Clinical validation of a next-generation sequencing-based multi-cancer early detection “liquid biopsy” blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study

Cancer is the leading cause of death in dogs, yet there are no established screening paradigms for early detection. Liquid biopsy methods that interrogate cancer-derived genomic alterations in cell-free DNA in blood are being adopted for multi-cancer early detection in human medicine and are now ava...

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Bibliographic Details
Published in:	PloS one Vol. 17; no. 4; p. e0266623
Main Authors:	Flory, Andi, Kruglyak, Kristina M., Tynan, John A., McLennan, Lisa M., Rafalko, Jill M., Fiaux, Patrick Christian, Hernandez, Gilberto E., Marass, Francesco, Nakashe, Prachi, Ruiz-Perez, Carlos A., Fath, Donna M., Jennings, Thuy, Motalli-Pepio, Rita, Wotrang, Kate, McCleary-Wheeler, Angela L., Lana, Susan, Phillips, Brenda, Flesner, Brian K., Leibman, Nicole F., LaDue, Tracy, Tripp, Chelsea D., Coomber, Brenda L., Woods, J. Paul, Miller, Mairin, Aiken, Sean W., Wolf-Ringwall, Amber, Borgatti, Antonella, Kraska, Kathleen, Thomson, Christopher B., Kosanovich Cahalane, Alane, Murray, Rebecca L., Kisseberth, William C., Camps-Palau, Maria A., Floch, Franck, Beaudu-Lange, Claire, Klajer-Peres, Aurélia, Keravel, Olivier, Fribourg-Blanc, Luc-André, Mazetier, Pascale Chicha, Marco, Angelo, McLeod, Molly B., Portillo, Erin, Clark, Terry S., Judd, Scott, Feinberg, C. Kirk, Benitez, Marie, Runyan, Candace, Hackett, Lindsey, Lafey, Scott, Richardson, Danielle, Vineyard, Sarah, Tefend Campbell, Mary, Dharajiya, Nilesh, Jensen, Taylor J., van den Boom, Dirk, Diaz, Luis A., Grosu, Daniel S., Polk, Arthur, Marsal, Kalle, Hicks, Susan Cho, Lytle, Katherine M., Holtvoigt, Lauren, Chibuk, Jason, Chorny, Ilya, Tsui, Dana W. Y.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 26.04.2022 Public Library of Science (PLoS)
Subjects:	Adenocarcinoma Advisors Animals Biology and Life Sciences Biomarkers, Tumor - genetics Biomedical materials Biopsy Blood Blood tests Bone cancer Breast cancer Cancer Deoxyribonucleic acid Diagnosis DNA DNA sequencing Dogs Early Detection of Cancer Gene sequencing Governors Hemangiosarcoma Hematologic Tests High-Throughput Nucleotide Sequencing - methods Hospitals Humans Liquid Biopsy Lymphoma Mammary gland Mammary glands Medical diagnosis Medical examination Medicine and Health Sciences Melanoma Next-generation sequencing Osteosarcoma Patients Prostate cancer Sarcoma Skin cancer Soft tissue sarcoma Soft tissues Tumors Veterinary colleges Veterinary medicine Veterinary services United States New York United States > US Minnesota California Guelph Ontario Canada La Jolla California Canada Colorado China Paris France Missouri Hong Kong China Ohio France
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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