Metabolomic Profiling of Drug Responses in Acute Myeloid Leukaemia Cell Lines

Combined bezafibrate (BEZ) and medroxyprogesterone acetate (MPA) exert unexpected antileukaemic activities against acute myeloid leukaemia (AML) and these activities are associated with the generation of reactive oxygen species (ROS) within the tumor cells. Although the generation of ROS by these dr...

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Bibliographic Details
Published in:	PloS one Vol. 4; no. 1; p. e4251
Main Authors:	Tiziani, Stefano, Lodi, Alessia, Khanim, Farhat L., Viant, Mark R., Bunce, Christopher M., Günther, Ulrich L.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 22.01.2009 Public Library of Science (PLoS)
Subjects:	Acetic acid Acute myeloid leukemia Antigens Antineoplastic Agents - pharmacology Apoptosis Bezafibrate Biosynthesis Biotechnology Cancer therapies Cell Biology/Chemical Biology of the Cell Cell Differentiation Cell Line, Tumor Chemical Biology/Chemical Biology of the Cell Chemical Biology/Small Molecule Chemistry Chemistry/Biochemistry Data processing Drug Design Drug Screening Assays, Antitumor - methods Drugs External stimuli HL-60 Cells Humans Hydrogen Hydrogen peroxide Intermediates K562 Cells Ketoglutaric acid Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - metabolism Magnetic Resonance Spectroscopy Medroxyprogesterone acetate Metabolism Metabolites Metabolomics Metabolomics - methods Morphology NMR Nuclear magnetic resonance Oxygen Oxygen - metabolism Phenotype Principal components analysis Reactive Oxygen Species Spectrum analysis Studies Time Factors Tricarboxylic acid cycle Tumor cells United Kingdom > UK
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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