Common variants in the GDF5-UQCC region are associated with variation in human height

Identifying genetic variants that influence human height will advance our understanding of skeletal growth and development. Several rare genetic variants have been convincingly and reproducibly associated with height in mendelian syndromes, and common variants in the transcription factor gene HMGA2...

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Vydáno v:	Nature genetics Ročník 40; číslo 2; s. 198 - 203
Hlavní autoři:	Sanna, Serena, Jackson, Anne U, Nagaraja, Ramaiah, Willer, Cristen J, Chen, Wei-Min, Bonnycastle, Lori L, Shen, Haiqing, Timpson, Nicholas, Lettre, Guillaume, Usala, Gianluca, Chines, Peter S, Stringham, Heather M, Scott, Laura J, Dei, Mariano, Lai, Sandra, Albai, Giuseppe, Crisponi, Laura, Naitza, Silvia, Doheny, Kimberly F, Pugh, Elizabeth W, Ben-Shlomo, Yoav, Ebrahim, Shah, Lawlor, Debbie A, Bergman, Richard N, Watanabe, Richard M, Uda, Manuela, Tuomilehto, Jaakko, Coresh, Josef, Hirschhorn, Joel N, Shuldiner, Alan R, Schlessinger, David, Collins, Francis S, Smith, George Davey, Boerwinkle, Eric, Cao, Antonio, Boehnke, Michael, Abecasis, Gonçalo R, Mohlke, Karen L
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Nature Publishing Group US 01.02.2008 Nature Publishing Group
Témata:	5' Untranslated Regions Aged Agriculture Alleles Animal Genetics and Genomics Arthritis Biological and medical sciences Biomedical and Life Sciences Biomedicine Black or African American Body Height - genetics Body Mass Index Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Cancer Research Chromosomes, Human, Pair 20 Confounding Factors, Epidemiologic Female Fundamental and applied biological sciences. Psychology Gene Dosage Gene Frequency Gene Function Genetic aspects Genetic Markers Genetic variance Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Genome, Human Genotype & phenotype Growth Differentiation Factor 5 Haplotypes Height HMGA2 Protein - genetics Human Genetics Humans letter Linkage Disequilibrium Male Middle Aged Osteoarthritis Osteoarthritis - genetics Physiological aspects Polymorphism, Single Nucleotide Probability Recombinant Proteins - metabolism Regression Analysis Risk factors Stature Italy Human Variant
ISSN:	1061-4036, 1546-1718, 1546-1718
On-line přístup:	Získat plný text
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