Biomarkers of aging for the identification and evaluation of longevity interventions

With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of st...

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Vydáno v:Cell Ročník 186; číslo 18; s. 3758
Hlavní autoři: Moqri, Mahdi, Herzog, Chiara, Poganik, Jesse R, Justice, Jamie, Belsky, Daniel W, Higgins-Chen, Albert, Moskalev, Alexey, Fuellen, Georg, Cohen, Alan A, Bautmans, Ivan, Widschwendter, Martin, Ding, Jingzhong, Fleming, Alexander, Mannick, Joan, Han, Jing-Dong Jackie, Zhavoronkov, Alex, Barzilai, Nir, Kaeberlein, Matt, Cummings, Steven, Kennedy, Brian K, Ferrucci, Luigi, Horvath, Steve, Verdin, Eric, Maier, Andrea B, Snyder, Michael P, Sebastiano, Vittorio, Gladyshev, Vadim N
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 31.08.2023
Témata:
Aging
Biomarkers
Humans
Longevity
ISSN:1097-4172, 1097-4172
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Abstract With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.
AbstractList With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.
With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.
Author Bautmans, Ivan
Sebastiano, Vittorio
Fuellen, Georg
Horvath, Steve
Mannick, Joan
Zhavoronkov, Alex
Widschwendter, Martin
Belsky, Daniel W
Kennedy, Brian K
Verdin, Eric
Cummings, Steven
Ferrucci, Luigi
Moskalev, Alexey
Gladyshev, Vadim N
Han, Jing-Dong Jackie
Snyder, Michael P
Moqri, Mahdi
Ding, Jingzhong
Kaeberlein, Matt
Cohen, Alan A
Barzilai, Nir
Higgins-Chen, Albert
Justice, Jamie
Poganik, Jesse R
Maier, Andrea B
Herzog, Chiara
Fleming, Alexander
Author_xml – sequence: 1
  givenname: Mahdi
  surname: Moqri
  fullname: Moqri, Mahdi
  organization: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Genetics, School of Medicine, Stanford University, Stanford, CA, USA; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, USA
– sequence: 2
  givenname: Chiara
  surname: Herzog
  fullname: Herzog, Chiara
  organization: European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria
– sequence: 3
  givenname: Jesse R
  surname: Poganik
  fullname: Poganik, Jesse R
  organization: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
– sequence: 4
  givenname: Jamie
  surname: Justice
  fullname: Justice, Jamie
  organization: Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA
– sequence: 5
  givenname: Daniel W
  surname: Belsky
  fullname: Belsky, Daniel W
  organization: Department of Epidemiology, Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA
– sequence: 6
  givenname: Albert
  surname: Higgins-Chen
  fullname: Higgins-Chen, Albert
  organization: Department of Psychiatry, Yale University, New Haven, CT, USA
– sequence: 7
  givenname: Alexey
  surname: Moskalev
  fullname: Moskalev, Alexey
  organization: Institute of Biogerontology, Lobachevsky University, Nizhny Novgorod, Russia
– sequence: 8
  givenname: Georg
  surname: Fuellen
  fullname: Fuellen, Georg
  organization: Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, Rostock, Germany; School of Medicine, University College Dublin, Dublin, Ireland
– sequence: 9
  givenname: Alan A
  surname: Cohen
  fullname: Cohen, Alan A
  organization: Department of Environmental Health Sciences, Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA
– sequence: 10
  givenname: Ivan
  surname: Bautmans
  fullname: Bautmans, Ivan
  organization: Gerontology Department, Vrije Universiteit Brussel, Brussels, Belgium; Frailty in Ageing Research Department, Vrije Universiteit Brussel, Brussels, Belgium
– sequence: 11
  givenname: Martin
  surname: Widschwendter
  fullname: Widschwendter, Martin
  organization: European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria; Department of Women's Cancer, EGA Institute for Women's Health, University College London, London, UK; Department of Women's and Children's Health, Division of Obstetrics and Gynaecology, Karolinska Institutet, Stockholm, Sweden
– sequence: 12
  givenname: Jingzhong
  surname: Ding
  fullname: Ding, Jingzhong
  organization: Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA
– sequence: 13
  givenname: Alexander
  surname: Fleming
  fullname: Fleming, Alexander
  organization: Kitalys Institute, Charlottesville, VA, USA
– sequence: 14
  givenname: Joan
  surname: Mannick
  fullname: Mannick, Joan
  organization: Tornado Therapeutics, New York, NY, USA
– sequence: 15
  givenname: Jing-Dong Jackie
  surname: Han
  fullname: Han, Jing-Dong Jackie
  organization: Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology, Peking University, Beijing, China
– sequence: 16
  givenname: Alex
  surname: Zhavoronkov
  fullname: Zhavoronkov, Alex
  organization: Insilico Medicine Hong Kong, Pak Shek Kok, New Territories, Hong Kong SAR, China
– sequence: 17
  givenname: Nir
  surname: Barzilai
  fullname: Barzilai, Nir
  organization: Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA
– sequence: 18
  givenname: Matt
  surname: Kaeberlein
  fullname: Kaeberlein, Matt
  organization: Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA
– sequence: 19
  givenname: Steven
  surname: Cummings
  fullname: Cummings, Steven
  organization: San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA
– sequence: 20
  givenname: Brian K
  surname: Kennedy
  fullname: Kennedy, Brian K
  organization: Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
– sequence: 21
  givenname: Luigi
  surname: Ferrucci
  fullname: Ferrucci, Luigi
  organization: National Institute on Aging, Baltimore, MD, USA
– sequence: 22
  givenname: Steve
  surname: Horvath
  fullname: Horvath, Steve
  organization: Altos Labs, San Diego, CA, USA
– sequence: 23
  givenname: Eric
  surname: Verdin
  fullname: Verdin, Eric
  organization: Buck Institute for Research on Aging, Novato, CA, USA
– sequence: 24
  givenname: Andrea B
  surname: Maier
  fullname: Maier, Andrea B
  organization: Department of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Centre for Healthy Longevity, @AgeSingapore, National University Health System, Singapore, Singapore
– sequence: 25
  givenname: Michael P
  surname: Snyder
  fullname: Snyder, Michael P
  email: mpsnyder@stanford.edu
  organization: Department of Genetics, School of Medicine, Stanford University, Stanford, CA, USA. Electronic address: mpsnyder@stanford.edu
– sequence: 26
  givenname: Vittorio
  surname: Sebastiano
  fullname: Sebastiano, Vittorio
  email: vsebast@stanford.edu
  organization: Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, USA. Electronic address: vsebast@stanford.edu
– sequence: 27
  givenname: Vadim N
  surname: Gladyshev
  fullname: Gladyshev, Vadim N
  email: vgladyshev@rics.bwh.harvard.edu
  organization: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: vgladyshev@rics.bwh.harvard.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37657418$$D View this record in MEDLINE/PubMed
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Snippet With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field....
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SubjectTerms Aging
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Title Biomarkers of aging for the identification and evaluation of longevity interventions
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