A review of dietary and non-dietary exposure to bisphenol-A

► Food and non-food sources of BPA are reviewed. ► Overall exposure to BPA is dominated by food sources. ► Overall exposure to BPA can be reliably estimated by human biomonitoring of urine. ► Alternatives for polycarbonate should be thoroughly toxicologically tested. Due to the large number of appli...

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Vydáno v:Food and chemical toxicology Ročník 50; číslo 10; s. 3725 - 3740
Hlavní autoři: Geens, Tinne, Aerts, Dominique, Berthot, Carl, Bourguignon, Jean-Pierre, Goeyens, Leo, Lecomte, Philippe, Maghuin-Rogister, Guy, Pironnet, Anne-Madeleine, Pussemier, Luc, Scippo, Marie-Louise, Van Loco, Joris, Covaci, Adrian
Médium: Journal Article
Jazyk:angličtina
Vydáno: Oxford Elsevier Ltd 01.10.2012
Elsevier
Témata:
acceptable daily intake
Alternatives
Benzhydryl Compounds - chemistry
Benzhydryl Compounds - toxicity
Biological and medical sciences
Bisphenol-A
dental materials
Endocrinologie, métabolisme & nutrition
Endocrinology, metabolism & nutrition
Environmental Exposure
Environmental Pollutants - chemistry
Environmental Pollutants - toxicity
Environmental sciences & ecology
epoxides
exposure assessment
exposure pathways
Food Contamination
Food sources
Human exposure
Human health sciences
Humans
Life sciences
medical equipment
Medical sciences
Non-food sources
paperboard
Phenols - chemistry
Phenols - toxicity
poly(vinyl chloride)
resins
Review
Sciences de la santé humaine
Sciences de l’environnement & écologie
Sciences du vivant
Toxicology
Review
Bisphenol-A
Food sources
Alternatives
Non-food sources
Human exposure
Human
Nutrition
Endocrine disruptor
Exposure
Chemical product
Bisphenol A
Diet
Pollution source
Phenols
Bibliographic review
Organic compounds
Food
ISSN:0278-6915, 1873-6351, 1873-6351
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Shrnutí:► Food and non-food sources of BPA are reviewed. ► Overall exposure to BPA is dominated by food sources. ► Overall exposure to BPA can be reliably estimated by human biomonitoring of urine. ► Alternatives for polycarbonate should be thoroughly toxicologically tested. Due to the large number of applications of bisphenol-A (BPA), the human exposure routes are multiple. We aimed to review shortly the food and non-food sources of BPA, and to evaluate their contribution to the human exposure. Food sources discussed here include epoxy resins, polycarbonate and other applications, such as paperboard and polyvinylchloride materials. Among the non-food sources, exposures through dust, thermal paper, dental materials, and medical devices were summarized. Based on the available data for these exposure sources, it was concluded that the exposure to BPA from non-food sources is generally lower than that from exposure from food by at least one order of magnitude for most studied subgroups. The use of urinary concentrations from biomonitoring studies was evaluated and the back-calculation of BPA intake seems reliable for the overall exposure assessment. In general, the total exposure to BPA is several orders of magnitude lower than the current tolerable daily intake of 50μg/kgbw/day. Finally, the paper concludes with some critical remarks and recommendations on future human exposure studies to BPA.
Bibliografie:http://dx.doi.org/10.1016/j.fct.2012.07.059
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
scopus-id:2-s2.0-84865465012
ISSN:0278-6915
1873-6351
1873-6351
DOI:10.1016/j.fct.2012.07.059