Genetic architecture: the shape of the genetic contribution to human traits and disease

Key Points The genetic architecture of common diseases is central to the scientific and clinical goals of human genetics because it directly impacts biology, disease screening, diagnosis, prognosis and treatment. Genetic architecture is currently assessed by exploiting the differences in types of ge...

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Bibliographic Details
Published in:	Nature reviews. Genetics Vol. 19; no. 2; pp. 110 - 124
Main Authors:	Timpson, Nicholas J., Greenwood, Celia M. T., Soranzo, Nicole, Lawson, Daniel J., Richards, J. Brent
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.02.2018 Nature Publishing Group
Subjects:	631/208/205/2138 631/208/212/2301 631/208/2489/144 631/208/457/649 631/208/514/2254 631/208/729 692/700/478/174 Agriculture Animal Genetics and Genomics Biomedicine Cancer Research Gene Function Genetic Diseases, Inborn - diagnosis Genetic Diseases, Inborn - genetics Genetic diversity Genetic engineering Genetic research Genetic variability Genetic variation Genome-wide association studies Genome-Wide Association Study Genomes Genotype & phenotype Human Genetics Humans Identification and classification Multifactorial Inheritance Polymorphism, Single Nucleotide Quantitative Trait, Heritable review-article
ISSN:	1471-0056, 1471-0064, 1471-0064
Online Access:	Get full text
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