Genetic architecture: the shape of the genetic contribution to human traits and disease

Genetic architecture describes the characteristics of genetic variation that are responsible for heritable phenotypic variability. It depends on the number of genetic variants affecting a trait, their frequencies in the population, the magnitude of their effects and their interactions with each othe...

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Vydáno v:	Nature reviews. Genetics Ročník 19; číslo 2; s. 110
Hlavní autoři:	Timpson, Nicholas J, Greenwood, Celia M T, Soranzo, Nicole, Lawson, Daniel J, Richards, J Brent
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Nature Publishing Group 01.02.2018
Témata:	Genetic Diseases, Inborn - diagnosis Genetic Diseases, Inborn - genetics Genetic diversity Genetic variability Genome-wide association studies Genome-Wide Association Study Genomes Genotype & phenotype Humans Multifactorial Inheritance Polymorphism, Single Nucleotide Quantitative Trait, Heritable
ISSN:	1471-0056, 1471-0064, 1471-0064
On-line přístup:	Získat plný text
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