Vitreous Substitutes : The Present and the Future

Vitreoretinal surgery has advanced in numerous directions during recent years. The removal of the vitreous body is one of the main characteristics of this surgical procedure. Several molecules have been tested in the past to fill the vitreous cavity and to mimic its functions. We here review the cur...

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Vydáno v:BioMed research international Ročník 2014; číslo 2014; s. 1 - 12
Hlavní autoři: Donati, Simone, Caprani, Simona Maria, Airaghi, Giulia, Vinciguerra, Riccardo, Bartalena, Luigi, Testa, Francesco, Mariotti, Cesare, Porta, Giovanni, Simonelli, Francesca, Azzolini, Claudio
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cairo, Egypt Hindawi Puplishing Corporation 01.01.2014
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Témata:
Analysis
Anatomy & physiology
Animals
Biocompatibility
Biocompatible Materials
Bioengineering
Cataracts
Diabetic retinopathy
Forecasts and trends
Health aspects
Humans
Hydrogels
Medicine
Molecular structure
Polyvinyl alcohol
Prostheses and Implants
Review
Stress analysis
Transplants & implants
Vitrectomy
Vitreous Body
Italy
ISSN:2314-6133, 2314-6141, 2314-6141
On-line přístup:Získat plný text
Tagy: Přidat tag
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Abstract Vitreoretinal surgery has advanced in numerous directions during recent years. The removal of the vitreous body is one of the main characteristics of this surgical procedure. Several molecules have been tested in the past to fill the vitreous cavity and to mimic its functions. We here review the currently available vitreous substitutes, focusing on their molecular properties and functions, together with their adverse effects. Afterwards we describe the characteristics of the ideal vitreous substitute. The challenges facing every ophthalmology researcher are to reach a long-term intraocular permanence of vitreous substitute with total inertness of the molecule injected and the control of inflammatory reactions. We report new polymers with gelification characteristics and smart hydrogels representing the future of vitreoretinal surgery. Finally, we describe the current studies on vitreous regeneration and cell cultures to create new intraocular gels with optimal biocompatibility and rheological properties.
AbstractList Vitreoretinal surgery has advanced in numerous directions during recent years. The removal of the vitreous body is one of the main characteristics of this surgical procedure. Several molecules have been tested in the past to fill the vitreous cavity and to mimic its functions. We here review the currently available vitreous substitutes, focusing on their molecular properties and functions, together with their adverse effects. Afterwards we describe the characteristics of the ideal vitreous substitute. The challenges facing every ophthalmology researcher are to reach a long-term intraocular permanence of vitreous substitute with total inertness of the molecule injected and the control of inflammatory reactions. We report new polymers with gelification characteristics and smart hydrogels representing the future of vitreoretinal surgery. Finally, we describe the current studies on vitreous regeneration and cell cultures to create new intraocular gels with optimal biocompatibility and rheological properties.
Vitreoretinal surgery has advanced in numerous directions during recent years. The removal of the vitreous body is one of the main characteristics of this surgical procedure. Several molecules have been tested in the past to fill the vitreous cavity and to mimic its functions. We here review the currently available vitreous substitutes, focusing on their molecular properties and functions, together with their adverse effects. Afterwards we describe the characteristics of the ideal vitreous substitute. The challenges facing every ophthalmology researcher are to reach a long-term intraocular permanence of vitreous substitute with total inertness of the molecule injected and the control of inflammatory reactions. We report new polymers with gelification characteristics and smart hydrogels representing the future of vitreoretinal surgery. Finally, we describe the current studies on vitreous regeneration and cell cultures to create new intraocular gels with optimal biocompatibility and rheological properties.Vitreoretinal surgery has advanced in numerous directions during recent years. The removal of the vitreous body is one of the main characteristics of this surgical procedure. Several molecules have been tested in the past to fill the vitreous cavity and to mimic its functions. We here review the currently available vitreous substitutes, focusing on their molecular properties and functions, together with their adverse effects. Afterwards we describe the characteristics of the ideal vitreous substitute. The challenges facing every ophthalmology researcher are to reach a long-term intraocular permanence of vitreous substitute with total inertness of the molecule injected and the control of inflammatory reactions. We report new polymers with gelification characteristics and smart hydrogels representing the future of vitreoretinal surgery. Finally, we describe the current studies on vitreous regeneration and cell cultures to create new intraocular gels with optimal biocompatibility and rheological properties.
Audience Academic
Author Bartalena, Luigi
Donati, Simone
Vinciguerra, Riccardo
Airaghi, Giulia
Mariotti, Cesare
Porta, Giovanni
Simonelli, Francesca
Azzolini, Claudio
Testa, Francesco
Caprani, Simona Maria
AuthorAffiliation 4 Department of Ophthalmology, Polytechnic University of Ancona, 60121 Ancona, Italy
2 Endocrine Unit, Department of Clinical and Experimental Medicine, School of Medicine, University of Insubria, 21100 Varese, Italy
3 Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Naples, 80121 Naples, Italy
5 Genetic Laboratory, Department of Surgical and Morphological Sciences, School of Medicine, University of Insubria, 21100 Varese, Italy
1 Department of Surgical and Morphological Sciences, Section of Ophthalmology, School of Medicine, University of Insubria, Via Guicciardini 9, 21100 Varese, Italy
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– name: 3 Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Naples, 80121 Naples, Italy
– name: 1 Department of Surgical and Morphological Sciences, Section of Ophthalmology, School of Medicine, University of Insubria, Via Guicciardini 9, 21100 Varese, Italy
– name: 4 Department of Ophthalmology, Polytechnic University of Ancona, 60121 Ancona, Italy
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/24877085$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Contributor Bartalena, Luigi
Donati, Simone
Vinciguerra, Riccardo
Airaghi, Giulia
Mariotti, Cesare
Porta, Giovanni
Simonelli, Francesca
Azzolini, Claudio
Testa, Francesco
Caprani, Simona Maria
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Copyright Copyright © 2014 Simone Donati et al.
COPYRIGHT 2014 John Wiley & Sons, Inc.
Copyright © 2014 Simone Donati et al. Simone Donati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2014 Simone Donati et al. 2014
Copyright_xml – notice: Copyright © 2014 Simone Donati et al.
– notice: COPYRIGHT 2014 John Wiley & Sons, Inc.
– notice: Copyright © 2014 Simone Donati et al. Simone Donati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright © 2014 Simone Donati et al. 2014
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Issue 2014
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Snippet Vitreoretinal surgery has advanced in numerous directions during recent years. The removal of the vitreous body is one of the main characteristics of this...
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StartPage 1
SubjectTerms Analysis
Anatomy & physiology
Animals
Biocompatibility
Biocompatible Materials
Bioengineering
Cataracts
Diabetic retinopathy
Forecasts and trends
Health aspects
Humans
Hydrogels
Medicine
Molecular structure
Polyvinyl alcohol
Prostheses and Implants
Review
Stress analysis
Transplants & implants
Vitrectomy
Vitreous Body
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Title Vitreous Substitutes : The Present and the Future
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https://dx.doi.org/10.1155/2014/351804
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Volume 2014
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