Surface Characteristics, Copper Release, and Toxicity of Nano- and Micrometer-Sized Copper and Copper(II) Oxide Particles: A Cross-Disciplinary Study

An interdisciplinary and multianalytical research effort is undertaken to assess the toxic aspects of thoroughly characterized nano‐ and micrometer‐sized particles of oxidized metallic copper and copper(II) oxide in contact with cultivated lung cells, as well as copper release in relevant media. All...

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Published in:	Small (Weinheim an der Bergstrasse, Germany) Vol. 5; no. 3; pp. 389 - 399
Main Authors:	Midander, Klara, Cronholm, Pontus, Karlsson, Hanna L., Elihn, Karine, Möller, Lennart, Leygraf, Christofer, Wallinder, Inger Odnevall
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 06.02.2009 WILEY‐VCH Verlag
Subjects:	Cell Line Chemical engineering Chemical process and manufacturing engineering copper Copper - chemistry Copper - toxicity cytotoxicity DNA Damage Kemisk process- och produktionsteknik Kemiteknik Metal Nanoparticles - chemistry Metal Nanoparticles - toxicity Metal Nanoparticles - ultrastructure Microscopy, Electron, Scanning nanoparticles particle characterization Spectrophotometry, Atomic Surface and colloid chemistry Surface Properties TECHNOLOGY TEKNIKVETENSKAP Yt- och kolloidkemi copper particle characterization nanoparticles DNA damage cytotoxicity
ISSN:	1613-6810, 1613-6829, 1613-6829
Online Access:	Get full text
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Abstract	An interdisciplinary and multianalytical research effort is undertaken to assess the toxic aspects of thoroughly characterized nano‐ and micrometer‐sized particles of oxidized metallic copper and copper(II) oxide in contact with cultivated lung cells, as well as copper release in relevant media. All particles, except micrometer‐sized Cu, release more copper in serum‐containing cell medium (supplemented Dulbecco's minimal essential medium) compared to identical exposures in phosphate‐buffered saline. Sonication of particles for dispersion prior to exposure has a large effect on the initial copper release from Cu nanoparticles. A clear size‐dependent effect is observed from both a copper release and a toxicity perspective. In agreement with greater released amounts of copper per quantity of particles from the nanometer‐sized particles compared to the micrometer‐sized particles, the nanometer particles cause a higher degree of DNA damage (single‐strand breaks) and cause a significantly higher percentage of cell death compared to cytotoxicity induced by micrometer‐sized particles. Cytotoxic effects related to the released copper fraction are found to be significantly lower than the effects related to particles. No DNA damage is induced by the released copper fraction. Save your breath: A multianalytical approach is used to assess the toxicity to cultured lung cells of micro‐ and nanoparticles of oxidized Cu and CuO in relation to the particle characteristics (see picture). Larger amounts of copper per quantity of particles are released from nanoparticles than micrometer‐sized particles. The cytotoxic effects of nanoparticles are caused by the particles rather than the released copper fraction.
AbstractList	An interdisciplinary and multianalytical research effort is undertaken to assess the toxic aspects of thoroughly characterized nano- and micrometer-sized particles of oxidized metallic copper and copper(II) oxide in contact with cultivated lung cells, as well as copper release in relevant media. All particles, except micrometer-sized Cu, release more copper in serum-containing cell medium (supplemented Dulbecco's minimal essential medium) compared to identical exposures in phosphate-buffered saline. Sonication of particles for dispersion prior to exposure has a large effect on the initial copper release from Cu nanoparticles. A clear size-dependent effect is observed from both a copper release and a toxicity perspective. In agreement with greater released amounts of copper per quantity of particles from the nanometer-sized particles compared to the micrometer-sized particles, the nanometer particles cause a higher degree of DNA damage (single-strand breaks) and cause a significantly higher percentage of cell death compared to cytotoxicity induced by micrometer-sized particles. Cytotoxic effects related to the released copper fraction are found to be significantly lower than the effects related to particles. No DNA damage is induced by the released copper fraction.An interdisciplinary and multianalytical research effort is undertaken to assess the toxic aspects of thoroughly characterized nano- and micrometer-sized particles of oxidized metallic copper and copper(II) oxide in contact with cultivated lung cells, as well as copper release in relevant media. All particles, except micrometer-sized Cu, release more copper in serum-containing cell medium (supplemented Dulbecco's minimal essential medium) compared to identical exposures in phosphate-buffered saline. Sonication of particles for dispersion prior to exposure has a large effect on the initial copper release from Cu nanoparticles. A clear size-dependent effect is observed from both a copper release and a toxicity perspective. In agreement with greater released amounts of copper per quantity of particles from the nanometer-sized particles compared to the micrometer-sized particles, the nanometer particles cause a higher degree of DNA damage (single-strand breaks) and cause a significantly higher percentage of cell death compared to cytotoxicity induced by micrometer-sized particles. Cytotoxic effects related to the released copper fraction are found to be significantly lower than the effects related to particles. No DNA damage is induced by the released copper fraction. An interdisciplinary and multianalytical research effort is undertaken to assess the toxic aspects of thoroughly characterized nano‐ and micrometer‐sized particles of oxidized metallic copper and copper(II) oxide in contact with cultivated lung cells, as well as copper release in relevant media. All particles, except micrometer‐sized Cu, release more copper in serum‐containing cell medium (supplemented Dulbecco's minimal essential medium) compared to identical exposures in phosphate‐buffered saline. Sonication of particles for dispersion prior to exposure has a large effect on the initial copper release from Cu nanoparticles. A clear size‐dependent effect is observed from both a copper release and a toxicity perspective. In agreement with greater released amounts of copper per quantity of particles from the nanometer‐sized particles compared to the micrometer‐sized particles, the nanometer particles cause a higher degree of DNA damage (single‐strand breaks) and cause a significantly higher percentage of cell death compared to cytotoxicity induced by micrometer‐sized particles. Cytotoxic effects related to the released copper fraction are found to be significantly lower than the effects related to particles. No DNA damage is induced by the released copper fraction. Save your breath: A multianalytical approach is used to assess the toxicity to cultured lung cells of micro‐ and nanoparticles of oxidized Cu and CuO in relation to the particle characteristics (see picture). Larger amounts of copper per quantity of particles are released from nanoparticles than micrometer‐sized particles. The cytotoxic effects of nanoparticles are caused by the particles rather than the released copper fraction. An interdisciplinary and multianalytical research effort is undertaken to assess the toxic aspects of thoroughly characterized nano- and micrometer-sized particles of oxidized metallic copper and copper(II) oxide in contact with cultivated lung cells, as well as copper release in relevant media. All particles, except micrometer-sized Cu, release more copper in serum-containing cell medium (supplemented Dulbecco's minimal essential medium) compared to identical exposures in phosphate-buffered saline. Sonication of particles for dispersion prior to exposure has a large effect on the initial copper release from Cu nanoparticles. A clear size-dependent effect is observed from both a copper release and a toxicity perspective. In agreement with greater released amounts of copper per quantity of particles from the nanometer-sized particles compared to the micrometer-sized particles, the nanometer particles cause a higher degree of DNA damage (single-strand breaks) and cause a significantly higher percentage of cell death compared to cytotoxicity induced by micrometer-sized particles. Cytotoxic effects related to the released copper fraction are found to be significantly lower than the effects related to particles. No DNA damage is induced by the released copper fraction.
Author	Elihn, Karine Cronholm, Pontus Möller, Lennart Wallinder, Inger Odnevall Leygraf, Christofer Karlsson, Hanna L. Midander, Klara
Author_xml	– sequence: 1 givenname: Klara surname: Midander fullname: Midander, Klara organization: Division of Corrosion Science, Department of Chemistry School of Chemical Science and Engineering Royal Institute of Technology Drottning Kristinas väg 51, 100 44 Stockholm (Sweden) – sequence: 2 givenname: Pontus surname: Cronholm fullname: Cronholm, Pontus organization: Unit for Analytical Toxicology, Department of Biosciences at Novum Karolinska Institutet, 141 57 Huddinge, Stockholm (Sweden) – sequence: 3 givenname: Hanna L. surname: Karlsson fullname: Karlsson, Hanna L. organization: Unit for Analytical Toxicology, Department of Biosciences at Novum Karolinska Institutet, 141 57 Huddinge, Stockholm (Sweden) – sequence: 4 givenname: Karine surname: Elihn fullname: Elihn, Karine organization: Atmospheric Science Unit Department of Applied Environmental Science Stockholm University, 106 91 Stockholm (Sweden) – sequence: 5 givenname: Lennart surname: Möller fullname: Möller, Lennart organization: Unit for Analytical Toxicology, Department of Biosciences at Novum Karolinska Institutet, 141 57 Huddinge, Stockholm (Sweden) – sequence: 6 givenname: Christofer surname: Leygraf fullname: Leygraf, Christofer organization: Division of Corrosion Science, Department of Chemistry School of Chemical Science and Engineering Royal Institute of Technology Drottning Kristinas väg 51, 100 44 Stockholm (Sweden) – sequence: 7 givenname: Inger Odnevall surname: Wallinder fullname: Wallinder, Inger Odnevall email: ingero@kth.se organization: Division of Corrosion Science, Department of Chemistry School of Chemical Science and Engineering Royal Institute of Technology Drottning Kristinas väg 51, 100 44 Stockholm (Sweden)
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/19148889$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-11691$$DView record from Swedish Publication Index (Kungliga Tekniska Högskolan) http://kipublications.ki.se/Default.aspx?queryparsed=id:118344816$$DView record from Swedish Publication Index (Karolinska Institutet)
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SubjectTerms	Cell Line Chemical engineering Chemical process and manufacturing engineering copper Copper - chemistry Copper - toxicity cytotoxicity DNA Damage Kemisk process- och produktionsteknik Kemiteknik Metal Nanoparticles - chemistry Metal Nanoparticles - toxicity Metal Nanoparticles - ultrastructure Microscopy, Electron, Scanning nanoparticles particle characterization Spectrophotometry, Atomic Surface and colloid chemistry Surface Properties TECHNOLOGY TEKNIKVETENSKAP Yt- och kolloidkemi
Title	Surface Characteristics, Copper Release, and Toxicity of Nano- and Micrometer-Sized Copper and Copper(II) Oxide Particles: A Cross-Disciplinary Study
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