1016/S0140-6736(04)17104-3 10.1093/hmg/ddr358 10.1038/nn.3350 10.1093/brain/awl005 10.1093/hmg/11.22.2787 10.1007/s10072-003-0108-0 10.1002/ana.410430320 10.1006/bbrc.1997.6132 10.1038/ng.610 10.1001/jama.296.6.661 10.1093/hmg/ddu099 10.1212/01.wnl.0000167546.39375.82 10.1083/jcb.142.3.665 10.1056/NEJM200005253422103 10.1111/tra.12136 10.1038/ng1826 10.1111/j.1469-1809.2009.00560.x 10.1086/496902 10.1038/ng.485 10.1371/journal.pbio.1000298 10.1186/1756-6606-2-5 10.1002/mds.22514 10.1016/j.neuron.2012.11.033 10.1016/j.neurobiolaging.2011.12.035 10.1016/j.bbrc.2004.03.110 10.1212/01.wnl.0000338144.10967.2b 10.1016/j.parkreldis.2009.10.004 10.1002/ana.20753 10.1016/j.neulet.2005.04.103 10.1002/humu.22075 10.1002/ana.10113 10.1091/mbc.E09-09-0801 10.1093/hmg/ddi134 10.1002/humu.20668 10.1083/jcb.151.2.297 10.1155/2014/690796 10.1016/j.parkreldis.2009.11.004 10.1016/j.parkreldis.2012.10.019 10.1002/ana.21380 10.1016/j.ajhg.2011.06.008 10.1016/B978-0-12-800149-3.00005-6 10.1212/01.WNL.0000169023.51764.b0 10.1093/hmg/ddl104 10.1046/j.1440-1789.2003.00476.x 10.1016/j.cub.2005.07.064 10.1093/hmg/ddv340 10.1136/jnnp.2009.194597 10.1001/archneurol.2011.3367 10.1007/s00439-008-0582-9 10.1212/WNL.0b013e3181ff9685 10.1523/JNEUROSCI.5575-11.2012 10.1002/ana.21405 10.1016/j.parkreldis.2009.06.007 10.1212/01.WNL.0000164009.36740.4E 10.1212/01.wnl.0000338435.78120.0f 10.1159/000105160 10.1038/77060 10.1007/s10048-006-0041-5 10.1212/01.wnl.0000327607.28928.e6 10.1523/JNEUROSCI.3799-09.2009 10.1042/BST20120054 10.1038/ncpneuro0126 10.1016/j.parkreldis.2006.12.001 10.1038/ng.608 10.1073/pnas.0402959101 10.1016/S1353-8020(09)70815-6 10.1016/S0140-6736(04)17117-1 10.1212/WNL.0b013e3181b28601 10.1056/NEJMoa1211851 10.1002/mds.23265 10.1002/ana.23614 10.1007/s00439-006-0268-0 10.1002/ajmg.b.30923 10.1056/NEJM198703053161002 10.1212/WNL.0b013e31828727d4 10.1093/brain/awv132 10.1038/ng1884 10.1038/ejhg.2010.254 10.1093/brain/awg136 10.1016/j.parkreldis.2010.11.008 10.1091/mbc.11.12.4105 10.1093/hmg/ddq469 10.1016/j.cell.2011.06.001 10.1111/j.1365-2990.2007.00888.x 10.1016/S1474-4422(08)70117-0 10.1006/mgme.2001.3201 10.1002/humu.9472 10.1212/WNL.56.4.555 10.1086/429256 10.1002/mds.20234 10.1002/humu.21225 10.1016/S0168-9525(01)02410-6 10.1016/j.bbadis.2009.09.010 10.1371/journal.pbio.0020327 10.1002/ana.10675 10.1016/j.cellsig.2005.03.002 10.1212/WNL.0b013e318253d5f2 10.1002/1531-8249(199905)45:5<611::AID-ANA9>3.0.CO;2-X 10.1073/pnas.1112368109 10.1093/hmg/10.16.1649 10.1126/science.277.5324.387 10.1016/j.jmb.2005.12.030 10.1016/j.nbd.2011.12.015 10.1001/archneurol.2010.281 10.1016/S0304-3940(97)00710-6 10.1007/s10048-008-0138-0 10.1002/ana.1132 10.1016/S1474-4422(06)70578-6 10.1093/hmg/11.20.2417 10.1126/science.1090278 10.1056/NEJMc055540 10.1055/s-0031-1299782 10.1038/ng.487 10.1042/BJ20100483 10.1056/NEJMoa033277 10.1073/pnas.1100976108 10.1002/ana.10795 10.1016/j.neulet.2006.09.003 10.1083/jcb.201402104 10.1111/j.1471-4159.2012.07809.x 10.1093/brain/awh667 10.1073/pnas.0710685105 10.1016/j.ajhg.2011.06.001 10.1038/ng0298-106 |
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| References | 2004; 320 2001; 50 2010; 16 2012; 122 1991; 10 2006; 38 2013; 368 2004; 24 2002; 11 1997; 277 1999; 45 2008; 34 2005; 64 2005; 65 2013; 70 2006; 296 2004; 5 2008; 105 2007; 71 2012; 18 2001; 49 2004; 2 2014; 23 2003; 54 1998; 392 2008; 183 2007b; 22 1997; 388 1998; 18 2010; 21 2010; 25 1997a; 48 2015; 138 2008; 29 2000; 11 2006b; 354 2014; 15 2005; 76 2009; 124 2007; 4 2008; 115 2012; 27 2001; 56 2010; 5 2003; 40 2009; 1792 2007; 68 2009; 16 2005; 77 2009; 15 1992; 3 2010; 8 2007; 18 2009; 66 2004; 44 2010; 31 2006; 52 2010; 329 2009; 65 2011; 82 2006; 59 2014; 46 2014; 2014 2012; 33 2004; 304 2007; 13 2006; 354 2012; 32 2012; 109 2006; 356 2008a; 63 2004; 55 2010; 42 2011; 146 2009; 73 2013; 77 2009; 72 2004; 56 2005; 128 2003; 24 2013; 80 2005; 6 2011; 89 2000; 342 2005; 15 2004; 317 2005; 17 2009; 109 2012; 45 2001; 35 1998; 142 2012; 40 2003; 23 2005; 14 2004; 364 2005a; 13 1997; 235 2009; 46 2009; 41 2013; 28 2015; 467 2002; 51 1997; 231 2015; 30 2008; 9 2008; 7 2011; 10 2011; 17 1998; 43 2011; 19 2008; 71 2010; 67 2013; 19 2012; 72 2007; 28 2010; 65 2014; 205 2006; 408 2010; 69 2013; 16 2005; 384 1987; 316 2011; 20 2010; 430 2009; 150B 2008; 65 2001; 17 2003; 126 2012; 69 2006; 129 2007; 22 2006a; 22 2010; 74 1997b; 276 2007a; 120 2001; 10 2004; 101 2013; 1833 2001; 70 2010; 75 2015; 14 2009; 24 2000; 25 2008b; 64 2006; 15 2006; 7 2011; 31 2003; 79 1994; 44 2006; 5 2000; 151 1999; 65 1999; 2 2006; 2 2014; 111 2012; 78 2001; 68 2014; 87 2009; 29 2015; 24 2004; 351 2011; 108 2004; 19 2005b; 308 2003; 60 2003; 302 2009; 2 2008; 82 2009; 389 2001; 73 2008; 172 e_1_2_4_172_1 e_1_2_4_80_1 e_1_2_4_42_1 e_1_2_4_65_1 e_1_2_4_27_1 e_1_2_4_88_1 e_1_2_4_108_1 e_1_2_4_100_1 e_1_2_4_123_1 e_1_2_4_146_1 e_1_2_4_169_1 e_1_2_4_161_1 e_1_2_4_184_1 e_1_2_4_205_1 e_1_2_4_9_1 e_1_2_4_92_1 e_1_2_4_31_1 e_1_2_4_77_1 e_1_2_4_54_1 e_1_2_4_16_1 e_1_2_4_112_1 e_1_2_4_135_1 e_1_2_4_158_1 e_1_2_4_39_1 e_1_2_4_194_1 e_1_2_4_196_1 e_1_2_4_171_1 e_1_2_4_81_1 e_1_2_4_20_1 e_1_2_4_66_1 e_1_2_4_43_1 e_1_2_4_107_1 e_1_2_4_89_1 e_1_2_4_28_1 e_1_2_4_145_1 e_1_2_4_168_1 e_1_2_4_122_1 e_1_2_4_183_1 e_1_2_4_160_1 e_1_2_4_2_1 e_1_2_4_70_1 e_1_2_4_93_1 e_1_2_4_32_1 e_1_2_4_55_1 e_1_2_4_78_1 e_1_2_4_119_1 e_1_2_4_17_1 e_1_2_4_134_1 e_1_2_4_157_1 e_1_2_4_111_1 e_1_2_4_195_1 e_1_2_4_170_1 e_1_2_4_82_1 e_1_2_4_21_1 e_1_2_4_44_1 e_1_2_4_67_1 e_1_2_4_106_1 e_1_2_4_129_1 e_1_2_4_29_1 e_1_2_4_167_1 e_1_2_4_121_1 e_1_2_4_144_1 e_1_2_4_182_1 e_1_2_4_7_1 e_1_2_4_94_1 e_1_2_4_203_1 e_1_2_4_71_1 e_1_2_4_10_1 e_1_2_4_56_1 e_1_2_4_33_1 e_1_2_4_118_1 e_1_2_4_79_1 e_1_2_4_18_1 e_1_2_4_156_1 e_1_2_4_179_1 e_1_2_4_192_1 e_1_2_4_133_1 e_1_2_4_83_1 e_1_2_4_60_1 e_1_2_4_45_1 e_1_2_4_22_1 e_1_2_4_105_1 e_1_2_4_128_1 e_1_2_4_68_1 e_1_2_4_189_1 e_1_2_4_120_1 e_1_2_4_166_1 e_1_2_4_143_1 e_1_2_4_204_1 e_1_2_4_181_1 e_1_2_4_95_1 e_1_2_4_8_1 e_1_2_4_72_1 e_1_2_4_11_1 e_1_2_4_34_1 e_1_2_4_117_1 e_1_2_4_57_1 e_1_2_4_19_1 e_1_2_4_178_1 e_1_2_4_155_1 e_1_2_4_193_1 e_1_2_4_132_1 e_1_2_4_199_1 e_1_2_4_84_1 e_1_2_4_61_1 e_1_2_4_23_1 e_1_2_4_127_1 e_1_2_4_46_1 e_1_2_4_69_1 e_1_2_4_104_1 e_1_2_4_142_1 e_1_2_4_165_1 e_1_2_4_188_1 e_1_2_4_180_1 e_1_2_4_5_1 e_1_2_4_96_1 e_1_2_4_73_1 e_1_2_4_50_1 e_1_2_4_201_1 e_1_2_4_12_1 e_1_2_4_116_1 e_1_2_4_139_1 e_1_2_4_35_1 e_1_2_4_58_1 e_1_2_4_190_1 e_1_2_4_131_1 e_1_2_4_154_1 e_1_2_4_177_1 e_1_2_4_85_1 e_1_2_4_62_1 e_1_2_4_24_1 e_1_2_4_149_1 e_1_2_4_47_1 e_1_2_4_126_1 e_1_2_4_103_1 e_1_2_4_141_1 e_1_2_4_187_1 e_1_2_4_164_1 e_1_2_4_6_1 e_1_2_4_51_1 e_1_2_4_74_1 e_1_2_4_202_1 e_1_2_4_13_1 e_1_2_4_36_1 e_1_2_4_59_1 e_1_2_4_97_1 e_1_2_4_138_1 e_1_2_4_115_1 e_1_2_4_191_1 e_1_2_4_130_1 e_1_2_4_176_1 e_1_2_4_153_1 e_1_2_4_151_1 e_1_2_4_197_1 Mizutani Y. (e_1_2_4_110_1) 1991; 10 e_1_2_4_40_1 e_1_2_4_63_1 e_1_2_4_25_1 e_1_2_4_48_1 e_1_2_4_86_1 e_1_2_4_125_1 e_1_2_4_148_1 e_1_2_4_102_1 e_1_2_4_163_1 e_1_2_4_186_1 e_1_2_4_140_1 e_1_2_4_3_1 e_1_2_4_52_1 e_1_2_4_90_1 e_1_2_4_75_1 e_1_2_4_14_1 e_1_2_4_98_1 e_1_2_4_37_1 e_1_2_4_114_1 e_1_2_4_137_1 e_1_2_4_152_1 e_1_2_4_175_1 e_1_2_4_150_1 e_1_2_4_173_1 e_1_2_4_198_1 e_1_2_4_41_1 e_1_2_4_109_1 e_1_2_4_64_1 e_1_2_4_49_1 e_1_2_4_87_1 e_1_2_4_26_1 e_1_2_4_124_1 e_1_2_4_147_1 e_1_2_4_101_1 e_1_2_4_185_1 e_1_2_4_162_1 e_1_2_4_4_1 e_1_2_4_30_1 e_1_2_4_91_1 e_1_2_4_200_1 e_1_2_4_53_1 e_1_2_4_76_1 e_1_2_4_15_1 e_1_2_4_38_1 e_1_2_4_99_1 e_1_2_4_113_1 e_1_2_4_159_1 e_1_2_4_136_1 e_1_2_4_174_1 |
| References_xml | – volume: 35 start-page: 301 year: 2001 end-page: 310 article-title: Oxidized forms of peroxiredoxins and DJ‐1 on two‐dimensional gels increased in response to sublethal levels of paraquat publication-title: Free Radic. Res. – volume: 13 start-page: 1086 year: 2005a end-page: 1093 article-title: PINK1, Parkin, and DJ‐1 mutations in Italian patients with early‐onset parkinsonism publication-title: Eur. J. Hum. Genet. – volume: 46 start-page: 458 year: 2009 end-page: 464 article-title: Molecular analyses of the LRRK2 gene in European and North African autosomal dominant Parkinson's disease publication-title: J. Med. Genet. – volume: 15 start-page: 230 year: 2014 end-page: 244 article-title: The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromer publication-title: Traffic – volume: 41 start-page: 1308 year: 2009 end-page: 1312 article-title: Genome‐wide association study reveals genetic risk underlying Parkinson's disease publication-title: Nat. Genet. – volume: 317 start-page: 722 year: 2004 end-page: 728 article-title: Cysteine‐106 of DJ‐1 is the most sensitive cysteine residue to hydrogen peroxide‐mediated oxidation in vivo in human umbilical vein endothelial cells publication-title: Biochem. Biophys. Res. Commun. – volume: 15 start-page: 1572 year: 2005 end-page: 1577 article-title: Drosophila DJ‐1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease publication-title: Curr. Biol. – volume: 105 start-page: 145 year: 2008 end-page: 150 article-title: The Parkinson's disease protein alpha‐synuclein disrupts cellular Rab homeostasis publication-title: Proc. Natl Acad. Sci. USA – volume: 89 start-page: 162 year: 2011 end-page: 167 article-title: VPS35 mutations in Parkinson disease publication-title: Am. J. Hum. Genet. – volume: 29 start-page: 485 year: 2008 end-page: 490 article-title: Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls publication-title: Hum. Mutat. – volume: 35 start-page: 885 year: 2001 end-page: 893 article-title: DJ‐1 is an indicator for endogenous reactive oxygen species elicited by endotoxin publication-title: Free Radic. Res. – volume: 64 start-page: 88 year: 2008b end-page: 92 article-title: Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease publication-title: Ann. Neurol. – volume: 24 start-page: 6715 year: 2004 end-page: 6723 article-title: Lipid rafts mediate the synaptic localization of alpha‐synuclein publication-title: J. Neurosci. – volume: 77 start-page: 425 year: 2013 end-page: 439 article-title: RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk publication-title: Neuron – volume: 82 start-page: 1179 year: 2011 end-page: 1180 article-title: Frequencies of LRRK2 variants in Thai patients with Parkinson's disease: evidence for an R1628P founder publication-title: J. Neurol. Neurosurg. Psychiatry – volume: 5 start-page: 911 year: 2006 end-page: 916 article-title: Genome‐wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data publication-title: Lancet Neurol. – volume: 16 start-page: 85 year: 2010 end-page: 88 article-title: The LRRK2 G2385R variant is a risk factor for sporadic Parkinson's disease in the Korean population publication-title: Parkinsonism Relat. Disord. – volume: 54 start-page: 283 year: 2003 end-page: 286 article-title: The role of pathogenic DJ‐1 mutations in Parkinson's disease publication-title: Ann. Neurol. – volume: 48 start-page: 752 year: 1997a end-page: 757 article-title: Linkage of the locus for cerebral cavernous hemangiomas to human chromosome 7q in four families of Mexican‐American descent publication-title: Neurology – volume: 55 start-page: 164 year: 2004 end-page: 173 article-title: The new mutation, E46K, of alpha‐synuclein causes Parkinson and Lewy body dementia publication-title: Ann. Neurol. – volume: 15 start-page: S205 issue: Suppl 3 year: 2009 end-page: S208 article-title: Clinical features of LRRK2 parkinsonism publication-title: Parkinsonism Relat. Disord. – volume: 392 start-page: 605 year: 1998 end-page: 608 article-title: Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism publication-title: Nature – volume: 11 start-page: 2787 year: 2002 end-page: 2792 article-title: Functional association of the parkin gene promoter with idiopathic Parkinson's disease publication-title: Hum. Mol. Genet. – volume: 101 start-page: 9103 year: 2004 end-page: 9108 article-title: The Parkinson's disease protein DJ‐1 is neuroprotective due to cysteine‐sulfinic acid‐driven mitochondrial localization publication-title: Proc. Natl Acad. Sci. USA – volume: 2 start-page: e362 year: 2004 article-title: DJ‐1 is a redox‐dependent molecular chaperone that inhibits alpha‐synuclein aggregate formation publication-title: PLoS Biol. – volume: 72 start-page: 455 year: 2012 end-page: 463 article-title: Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains publication-title: Ann. Neurol. – volume: 13 start-page: 89 year: 2007 end-page: 92 article-title: Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia publication-title: Parkinsonism Relat. Disord. – volume: 277 start-page: 387 year: 1997 end-page: 388 article-title: Genetic complexity and Parkinson's disease. Deane Laboratory Parkinson Disease Research Group publication-title: Science – volume: 231 start-page: 509 year: 1997 end-page: 513 article-title: DJ‐1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras publication-title: Biochem. Biophys. Res. Commun. – volume: 44 start-page: 595 year: 2004 end-page: 600 article-title: Cloning of the gene containing mutations that cause PARK8‐linked Parkinson's disease publication-title: Neuron – volume: 41 start-page: 1303 year: 2009 end-page: 1307 article-title: Genome‐wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease publication-title: Nat. Genet. – volume: 138 start-page: 2648 issue: Pt 9 year: 2015 end-page: 2658 article-title: Glucocerebrosidase activity in Parkinson's disease with and without GBA mutations publication-title: Brain – volume: 44 start-page: 437 issue: 3 Pt 1 year: 1994 end-page: 441 article-title: Familial juvenile parkinsonism: clinical and pathologic study in a family publication-title: Neurology – volume: 17 start-page: 1052 year: 2005 end-page: 1062 article-title: Cellular regulation and proposed biological functions of group VIA calcium‐independent phospholipase A2 in activated cells publication-title: Cell. Signal. – volume: 10 start-page: 898 year: 2011 end-page: 908 article-title: Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case‐control study publication-title: Lancet Neurol. – volume: 296 start-page: 661 year: 2006 end-page: 670 article-title: Collaborative analysis of alpha‐synuclein gene promoter variability and Parkinson disease publication-title: JAMA – volume: 34 start-page: 272 year: 2008 end-page: 283 article-title: LRRK2 is a component of granular alpha‐synuclein pathology in the brainstem of Parkinson's disease publication-title: Neuropathol. Appl. Neurobiol. – volume: 40 start-page: 543 year: 2003 end-page: 546 article-title: Karak syndrome: a novel degenerative disorder of the basal ganglia and cerebellum publication-title: J. Med. Genet. – volume: 2 start-page: 191 year: 1999 end-page: 192 article-title: The alpha‐synuclein gene is not a major risk factor in familial Parkinson disease publication-title: Neurogenetics – volume: 55 start-page: 174 year: 2004 end-page: 179 article-title: Comparison of kindreds with parkinsonism and alpha‐synuclein genomic multiplications publication-title: Ann. Neurol. – volume: 42 start-page: 565 year: 2010 end-page: 569 article-title: Common SNPs explain a large proportion of the heritability for human height publication-title: Nat. Genet. – volume: 16 start-page: 237 year: 2010 end-page: 242 article-title: Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: a systematic review publication-title: Parkinsonism Relat. Disord. – volume: 2 start-page: 5 year: 2009 article-title: Cathepsin D expression level affects alpha‐synuclein processing, aggregation, and toxicity in vivo publication-title: Mol. Brain – volume: 73 start-page: 1424 year: 2009 end-page: 1425 article-title: Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset publication-title: Neurology – volume: 24 start-page: 159 year: 2003 end-page: 160 article-title: DJ‐1(PARK7), a novel gene for autosomal recessive, early onset parkinsonism publication-title: Neurol. Sci. – volume: 14 start-page: 1002 year: 2015 end-page: 1009 article-title: Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population‐based modelling study publication-title: Lancet Neurol. – volume: 67 start-page: 1357 year: 2010 end-page: 1363 article-title: Recessively inherited parkinsonism: effect of ATP13A2 mutations on the clinical and neuroimaging phenotype publication-title: Arch. Neurol. – volume: 28 start-page: 27 year: 2007 end-page: 32 article-title: Deletion of the parkin and PACRG gene promoter in early‐onset parkinsonism publication-title: Hum. Mutat. – volume: 31 start-page: 433 year: 2011 end-page: 440 article-title: Genetics of Parkinson's disease publication-title: Semin. Neurol. – volume: 20 start-page: 345 year: 2011 end-page: 353 article-title: Dissection of the genetics of Parkinson's disease identifies an additional association 5′ of SNCA and multiple associated haplotypes at 17q21 publication-title: Hum. Mol. Genet. – volume: 16 start-page: 101 year: 2009 end-page: 104 article-title: R632W mutation in PLA2G6 segregates with dystonia‐parkinsonism in a consanguineous Iranian family publication-title: Eur. J. Neurol. – volume: 41 start-page: 308 year: 2009 end-page: 315 article-title: Alpha‐synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity publication-title: Nat. Genet. – volume: 11 start-page: 2417 year: 2002 end-page: 2423 article-title: The allelic architecture of human disease genes: common disease‐common variant. or not? publication-title: Hum. Mol. Genet. – volume: 73 start-page: 313 year: 2001 end-page: 321 article-title: Gaucher disease and parkinsonism: a phenotypic and genotypic characterization publication-title: Mol. Genet. Metab. – volume: 31 start-page: 561 year: 2010 end-page: 568 article-title: Multiple LRRK2 variants modulate risk of Parkinson disease: a Chinese multicenter study publication-title: Hum. Mutat. – volume: 89 start-page: 168 year: 2011 end-page: 175 article-title: A mutation in VPS35, encoding a subunit of the retromer complex, causes late‐onset Parkinson disease publication-title: Am. J. Hum. Genet. – volume: 2 start-page: e327 year: 2004 article-title: Sensitivity to oxidative stress in DJ‐1‐deficient dopamine neurons: an ES‐ derived cell model of primary Parkinsonism publication-title: PLoS Biol. – volume: 19 start-page: 251 year: 2013 end-page: 255 article-title: Genetic variants of SNCA and LRRK2 genes are associated with sporadic PD susceptibility: a replication study in a Taiwanese cohort publication-title: Parkinsonism Relat. Disord. – volume: 56 start-page: 555 year: 2001 end-page: 557 article-title: Clinical and pathologic abnormalities in a family with parkinsonism and parkin gene mutations publication-title: Neurology – volume: 1792 start-page: 1194 year: 2009 end-page: 1197 article-title: The R1441C mutation alters the folding properties of the ROC domain of LRRK2 publication-title: Biochim. Biophys. Acta – volume: 28 start-page: 702 year: 2013 end-page: 704 article-title: Parkin disease and the Lewy body conundrum publication-title: Mov. Disord. – volume: 69 start-page: 959 year: 2010 end-page: 972 article-title: Leucine‐rich repeat kinase 2 is associated with the endoplasmic reticulum in dopaminergic neurons and accumulates in the core of Lewy bodies in Parkinson disease publication-title: J. Neuropathol. Exp. Neurol. – volume: 308 start-page: 385 year: 2005b end-page: 389 article-title: Complement factor H polymorphism in age‐related macular degeneration publication-title: Science – volume: 82 start-page: 1375 year: 2008 end-page: 1384 article-title: Genome‐wide linkage analysis of a Parkinsonian‐pyramidal syndrome pedigree by 500 K SNP arrays publication-title: Am. J. Hum. Genet. – volume: 19 start-page: 655 year: 2011 end-page: 661 article-title: Genome‐wide association study confirms extant PD risk loci among the Dutch publication-title: Eur. J. Hum. Genet. – volume: 16 start-page: 297 year: 2009 end-page: 309 article-title: Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options publication-title: Eur. J. Neurol. – volume: 71 start-page: 471 year: 2007 end-page: 473 article-title: The Ala53Thr mutation in the alpha‐synuclein gene in a Korean family with Parkinson disease publication-title: Clin. Genet. – volume: 31 start-page: 763 year: 2010 end-page: 780 article-title: Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update publication-title: Hum. Mutat. – volume: 42 start-page: 570 year: 2010 end-page: 575 article-title: Estimation of effect size distribution from genome‐wide association studies and implications for future discoveries publication-title: Nat. Genet. – volume: 63 start-page: 743 year: 2008a end-page: 750 article-title: Genomic investigation of alpha‐synuclein multiplication and parkinsonism publication-title: Ann. Neurol. – volume: 65 start-page: 66 year: 2010 end-page: 79 article-title: Increased expression of alpha‐synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis publication-title: Neuron – volume: 51 start-page: 296 year: 2002 end-page: 301 article-title: A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2‐q13.1 publication-title: Ann. Neurol. – volume: 109 start-page: 9611 year: 2012 end-page: 9616 article-title: Loss of P‐type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration publication-title: Proc. Natl Acad. Sci. USA – volume: 430 start-page: 393 year: 2010 end-page: 404 article-title: 14‐3‐3 binding to LRRK2 is disrupted by multiple Parkinson's disease‐associated mutations and regulates cytoplasmic localization publication-title: Biochem. J. – volume: 115 start-page: 1275 year: 2008 end-page: 1277 article-title: LRRK2 Gly2385Arg mutation and clinical features in a Chinese population with early‐onset Parkinson's disease compared to late‐onset patients publication-title: J. Neural. Transm. – volume: 65 start-page: 19 year: 2009 end-page: 23 article-title: Characterization of PLA2G6 as a locus for dystonia‐parkinsonism publication-title: Ann. Neurol. – volume: 24 start-page: 1034 year: 2009 end-page: 1041 article-title: LRRK2 mutations and risk variants in Japanese patients with Parkinson's disease publication-title: Mov. Disord. – volume: 71 start-page: 1289 year: 2008 end-page: 1291 article-title: Prominent psychiatric symptoms and glucose hypometabolism in a family with a SNCA duplication publication-title: Neurology – volume: 2014 start-page: 690796 year: 2014 article-title: Alternative splicing generates different parkin protein isoforms: evidences in human, rat, and mouse brain publication-title: Biomed. Res. Int. – volume: 7 start-page: 133 year: 2006 end-page: 138 article-title: A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan publication-title: Neurogenetics – volume: 356 start-page: 1036 year: 2006 end-page: 1048 article-title: The oxidation state of DJ‐1 regulates its chaperone activity toward alpha‐synuclein publication-title: J. Mol. Biol. – volume: 151 start-page: 297 year: 2000 end-page: 310 article-title: Sorting of yeast membrane proteins into an endosome‐to‐Golgi pathway involves direct interaction of their cytosolic domains with Vps35p publication-title: J. Cell Biol. – volume: 65 start-page: 87 year: 2005 end-page: 95 article-title: Early‐onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes publication-title: Neurology – volume: 64 start-page: 1955 year: 2005 end-page: 1957 article-title: Clinicogenetic study of PINK1 mutations in autosomal recessive early‐onset parkinsonism publication-title: Neurology – volume: 75 start-page: 1356 year: 2010 end-page: 1361 article-title: Phenotypic spectrum of patients with PLA2G6 mutation and PARK14‐linked parkinsonism publication-title: Neurology – volume: 120 start-page: 857 year: 2007a end-page: 863 article-title: The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence publication-title: Hum. Genet. – volume: 38 start-page: 752 year: 2006 end-page: 754 article-title: PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron publication-title: Nat. Genet. – volume: 389 start-page: 449 year: 2009 end-page: 454 article-title: The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites publication-title: Biochem. Biophys. Res. Commun. – volume: 65 start-page: 555 year: 1999 end-page: 558 article-title: Genetic analysis of families with Parkinson disease that carry the Ala53Thr mutation in the gene encoding alpha‐synuclein publication-title: Am. J. Hum. Genet. – volume: 138 start-page: 1801 issue: Pt 7 year: 2015 end-page: 1816 article-title: Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction publication-title: Brain – volume: 60 start-page: 796 year: 2003 end-page: 801 article-title: Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease publication-title: Neurology – volume: 126 start-page: 1271 issue: Pt 6 year: 2003 end-page: 1278 article-title: Parkin mutations are frequent in patients with isolated early‐onset parkinsonism publication-title: Brain – volume: 16 start-page: 394 year: 2013 end-page: 406 article-title: Interplay of LRRK2 with chaperone‐mediated autophagy publication-title: Nat. Neurosci. – volume: 77 start-page: 685 year: 2005 end-page: 693 article-title: High‐resolution whole‐genome association study of Parkinson disease publication-title: Am. J. Hum. Genet. – volume: 2 start-page: 136 year: 2006 end-page: 146 article-title: The genetics of Parkinson disease: implications for neurological care publication-title: Nat. Clin. Pract. Neurol. – volume: 43 start-page: 394 year: 1998 end-page: 397 article-title: Low frequency of alpha‐synuclein mutations in familial Parkinson's disease publication-title: Ann. Neurol. – volume: 18 start-page: 722 year: 2012 end-page: 730 article-title: Quantitative assessment of the effect of LRRK2 exonic variants on the risk of Parkinson's disease: a meta‐analysis publication-title: Parkinsonism Relat. Disord. – volume: 467 start-page: 303 year: 2015 end-page: 310 article-title: DJ1 represses glycolysis and cell proliferation by transcriptionally up‐regulating Pink1 publication-title: Biochem. J. – volume: 22 start-page: 2439 year: 2007 end-page: 2443 article-title: The prevalence of LRRK2 Gly2385Arg variant in Chinese Han population with Parkinson's disease publication-title: Mov. Disord. – volume: 205 start-page: 143 year: 2014 end-page: 153 article-title: PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity publication-title: J. Cell Biol. – volume: 14 start-page: 1231 year: 2005 end-page: 1241 article-title: The Parkinson's disease‐associated DJ‐1 protein is a transcriptional co‐activator that protects against neuronal apoptosis publication-title: Hum. Mol. Genet. – volume: 71 start-page: 1295 year: 2008 article-title: Re: alpha‐synuclein gene duplication is present in sporadic Parkinson disease publication-title: Neurology – volume: 329 start-page: 1663 year: 2010 end-page: 1667 article-title: Alpha‐synuclein promotes SNARE‐complex assembly in vivo and in vitro publication-title: Science – volume: 33 start-page: 1087 year: 2012 end-page: 1098 article-title: Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe publication-title: Hum. Mutat. – volume: 9 start-page: 263 year: 2008 end-page: 269 article-title: Analysis of PARK genes in a Korean cohort of early‐onset Parkinson disease publication-title: Neurogenetics – volume: 7 start-page: 583 year: 2008 end-page: 590 article-title: Phenotype, genotype, and worldwide genetic penetrance of LRRK2‐associated Parkinson's disease: a case‐control study publication-title: Lancet Neurol – volume: 109 start-page: 959 year: 2009 end-page: 968 article-title: The Parkinson disease‐associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro publication-title: J. Neurochem. – volume: 27 start-page: 146 year: 2012 end-page: 151 article-title: LRRK2 haplotype‐sharing analysis in Parkinson's disease reveals a novel p. S1761R mutation publication-title: Mov. Disord. – volume: 17 start-page: 501 year: 2011 end-page: 508 article-title: Genetic characteristics of leucine‐rich repeat kinase 2 (LRRK2) associated Parkinson's disease publication-title: Parkinsonism Relat. Disord. – volume: 25 start-page: 2156 year: 2010 end-page: 2163 article-title: Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease publication-title: Mov. Disord. – volume: 128 start-page: 2760 issue: Pt 12 year: 2005 end-page: 2762 article-title: Genetics of Parkinson's disease: LRRK2 on the rise publication-title: Brain – volume: 183 start-page: 795 year: 2008 end-page: 803 article-title: Parkin is recruited selectively to impaired mitochondria and promotes their autophagy publication-title: J. Cell Biol. – volume: 23 start-page: 2816 year: 2014 end-page: 2833 article-title: Parkinson's disease‐linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes alpha‐Synuclein externalization via exosomes publication-title: Hum. Mol. Genet. – volume: 66 start-page: 102 year: 2009 end-page: 108 article-title: Alpha‐synuclein gene rearrangements in dominantly inherited parkinsonism: frequency, phenotype, and mechanisms publication-title: Arch. Neurol. – volume: 80 start-page: 982 year: 2013 end-page: 989 article-title: Whole exome sequencing of rare variants in EIF4G1 and VPS35 in Parkinson disease publication-title: Neurology – volume: 22 start-page: 1816 year: 2007b end-page: 1818 article-title: Analysis of LRRK2 Gly2385Arg genetic variant in non‐Chinese Asians publication-title: Mov. Disord. – volume: 368 start-page: 107 year: 2013 end-page: 116 article-title: Variant of TREM2 associated with the risk of Alzheimer's disease publication-title: N. Engl. J. Med. – volume: 4 start-page: 386 year: 2007 end-page: 391 article-title: Comprehensive screening of a North American Parkinson's disease cohort for LRRK2 mutation publication-title: Neurodegener. Dis. – volume: 364 start-page: 1105 year: 2004 end-page: 1107 article-title: Parkinson's disease and dementia with Lewy bodies: a difference in dose? publication-title: Lancet – volume: 5 start-page: 213 year: 2004 end-page: 218 article-title: DJ‐1 has a role in antioxidative stress to prevent cell death publication-title: EMBO Rep. – volume: 128 start-page: 2786 issue: Pt 12 year: 2005 end-page: 2796 article-title: Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data publication-title: Brain – volume: 44 start-page: 601 year: 2004 end-page: 607 article-title: Mutations in LRRK2 cause autosomal‐dominant parkinsonism with pleomorphic pathology publication-title: Neuron – volume: 15 start-page: 627 year: 2009 end-page: 632 article-title: A Swedish family with de novo alpha‐synuclein A53T mutation: evidence for early cortical dysfunction publication-title: Parkinsonism Relat. Disord. – volume: 70 start-page: 121 year: 2013 end-page: 136 article-title: The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway publication-title: Cell. Mol. Life Sci. – volume: 146 start-page: 37 year: 2011 end-page: 52 article-title: Gaucher disease glucocerebrosidase and alpha‐synuclein form a bidirectional pathogenic loop in synucleinopathies publication-title: Cell – volume: 24 start-page: 6314 year: 2015 end-page: 6330 article-title: F‐box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy publication-title: Hum. Mol. Genet. – volume: 172 start-page: 406 year: 2008 end-page: 416 article-title: Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations publication-title: Am. J. Pathol. – volume: 18 start-page: 273 year: 2007 end-page: 275 article-title: Leucine‐rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population publication-title: NeuroReport – volume: 75 start-page: 2017 year: 2010 end-page: 2020 article-title: Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2 publication-title: Neurology – volume: 52 start-page: 587 year: 2006 end-page: 593 article-title: The familial Parkinsonism gene LRRK2 regulates neurite process morphology publication-title: Neuron – volume: 17 start-page: 502 year: 2001 end-page: 510 article-title: On the allelic spectrum of human disease publication-title: Trends Genet. – volume: 354 start-page: 422 year: 2006b end-page: 423 article-title: LRRK2 G2019S as a cause of Parkinson's disease in North African Arabs publication-title: N. Engl. J. Med. – volume: 79 start-page: 104 year: 2003 end-page: 109 article-title: Gaucher disease with parkinsonian manifestations: does glucocerebrosidase deficiency contribute to a vulnerability to parkinsonism? publication-title: Mol. Genet. Metab. – volume: 72 start-page: 240 year: 2009 end-page: 245 article-title: FBXO7 mutations cause autosomal recessive, early‐onset parkinsonian‐pyramidal syndrome publication-title: Neurology – volume: 320 start-page: 389 year: 2004 end-page: 397 article-title: Reduced anti‐oxidative stress activities of DJ‐1 mutants found in Parkinson's disease patients publication-title: Biochem. Biophys. Res. Commun. – volume: 45 start-page: 962 year: 2012 end-page: 972 article-title: ATP13A2 regulates mitochondrial bioenergetics through macroautophagy publication-title: Neurobiol. Dis. – volume: 15 start-page: 1578 year: 2005 end-page: 1582 article-title: Roles of Drosophila DJ‐1 in survival of dopaminergic neurons and oxidative stress publication-title: Curr. Biol. – volume: 364 start-page: 1169 year: 2004 end-page: 1171 article-title: Causal relation between alpha‐synuclein gene duplication and familial Parkinson's disease publication-title: Lancet – volume: 342 start-page: 1560 year: 2000 end-page: 1567 article-title: Association between early‐onset Parkinson's disease and mutations in the parkin gene publication-title: N. Engl. J. Med. – volume: 388 start-page: 839 year: 1997 end-page: 840 article-title: Alpha‐synuclein in Lewy bodies publication-title: Nature – volume: 1833 start-page: 2900 year: 2013 end-page: 2910 article-title: Inhibition of LRRK2 kinase activity stimulates macroautophagy publication-title: Biochim. Biophys. Acta – volume: 11 start-page: 4105 year: 2000 end-page: 4116 article-title: Human orthologs of yeast vacuolar protein sorting proteins Vps 26, 29, and 35: assembly into multimeric complexes publication-title: Mol. Biol. Cell – volume: 59 start-page: 298 year: 2006 end-page: 309 article-title: Clinical heterogeneity of alpha‐synuclein gene duplication in Parkinson's disease publication-title: Ann. Neurol. – volume: 124 start-page: 593 year: 2009 end-page: 605 article-title: Genomewide association study for susceptibility genes contributing to familial Parkinson disease publication-title: Hum. Genet. – volume: 142 start-page: 665 year: 1998 end-page: 681 article-title: A membrane coat complex essential for endosome‐to‐Golgi retrograde transport in yeast publication-title: J. Cell Biol. – volume: 46 start-page: 989 year: 2014 end-page: 993 article-title: Large‐scale meta‐analysis of genome‐wide association data identifies six new risk loci for Parkinson's disease publication-title: Nat. Genet. – volume: 70 start-page: 662 year: 2001 end-page: 665 article-title: Clinical phenotype in patients with alpha‐synuclein Parkinson's disease living in Greece in comparison with patients with sporadic Parkinson's disease publication-title: J. Neurol. Neurosurg. Psychiatry – volume: 15 start-page: 1816 year: 2006 end-page: 1825 article-title: Association of PINK1 and DJ‐1 confers digenic inheritance of early‐onset Parkinson's disease publication-title: Hum. Mol. Genet. – volume: 18 start-page: 958 year: 2012 end-page: 963 article-title: Penetrance of LRRK2 G2385R and R1628P is modified by common PD‐associated genetic variants publication-title: Parkinsonism Relat. Disord. – volume: 78 start-page: 1449 year: 2012 end-page: 1450 article-title: Identification of VPS35 mutations replicated in French families with Parkinson disease publication-title: Neurology – volume: 68 start-page: 895 year: 2001 end-page: 900 article-title: Localization of a novel locus for autosomal recessive early‐onset parkinsonism, PARK6, on human chromosome 1p35‐p36 publication-title: Am. J. Hum. Genet. – volume: 126 start-page: 1279 issue: Pt 6 year: 2003 end-page: 1292 article-title: Parkin disease: a phenotypic study of a large case series publication-title: Brain – volume: 28 start-page: 98 year: 2007 article-title: Whole gene deletion and splicing mutations expand the PINK1 genotypic spectrum publication-title: Hum. Mutat. – volume: 38 start-page: 1184 year: 2006 end-page: 1191 article-title: Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P‐type ATPase publication-title: Nat. Genet. – volume: 302 start-page: 841 year: 2003 article-title: alpha‐Synuclein locus triplication causes Parkinson's disease publication-title: Science – volume: 368 start-page: 117 year: 2013 end-page: 127 article-title: TREM2 variants in Alzheimer's disease publication-title: N. Engl. J. Med. – volume: 42 start-page: 781 year: 2010 end-page: 785 article-title: Common genetic variation in the HLA region is associated with late‐onset sporadic Parkinson's disease publication-title: Nat. Genet. – volume: 408 start-page: 209 year: 2006 end-page: 213 article-title: Mutations in DJ‐1 are rare in familial Parkinson disease publication-title: Neurosci. Lett. – volume: 68 start-page: 916 year: 2007 end-page: 922 article-title: Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication publication-title: Neurology – volume: 29 start-page: 13971 year: 2009 end-page: 13980 article-title: Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis publication-title: J. Neurosci. – volume: 3 start-page: 415 year: 1992 end-page: 427 article-title: Alternative pathways for the sorting of soluble vacuolar proteins in yeast: a vps35 null mutant missorts and secretes only a subset of vacuolar hydrolases publication-title: Mol. Biol. Cell – volume: 65 start-page: 514 year: 2008 end-page: 519 article-title: Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia publication-title: Arch. Neurol. – volume: 40 start-page: 1058 year: 2012 end-page: 1062 article-title: Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease publication-title: Biochem. Soc. Trans. – volume: 49 start-page: 313 year: 2001 end-page: 319 article-title: Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha‐synuclein mutation publication-title: Ann. Neurol. – volume: 25 start-page: 302 year: 2000 end-page: 305 article-title: Familial Parkinson disease gene product, parkin, is a ubiquitin‐protein ligase publication-title: Nat. Genet. – volume: 56 start-page: 329 year: 2004 end-page: 335 article-title: The gene responsible for PARK6 Parkinson's disease, PINK1, does not influence common forms of parkinsonism publication-title: Ann. Neurol. – volume: 87 start-page: 245 year: 2014 end-page: 294 article-title: Genetics of Alzheimer's disease publication-title: Adv. Genet. – volume: 22 start-page: 470 year: 2006a end-page: 471 article-title: LRRK2 is a major gene in North African parkinsonism publication-title: Med. Sci. (Paris) – volume: 304 start-page: 1158 year: 2004 end-page: 1160 article-title: Hereditary early‐onset Parkinson's disease caused by mutations in PINK1 publication-title: Science – volume: 10 start-page: 91 year: 1991 end-page: 97 article-title: Juvenile parkinsonism: a case with first clinical manifestation at the age of six years and with neuropathological findings suggesting a new pathogenesis publication-title: Clin. Neuropathol. – volume: 111 start-page: 2626 year: 2014 end-page: 2631 article-title: Unbiased screen for interactors of leucine‐rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease publication-title: Proc. Natl Acad. Sci. USA – volume: 74 start-page: 97 year: 2010 end-page: 109 article-title: Genome‐wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease publication-title: Ann. Hum. Genet. – volume: 21 start-page: 1850 year: 2010 end-page: 1863 article-title: Alpha‐synuclein delays endoplasmic reticulum (ER)‐to‐Golgi transport in mammalian cells by antagonizing ER/Golgi SNAREs publication-title: Mol. Biol. Cell – volume: 70 start-page: 727 year: 2013 end-page: 735 article-title: A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies publication-title: JAMA Neurol. – volume: 8 start-page: e1000298 year: 2010 article-title: PINK1 is selectively stabilized on impaired mitochondria to activate Parkin publication-title: PLoS Biol. – volume: 122 start-page: 650 year: 2012 end-page: 658 article-title: Leucine‐rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin‐like protein publication-title: J. Neurochem. – volume: 108 start-page: 4194 year: 2011 end-page: 4199 article-title: In vivo demonstration that alpha‐synuclein oligomers are toxic publication-title: Proc. Natl Acad. Sci. USA – volume: 20 start-page: R158‐62 issue: R2 year: 2011 article-title: A generalizable hypothesis for the genetic architecture of disease: pleomorphic risk loci publication-title: Hum. Mol. Genet. – volume: 16 start-page: 1257 year: 2013 end-page: 1265 article-title: The Parkinson's disease‐linked proteins Fbxo7 and Parkin interact to mediate mitophagy publication-title: Nat. Neurosci. – volume: 69 start-page: 1360 year: 2012 end-page: 1364 article-title: Frequency of the D620N mutation in VPS35 in Parkinson disease publication-title: Arch. Neurol. – volume: 32 start-page: 4240 year: 2012 end-page: 4246 article-title: Deficiency of ATP13A2 leads to lysosomal dysfunction, alpha‐synuclein accumulation, and neurotoxicity publication-title: J. Neurosci. – volume: 354 start-page: 424 year: 2006 end-page: 425 article-title: LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews publication-title: N. Engl. J. Med. – volume: 19 start-page: 397 year: 2013 end-page: 398 article-title: LRRK2 G2385R and LRRK2 R1628P increase risk of Parkinson's disease in a Han Chinese population from Southern Mainland China publication-title: Parkinsonism Relat. Disord. – volume: 5 start-page: e12962 year: 2010 article-title: Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts publication-title: PLoS ONE – volume: 76 start-page: 672 year: 2005 end-page: 680 article-title: Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations publication-title: Am. J. Hum. Genet. – volume: 65 start-page: 738 year: 2005 end-page: 740 article-title: LRRK2 mutations in Parkinson disease publication-title: Neurology – volume: 351 start-page: 1972 year: 2004 end-page: 1977 article-title: Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews publication-title: N. Engl. J. Med. – volume: 235 start-page: 57 year: 1997 end-page: 60 article-title: Identification of Spanish familial Parkinson's disease and screening for the Ala53Thr mutation of the alpha‐synuclein gene in early onset patients publication-title: Neurosci. Lett. – volume: 364 start-page: 1167 year: 2004 end-page: 1169 article-title: Alpha‐synuclein locus duplication as a cause of familial Parkinson's disease publication-title: Lancet – volume: 384 start-page: 327 year: 2005 end-page: 329 article-title: The G2019S LRRK2 mutation is uncommon in an Asian cohort of Parkinson's disease patients publication-title: Neurosci. Lett. – volume: 316 start-page: 570 year: 1987 end-page: 575 article-title: A mutation in the human glucocerebrosidase gene in neuronopathic Gaucher's disease publication-title: N. Engl. J. Med. – volume: 18 start-page: 106 year: 1998 end-page: 108 article-title: Ala30Pro mutation in the gene encoding alpha‐synuclein in Parkinson's disease publication-title: Nat. Genet. – volume: 23 start-page: 90 year: 2003 end-page: 94 article-title: Genotype‐phenotype correlation: familial Parkinson disease publication-title: Neuropathology – volume: 276 start-page: 2045 year: 1997b end-page: 2047 article-title: Mutation in the alpha‐synuclein gene identified in families with Parkinson's disease publication-title: Science – volume: 30 start-page: 770 year: 2015 end-page: 779 article-title: The role of ATP13A2 in Parkinson's disease: clinical phenotypes and molecular mechanisms publication-title: Mov. Disord. – volume: 150B start-page: 1022 year: 2009 end-page: 1023 article-title: LRRK2 G2385R modulates age at onset in Parkinson's disease: a multi‐center pooled analysis publication-title: Am. J. Med. Genet. B Neuropsychiatr. Genet. – volume: 129 start-page: 686 issue: Pt 3 year: 2006 end-page: 694 article-title: Mutational analysis of the PINK1 gene in early‐onset parkinsonism in Europe and North Africa publication-title: Brain – volume: 50 start-page: 293 year: 2001 end-page: 300 article-title: Lewy bodies and parkinsonism in families with parkin mutations publication-title: Ann. Neurol. – volume: 10 start-page: 1649 year: 2001 end-page: 1656 article-title: The importance of gene dosage studies: mutational analysis of the parkin gene in early‐onset parkinsonism publication-title: Hum. Mol. Genet. – volume: 70 start-page: 571 year: 2013 end-page: 579 article-title: Parkin disease: a clinicopathologic entity? publication-title: JAMA Neurol. – volume: 45 start-page: 611 year: 1999 end-page: 617 article-title: Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha‐synuclein/apolipoprotein E genotype publication-title: Ann. Neurol. – volume: 19 start-page: 1146 year: 2004 end-page: 1157 article-title: Distribution, type, and origin of Parkin mutations: review and case studies publication-title: Mov. Disord. – volume: 33 start-page: 1843 year: 2012 article-title: ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor‐Rakeb syndrome publication-title: Neurobiol. Aging – volume: 6 start-page: 171 year: 2005 end-page: 177 article-title: Lrrk2 pathogenic substitutions in Parkinson's disease publication-title: Neurogenetics – ident: e_1_2_4_96_1 doi: 10.1016/j.neuron.2006.10.008 – ident: e_1_2_4_87_1 doi: 10.1002/humu.20436 – ident: e_1_2_4_106_1 doi: 10.1016/j.cub.2005.07.036 – ident: e_1_2_4_165_1 doi: 10.1111/j.1468-1331.2008.02356.x – ident: e_1_2_4_130_1 doi: 10.1056/NEJMc055509 – ident: e_1_2_4_47_1 doi: 10.1038/ng.300 – ident: e_1_2_4_136_1 doi: 10.1136/jnnp.70.5.662 – ident: e_1_2_4_199_1 doi: 10.1212/WNL.0b013e3181f73649 – volume: 10 start-page: 91 year: 1991 ident: e_1_2_4_110_1 article-title: Juvenile parkinsonism: a case with first clinical manifestation at the age of six years and with neuropathological findings suggesting a new pathogenesis publication-title: Clin. Neuropathol. – ident: e_1_2_4_51_1 doi: 10.1371/journal.pone.0012962 – ident: e_1_2_4_70_1 doi: 10.1093/brain/awg142 – ident: e_1_2_4_187_1 doi: 10.1086/319522 – ident: e_1_2_4_78_1 doi: 10.1038/sj.ejhg.5201455 – ident: e_1_2_4_137_1 doi: 10.1091/mbc.3.4.415 – ident: e_1_2_4_99_1 doi: 10.1016/j.bbamcr.2013.07.020 – ident: e_1_2_4_190_1 doi: 10.1097/NEN.0b013e3181efc01c – ident: e_1_2_4_204_1 doi: 10.1016/j.neuron.2004.11.005 – ident: e_1_2_4_95_1 doi: 10.1111/j.1468-1331.2008.02513.x – ident: e_1_2_4_142_1 doi: 10.1212/WNL.48.3.752 – ident: e_1_2_4_109_1 doi: 10.1080/10715760100300831 – ident: e_1_2_4_7_1 doi: 10.1086/302486 – ident: e_1_2_4_114_1 doi: 10.1136/jmg.40.7.543 – ident: e_1_2_4_98_1 doi: 10.2353/ajpath.2008.070823 – ident: e_1_2_4_104_1 doi: 10.1007/s10048-005-0005-1 – ident: e_1_2_4_143_1 doi: 10.1126/science.276.5321.2045 – ident: e_1_2_4_10_1 doi: 10.1073/pnas.1318306111 – ident: e_1_2_4_120_1 doi: 10.1083/jcb.200809125 – ident: e_1_2_4_119_1 doi: 10.1016/S1474-4422(15)00178-7 – ident: e_1_2_4_29_1 doi: 10.1002/mds.25486 – ident: e_1_2_4_85_1 doi: 10.1051/medsci/2006225470 – ident: e_1_2_4_122_1 doi: 10.1016/j.neuron.2009.12.023 – ident: e_1_2_4_172_1 doi: 10.1212/WNL.44.3_Part_1.437 – ident: e_1_2_4_195_1 doi: 10.1016/j.parkreldis.2012.04.013 – ident: e_1_2_4_149_1 doi: 10.1042/BJ20141025 – ident: e_1_2_4_41_1 doi: 10.1212/01.wnl.0000254458.17630.c5 – ident: e_1_2_4_50_1 doi: 10.1016/j.bbrc.2009.08.163 – ident: e_1_2_4_127_1 doi: 10.1002/humu.21277 – ident: e_1_2_4_152_1 doi: 10.1016/S1474-4422(11)70175-2 – ident: e_1_2_4_170_1 doi: 10.1002/ana.67 – ident: e_1_2_4_181_1 doi: 10.1016/S1096-7192(03)00071-4 – ident: e_1_2_4_16_1 doi: 10.1038/nn.3489 – ident: e_1_2_4_131_1 doi: 10.1016/j.neuron.2004.10.023 – ident: e_1_2_4_39_1 doi: 10.1523/JNEUROSCI.1594-04.2004 – ident: e_1_2_4_20_1 doi: 10.1016/S0140-6736(04)17103-1 – ident: e_1_2_4_40_1 doi: 10.1016/j.parkreldis.2012.08.007 – ident: e_1_2_4_191_1 doi: 10.1016/j.parkreldis.2012.05.003 – ident: e_1_2_4_72_1 doi: 10.1111/j.1399-0004.2007.00781.x – ident: e_1_2_4_38_1 doi: 10.1212/01.WNL.0000049470.00180.07 – ident: e_1_2_4_188_1 doi: 10.1126/science.1096284 – ident: e_1_2_4_93_1 doi: 10.1002/mds.23968 – ident: e_1_2_4_133_1 doi: 10.1002/ana.21415 – ident: e_1_2_4_88_1 doi: 10.1136/jmg.2008.062612 – ident: e_1_2_4_171_1 doi: 10.1038/sj.embor.7400074 – ident: e_1_2_4_17_1 doi: 10.1126/science.1195227 – ident: e_1_2_4_48_1 doi: 10.1111/j.1471-4159.2009.06024.x – ident: e_1_2_4_140_1 doi: 10.1002/mds.26243 – ident: e_1_2_4_76_1 doi: 10.1038/33416 – ident: e_1_2_4_14_1 doi: 10.1093/brain/awh676 – ident: e_1_2_4_159_1 doi: 10.1371/journal.pbio.0020362 – ident: e_1_2_4_19_1 doi: 10.1007/s00702-008-0065-0 – ident: e_1_2_4_43_1 doi: 10.1097/WNR.0b013e32801254b6 – ident: e_1_2_4_161_1 doi: 10.1016/j.ajhg.2008.05.005 – ident: e_1_2_4_65_1 doi: 10.1001/archneur.65.4.514 – ident: e_1_2_4_173_1 doi: 10.1016/j.bbrc.2004.05.187 – ident: e_1_2_4_30_1 doi: 10.1001/jamaneurol.2013.172 – ident: e_1_2_4_13_1 doi: 10.1007/s00018-012-1061-y – ident: e_1_2_4_156_1 doi: 10.1007/s100480050083 – ident: e_1_2_4_118_1 doi: 10.1038/ng.3043 – ident: e_1_2_4_56_1 doi: 10.1038/ng.642 – ident: e_1_2_4_58_1 doi: 10.1002/ana.20206 – ident: e_1_2_4_64_1 doi: 10.1001/archneurol.2008.555 – ident: e_1_2_4_117_1 doi: 10.1001/jamaneurol.2013.1925 – ident: e_1_2_4_34_1 doi: 10.1002/ana.10846 – ident: e_1_2_4_108_1 doi: 10.1080/10715760100301381 – ident: e_1_2_4_176_1 doi: 10.1002/mds.21658 – ident: e_1_2_4_91_1 doi: 10.1002/mds.21763 – ident: e_1_2_4_5_1 doi: 10.1093/brain/awv179 – ident: e_1_2_4_67_1 doi: 10.1056/NEJMoa1211103 – ident: e_1_2_4_79_1 doi: 10.1126/science.1109557 – ident: e_1_2_4_62_1 doi: 10.1016/S0140-6736(04)17104-3 – ident: e_1_2_4_169_1 doi: 10.1002/ana.67 – ident: e_1_2_4_167_1 doi: 10.1093/hmg/ddr358 – ident: e_1_2_4_129_1 doi: 10.1038/nn.3350 – ident: e_1_2_4_63_1 doi: 10.1093/brain/awl005 – ident: e_1_2_4_193_1 doi: 10.1093/hmg/11.22.2787 – ident: e_1_2_4_11_1 doi: 10.1007/s10072-003-0108-0 – ident: e_1_2_4_32_1 doi: 10.1002/ana.410430320 – ident: e_1_2_4_116_1 doi: 10.1006/bbrc.1997.6132 – ident: e_1_2_4_139_1 doi: 10.1038/ng.610 – ident: e_1_2_4_101_1 doi: 10.1001/jama.296.6.661 – ident: e_1_2_4_80_1 doi: 10.1093/hmg/ddu099 – ident: e_1_2_4_12_1 doi: 10.1212/01.wnl.0000167546.39375.82 – ident: e_1_2_4_158_1 doi: 10.1083/jcb.142.3.665 – ident: e_1_2_4_94_1 doi: 10.1056/NEJM200005253422103 – ident: e_1_2_4_37_1 doi: 10.1111/tra.12136 – ident: e_1_2_4_111_1 doi: 10.1038/ng1826 – ident: e_1_2_4_31_1 doi: 10.1111/j.1469-1809.2009.00560.x – ident: e_1_2_4_100_1 doi: 10.1086/496902 – ident: e_1_2_4_154_1 doi: 10.1038/ng.485 – ident: e_1_2_4_121_1 doi: 10.1371/journal.pbio.1000298 – ident: e_1_2_4_25_1 doi: 10.1186/1756-6606-2-5 – ident: e_1_2_4_200_1 doi: 10.1002/mds.22514 – ident: e_1_2_4_97_1 doi: 10.1016/j.neuron.2012.11.033 – ident: e_1_2_4_52_1 doi: 10.1016/j.neurobiolaging.2011.12.035 – ident: e_1_2_4_75_1 doi: 10.1016/j.bbrc.2004.03.110 – ident: e_1_2_4_28_1 doi: 10.1212/01.wnl.0000338144.10967.2b – ident: e_1_2_4_73_1 doi: 10.1016/j.parkreldis.2009.10.004 – ident: e_1_2_4_124_1 doi: 10.1002/ana.20753 – ident: e_1_2_4_174_1 doi: 10.1016/j.neulet.2005.04.103 – ident: e_1_2_4_153_1 doi: 10.1002/humu.22075 – ident: e_1_2_4_42_1 doi: 10.1002/ana.10113 – ident: e_1_2_4_182_1 doi: 10.1091/mbc.E09-09-0801 – ident: e_1_2_4_197_1 doi: 10.1093/hmg/ddi134 – ident: e_1_2_4_132_1 doi: 10.1002/humu.20668 – ident: e_1_2_4_126_1 doi: 10.1083/jcb.151.2.297 – ident: e_1_2_4_157_1 doi: 10.1155/2014/690796 – ident: e_1_2_4_24_1 doi: 10.1016/j.parkreldis.2009.11.004 – ident: e_1_2_4_196_1 doi: 10.1016/j.parkreldis.2012.10.019 – ident: e_1_2_4_150_1 doi: 10.1002/ana.21380 – ident: e_1_2_4_205_1 doi: 10.1016/j.ajhg.2011.06.008 – ident: e_1_2_4_22_1 doi: 10.1016/B978-0-12-800149-3.00005-6 – ident: e_1_2_4_35_1 doi: 10.1212/01.WNL.0000169023.51764.b0 – ident: e_1_2_4_179_1 doi: 10.1093/hmg/ddl104 – ident: e_1_2_4_112_1 doi: 10.1046/j.1440-1789.2003.00476.x – ident: e_1_2_4_107_1 doi: 10.1016/j.cub.2005.07.064 – ident: e_1_2_4_203_1 doi: 10.1093/hmg/ddv340 – ident: e_1_2_4_145_1 doi: 10.1136/jnnp.2009.194597 – ident: e_1_2_4_84_1 doi: 10.1001/archneurol.2011.3367 – ident: e_1_2_4_135_1 doi: 10.1007/s00439-008-0582-9 – ident: e_1_2_4_113_1 doi: 10.1212/WNL.0b013e3181ff9685 – ident: e_1_2_4_186_1 doi: 10.1523/JNEUROSCI.5575-11.2012 – ident: e_1_2_4_151_1 doi: 10.1002/ana.21405 – ident: e_1_2_4_146_1 doi: 10.1016/j.parkreldis.2009.06.007 – ident: e_1_2_4_90_1 doi: 10.1212/01.WNL.0000164009.36740.4E – ident: e_1_2_4_183_1 doi: 10.1212/01.wnl.0000338435.78120.0f – ident: e_1_2_4_66_1 doi: 10.1159/000105160 – ident: e_1_2_4_160_1 doi: 10.1038/77060 – ident: e_1_2_4_27_1 doi: 10.1007/s10048-006-0041-5 – ident: e_1_2_4_185_1 doi: 10.1212/01.wnl.0000327607.28928.e6 – ident: e_1_2_4_138_1 doi: 10.1523/JNEUROSCI.3799-09.2009 – ident: e_1_2_4_49_1 doi: 10.1042/BST20120054 – ident: e_1_2_4_77_1 doi: 10.1038/ncpneuro0126 – ident: e_1_2_4_36_1 doi: 10.1016/j.parkreldis.2006.12.001 – ident: e_1_2_4_198_1 doi: 10.1038/ng.608 – ident: e_1_2_4_18_1 doi: 10.1073/pnas.0402959101 – ident: e_1_2_4_57_1 doi: 10.1016/S1353-8020(09)70815-6 – ident: e_1_2_4_166_1 doi: 10.1016/S0140-6736(04)17117-1 – ident: e_1_2_4_162_1 doi: 10.1212/WNL.0b013e3181b28601 – ident: e_1_2_4_53_1 doi: 10.1056/NEJMoa1211851 – ident: e_1_2_4_2_1 doi: 10.1002/mds.23265 – ident: e_1_2_4_45_1 doi: 10.1002/ana.23614 – ident: e_1_2_4_175_1 doi: 10.1007/s00439-006-0268-0 – ident: e_1_2_4_177_1 doi: 10.1002/ajmg.b.30923 – ident: e_1_2_4_184_1 doi: 10.1056/NEJM198703053161002 – ident: e_1_2_4_128_1 doi: 10.1212/WNL.0b013e31828727d4 – ident: e_1_2_4_74_1 doi: 10.1093/brain/awv132 – ident: e_1_2_4_147_1 doi: 10.1038/ng1884 – ident: e_1_2_4_164_1 doi: 10.1038/ejhg.2010.254 – ident: e_1_2_4_141_1 doi: 10.1093/brain/awg136 – ident: e_1_2_4_9_1 doi: 10.1016/j.parkreldis.2010.11.008 – ident: e_1_2_4_55_1 doi: 10.1091/mbc.11.12.4105 – ident: e_1_2_4_23_1 doi: 10.1093/hmg/ddq469 – ident: e_1_2_4_105_1 doi: 10.1016/j.cell.2011.06.001 – ident: e_1_2_4_6_1 doi: 10.1111/j.1365-2990.2007.00888.x – ident: e_1_2_4_59_1 doi: 10.1016/S1474-4422(08)70117-0 – ident: e_1_2_4_180_1 doi: 10.1006/mgme.2001.3201 – ident: e_1_2_4_102_1 doi: 10.1002/humu.9472 – ident: e_1_2_4_192_1 doi: 10.1212/WNL.56.4.555 – ident: e_1_2_4_68_1 doi: 10.1086/429256 – ident: e_1_2_4_61_1 doi: 10.1002/mds.20234 – ident: e_1_2_4_178_1 doi: 10.1002/humu.21225 – ident: e_1_2_4_148_1 doi: 10.1016/S0168-9525(01)02410-6 – ident: e_1_2_4_92_1 doi: 10.1016/j.bbadis.2009.09.010 – ident: e_1_2_4_103_1 doi: 10.1371/journal.pbio.0020327 – ident: e_1_2_4_3_1 doi: 10.1002/ana.10675 – ident: e_1_2_4_8_1 doi: 10.1016/j.cellsig.2005.03.002 – ident: e_1_2_4_89_1 doi: 10.1212/WNL.0b013e318253d5f2 – ident: e_1_2_4_82_1 doi: 10.1002/1531-8249(199905)45:5<611::AID-ANA9>3.0.CO;2-X – ident: e_1_2_4_26_1 doi: 10.1073/pnas.1112368109 – ident: e_1_2_4_60_1 doi: 10.1093/hmg/10.16.1649 – ident: e_1_2_4_155_1 doi: 10.1126/science.277.5324.387 – ident: e_1_2_4_202_1 doi: 10.1016/j.jmb.2005.12.030 – ident: e_1_2_4_54_1 doi: 10.1016/j.nbd.2011.12.015 – ident: e_1_2_4_15_1 doi: 10.1001/archneurol.2010.281 – ident: e_1_2_4_115_1 doi: 10.1016/S0304-3940(97)00710-6 – ident: e_1_2_4_21_1 doi: 10.1007/s10048-008-0138-0 – ident: e_1_2_4_33_1 doi: 10.1002/ana.1132 – ident: e_1_2_4_44_1 doi: 10.1016/S1474-4422(06)70578-6 – ident: e_1_2_4_144_1 doi: 10.1093/hmg/11.20.2417 – ident: e_1_2_4_168_1 doi: 10.1126/science.1090278 – ident: e_1_2_4_86_1 doi: 10.1056/NEJMc055540 – ident: e_1_2_4_83_1 doi: 10.1055/s-0031-1299782 – ident: e_1_2_4_163_1 doi: 10.1038/ng.487 – ident: e_1_2_4_123_1 doi: 10.1042/BJ20100483 – ident: e_1_2_4_4_1 doi: 10.1056/NEJMoa033277 – ident: e_1_2_4_194_1 doi: 10.1073/pnas.1100976108 – ident: e_1_2_4_201_1 doi: 10.1002/ana.10795 – ident: e_1_2_4_134_1 doi: 10.1016/j.neulet.2006.09.003 – ident: e_1_2_4_69_1 doi: 10.1083/jcb.201402104 – ident: e_1_2_4_125_1 doi: 10.1111/j.1471-4159.2012.07809.x – ident: e_1_2_4_71_1 doi: 10.1093/brain/awh667 – ident: e_1_2_4_46_1 doi: 10.1073/pnas.0710685105 – ident: e_1_2_4_189_1 doi: 10.1016/j.ajhg.2011.06.001 – ident: e_1_2_4_81_1 doi: 10.1038/ng0298-106 |
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| Snippet | Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of those older than 75 years of age. Clinically, Parkinson's disease (PD)... Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of those older than 75 years of age. Clinically, Parkinson's disease (PD)... |
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| SubjectTerms | alpha-Synuclein - genetics Animals genetics Genome-Wide Association Study - methods Humans mendelian Mutation - genetics Parkinson Disease - diagnosis Parkinson Disease - genetics Parkinsons Disease risk alleles Ubiquitin-Protein Ligases - genetics |
| Title | Genetics in Parkinson disease: Mendelian versus non‐Mendelian inheritance |
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