Mutation spectrum of NOD2 reveals recessive inheritance as a main driver of Early Onset Crohn’s Disease

Inflammatory bowel disease (IBD), clinically defined as Crohn’s disease (CD), ulcerative colitis (UC), or IBD-unclassified, results in chronic inflammation of the gastrointestinal tract in genetically susceptible hosts. Pediatric onset IBD represents ≥ 25% of all IBD diagnoses and often presents wit...

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Bibliographic Details
Published in:	Scientific reports Vol. 11; no. 1; pp. 5595 - 10
Main Authors:	Horowitz, Julie E., Warner, Neil, Staples, Jeffrey, Crowley, Eileen, Gosalia, Nehal, Murchie, Ryan, Van Hout, Cristopher, Fiedler, Karoline, Welch, Gabriel, King, Alejandra Klauer, Reid, Jeffrey G., Overton, John D., Baras, Aris, Shuldiner, Alan R., Griffiths, Anne, Gottesman, Omri, Muise, Aleixo M., Gonzaga-Jauregui, Claudia
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 10.03.2021 Nature Publishing Group Nature Portfolio
Subjects:	631/208/212/2301 631/208/248 631/208/514 Alleles Crohn's disease Gastrointestinal tract Heredity Humanities and Social Sciences Inflammatory bowel disease Inflammatory bowel diseases Intestine multidisciplinary NOD2 protein Patients Pediatrics Population genetics Science Science (multidisciplinary) Ulcerative colitis
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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