Deficiency for the Chemokine Monocyte Chemoattractant Protein-1 Aggravates Tubular Damage after Renal Ischemia/Reperfusion Injury

Temporal expression of chemokines is a crucial factor in the regulation of renal ischemia/reperfusion (I/R) injury and repair. Beside their role in the migration and activation of inflammatory cells to sites of injury, chemokines are also involved in other processes such as angiogenesis, development...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 4; p. e0123203
Main Authors:	Stroo, Ingrid, Claessen, Nike, Teske, Gwendoline J. D., Butter, Loes M., Florquin, Sandrine, Leemans, Jaklien C.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 13.04.2015 Public Library of Science (PLoS)
Subjects:	Accumulation Analgesics Animals Apoptosis Apoptosis - genetics Butter Chemokine CCL2 - deficiency Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Chemokines Cytokines - genetics Cytokines - metabolism Disease Models, Animal Gene Expression Genes, Lethal Growth factors Inflammatory response Injuries Ischemia Kidney Tubules - metabolism Kidney Tubules - pathology Kidneys Leukocytes - metabolism Macrophages Macrophages - metabolism Male Mice Mice, Knockout Migration Neutrophils Oxidative stress Pathology Peroxidase - metabolism Proteins Reperfusion Injury - genetics Reperfusion Injury - metabolism Reperfusion Injury - pathology RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Stem cells Surgery Time Factors Up-Regulation Belgium Netherlands
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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