Biomarkers of aging for the identification and evaluation of longevity interventions

With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of st...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Cell Ročník 186; číslo 18; s. 3758
Hlavní autori: Moqri, Mahdi, Herzog, Chiara, Poganik, Jesse R, Justice, Jamie, Belsky, Daniel W, Higgins-Chen, Albert, Moskalev, Alexey, Fuellen, Georg, Cohen, Alan A, Bautmans, Ivan, Widschwendter, Martin, Ding, Jingzhong, Fleming, Alexander, Mannick, Joan, Han, Jing-Dong Jackie, Zhavoronkov, Alex, Barzilai, Nir, Kaeberlein, Matt, Cummings, Steven, Kennedy, Brian K, Ferrucci, Luigi, Horvath, Steve, Verdin, Eric, Maier, Andrea B, Snyder, Michael P, Sebastiano, Vittorio, Gladyshev, Vadim N
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 31.08.2023
Predmet:
Aging
Biomarkers
Humans
Longevity
ISSN:1097-4172, 1097-4172
On-line prístup:Zistit podrobnosti o prístupe
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2023.08.003