Hemostatic properties and the role of cell receptor recognition in human hair keratin protein hydrogels

Driven by new discoveries in stem-cell biology and regenerative medicine, there is broad interest in biomaterials that go beyond basic interactions with cells and tissues to actively direct and sustain cellular behavior. Keratin biomaterials have the potential to achieve these goals but have been in...

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Veröffentlicht in:	Biomaterials Jg. 34; H. 11; S. 2632 - 2640
Hauptverfasser:	Burnett, Luke R., Rahmany, Maria B., Richter, Jillian R., Aboushwareb, Tamer A., Eberli, Daniel, Ward, Catherine L., Orlando, Giuseppe, Hantgan, Roy R., Van Dyke, Mark E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier Ltd 01.04.2013
Schlagworte:	Adhesion Advanced Basic Science Animals biocompatible materials Biocompatible Materials - analysis Biocompatible Materials - chemistry Biomaterial biotechnology Blood Platelets - cytology Blood Platelets - metabolism Blotting, Western Cell Adhesion Colorimetry crosslinking Dentistry drugs Electrophoresis Hair - chemistry Hemostasis Hemostatics - metabolism Humans hydrocolloids Hydrogels - analysis Hydrogels - chemistry Integrin Keratin Keratins - analysis Keratins - chemistry liver Mass Spectrometry medicine Microscopy, Confocal Microscopy, Electron, Scanning Platelet Regenerative Medicine - methods Rheology Swine tissue engineering Tissue Engineering - methods tissues Keratin Platelet Biomaterial Integrin Hemostasis Adhesion
ISSN:	0142-9612, 1878-5905, 1878-5905
Online-Zugang:	Volltext
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Abstract	Driven by new discoveries in stem-cell biology and regenerative medicine, there is broad interest in biomaterials that go beyond basic interactions with cells and tissues to actively direct and sustain cellular behavior. Keratin biomaterials have the potential to achieve these goals but have been inadequately described in terms of composition, structure, and cell-instructive characteristics. In this manuscript we describe and characterize a keratin-based biomaterial, demonstrate self-assembly of cross-linked hydrogels, investigate a cell-specific interaction that is dependent on the hydrogel structure and mediated by specific biomaterial–receptor interactions, and show one potential medical application that relies on receptor binding - the ability to achieve hemostasis in a lethal liver injury model. Keratin biomaterials represent a significant advance in biotechnology as they combine the compatibility of natural materials with the chemical flexibility of synthetic materials. These characteristics allow for a system that can be formulated into several varieties of cell-instructive biomaterials with potential uses in tissue engineering, regenerative medicine, drug and cell delivery, and trauma.
AbstractList	Driven by new discoveries in stem-cell biology and regenerative medicine, there is broad interest in biomaterials that go beyond basic interactions with cells and tissues to actively direct and sustain cellular behavior. Keratin biomaterials have the potential to achieve these goals but have been inadequately described in terms of composition, structure, and cell-instructive characteristics. In this manuscript we describe and characterize a keratin-based biomaterial, demonstrate self-assembly of cross-linked hydrogels, investigate a cell-specific interaction that is dependent on the hydrogel structure and mediated by specific biomaterial-receptor interactions, and show one potential medical application that relies on receptor binding - the ability to achieve hemostasis in a lethal liver injury model. Keratin biomaterials represent a significant advance in biotechnology as they combine the compatibility of natural materials with the chemical flexibility of synthetic materials. These characteristics allow for a system that can be formulated into several varieties of cell-instructive biomaterials with potential uses in tissue engineering, regenerative medicine, drug and cell delivery, and trauma. Driven by new discoveries in stem-cell biology and regenerative medicine, there is broad interest in biomaterials that go beyond basic interactions with cells and tissues to actively direct and sustain cellular behavior. Keratin biomaterials have the potential to achieve these goals but have been inadequately described in terms of composition, structure, and cell-instructive characteristics. In this manuscript we describe and characterize a keratin-based biomaterial, demonstrate self-assembly of cross-linked hydrogels, investigate a cell-specific interaction that is dependent on the hydrogel structure and mediated by specific biomaterial-receptor interactions, and show one potential medical application that relies on receptor binding - the ability to achieve hemostasis in a lethal liver injury model. Keratin biomaterials represent a significant advance in biotechnology as they combine the compatibility of natural materials with the chemical flexibility of synthetic materials. These characteristics allow for a system that can be formulated into several varieties of cell-instructive biomaterials with potential uses in tissue engineering, regenerative medicine, drug and cell delivery, and trauma.Driven by new discoveries in stem-cell biology and regenerative medicine, there is broad interest in biomaterials that go beyond basic interactions with cells and tissues to actively direct and sustain cellular behavior. Keratin biomaterials have the potential to achieve these goals but have been inadequately described in terms of composition, structure, and cell-instructive characteristics. In this manuscript we describe and characterize a keratin-based biomaterial, demonstrate self-assembly of cross-linked hydrogels, investigate a cell-specific interaction that is dependent on the hydrogel structure and mediated by specific biomaterial-receptor interactions, and show one potential medical application that relies on receptor binding - the ability to achieve hemostasis in a lethal liver injury model. Keratin biomaterials represent a significant advance in biotechnology as they combine the compatibility of natural materials with the chemical flexibility of synthetic materials. These characteristics allow for a system that can be formulated into several varieties of cell-instructive biomaterials with potential uses in tissue engineering, regenerative medicine, drug and cell delivery, and trauma. Abstract Driven by new discoveries in stem-cell biology and regenerative medicine, there is broad interest in biomaterials that go beyond basic interactions with cells and tissues to actively direct and sustain cellular behavior. Keratin biomaterials have the potential to achieve these goals but have been inadequately described in terms of composition, structure, and cell-instructive characteristics. In this manuscript we describe and characterize a keratin-based biomaterial, demonstrate self-assembly of cross-linked hydrogels, investigate a cell-specific interaction that is dependent on the hydrogel structure and mediated by specific biomaterial–receptor interactions, and show one potential medical application that relies on receptor binding - the ability to achieve hemostasis in a lethal liver injury model. Keratin biomaterials represent a significant advance in biotechnology as they combine the compatibility of natural materials with the chemical flexibility of synthetic materials. These characteristics allow for a system that can be formulated into several varieties of cell-instructive biomaterials with potential uses in tissue engineering, regenerative medicine, drug and cell delivery, and trauma.
Author	Eberli, Daniel Burnett, Luke R. Rahmany, Maria B. Aboushwareb, Tamer A. Ward, Catherine L. Orlando, Giuseppe Richter, Jillian R. Van Dyke, Mark E. Hantgan, Roy R.
Author_xml	– sequence: 1 givenname: Luke R. surname: Burnett fullname: Burnett, Luke R. email: lburnett@wakehealth.edu organization: KeraNetics LLC, Winston Salem, NC, USA – sequence: 2 givenname: Maria B. surname: Rahmany fullname: Rahmany, Maria B. email: mbahawdo@wakehealth.edu organization: Department of Orthopaedic Surgery, Wake Forest University School of Medicine, USA – sequence: 3 givenname: Jillian R. surname: Richter fullname: Richter, Jillian R. email: jrichter@wakehealth.edu organization: Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, USA – sequence: 4 givenname: Tamer A. surname: Aboushwareb fullname: Aboushwareb, Tamer A. email: aboushwareb_tamer@allergan.com organization: Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, USA – sequence: 5 givenname: Daniel surname: Eberli fullname: Eberli, Daniel email: daniel.eberli@usz.ch organization: Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, USA – sequence: 6 givenname: Catherine L. surname: Ward fullname: Ward, Catherine L. email: catward@wakehealth.edu organization: Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, USA – sequence: 7 givenname: Giuseppe surname: Orlando fullname: Orlando, Giuseppe email: gorlando@wakehealth.edu organization: Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, USA – sequence: 8 givenname: Roy R. surname: Hantgan fullname: Hantgan, Roy R. email: rhantgan@wakehealth.edu organization: Department of Biochemistry, Wake Forest School of Medicine, USA – sequence: 9 givenname: Mark E. surname: Van Dyke fullname: Van Dyke, Mark E. email: mavandyk@wakehealth.edu, mvandyk5@vt.edu organization: Department of Orthopaedic Surgery, Wake Forest University School of Medicine, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/23340195$$D View this record in MEDLINE/PubMed
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Snippet	Driven by new discoveries in stem-cell biology and regenerative medicine, there is broad interest in biomaterials that go beyond basic interactions with cells... Abstract Driven by new discoveries in stem-cell biology and regenerative medicine, there is broad interest in biomaterials that go beyond basic interactions...
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SubjectTerms	Adhesion Advanced Basic Science Animals biocompatible materials Biocompatible Materials - analysis Biocompatible Materials - chemistry Biomaterial biotechnology Blood Platelets - cytology Blood Platelets - metabolism Blotting, Western Cell Adhesion Colorimetry crosslinking Dentistry drugs Electrophoresis Hair - chemistry Hemostasis Hemostatics - metabolism Humans hydrocolloids Hydrogels - analysis Hydrogels - chemistry Integrin Keratin Keratins - analysis Keratins - chemistry liver Mass Spectrometry medicine Microscopy, Confocal Microscopy, Electron, Scanning Platelet Regenerative Medicine - methods Rheology Swine tissue engineering Tissue Engineering - methods tissues
Title	Hemostatic properties and the role of cell receptor recognition in human hair keratin protein hydrogels
URI	https://www.clinicalkey.com/#!/content/1-s2.0-S0142961212014020 https://www.clinicalkey.es/playcontent/1-s2.0-S0142961212014020 https://dx.doi.org/10.1016/j.biomaterials.2012.12.022 https://www.ncbi.nlm.nih.gov/pubmed/23340195 https://www.proquest.com/docview/1284289935 https://www.proquest.com/docview/1710231978
Volume	34
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