Mitochondrial SLC25 Carriers: Novel Targets for Cancer Therapy

The transfer of metabolites through the mitochondrial membranes is a vital process that is highly controlled and regulated by the inner membrane. A variety of metabolites, nucleotides, and cofactors are transported across the inner mitochondrial membrane (IMM) by a superfamily of membrane transporte...

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Vydáno v:Molecules (Basel, Switzerland) Ročník 25; číslo 10; s. 2417
Hlavní autoři: Rochette, Luc, Meloux, Alexandre, Zeller, Marianne, Malka, Gabriel, Cottin, Yves, Vergely, Catherine
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 22.05.2020
MDPI
Témata:
Adenosine triphosphate
Amino acids
Biochemistry, Molecular Biology
Bioenergetics
Biological Transport - genetics
Cancer
Copper
Genes
Homeostasis
Humans
Life Sciences
Mammals
Metabolism
Metabolites
Mitochondria
Mitochondria - genetics
Mitochondria - metabolism
Mitochondrial DNA
Mitochondrial Membrane Transport Proteins - genetics
Mitochondrial Proteins - antagonists & inhibitors
Mitochondrial Proteins - genetics
Multigene Family - genetics
Mutation
Neoplasms - genetics
Neoplasms - therapy
Organic Anion Transporters - antagonists & inhibitors
Organic Anion Transporters - genetics
phosphate carrier
Phosphorylation
protein family
Proteins
Review
SLC25
SLC25
phosphate carrier
protein family
mitochondria
ISSN:1420-3049, 1420-3049
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Shrnutí:The transfer of metabolites through the mitochondrial membranes is a vital process that is highly controlled and regulated by the inner membrane. A variety of metabolites, nucleotides, and cofactors are transported across the inner mitochondrial membrane (IMM) by a superfamily of membrane transporters which are known as the mitochondrial carrier family (MCF) or the solute carrier family 25 (SLC25 protein family). In humans, the MCF has 53 members encoded by nuclear genes. Members of the SLC25 family of transporters, which is the largest group of solute carriers, are also known as mitochondrial carriers (MCs). Because MCs are nuclear-coded proteins, they must be imported into the IMM. When compared with normal cells, the mitochondria of cancer cells exhibit significantly increased transmembrane potentials and a number of their transporters are altered. SLC25 members were identified as potential biomarkers for various cancers. The objective of this review is to summarize what is currently known about the involvement of mitochondrial SLC25 carriers in associated diseases. This review suggests that the SLC25 family could be used for the development of novel points of attack for targeted cancer therapy.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25102417