Fibronectin Affects Transient MMP2 Gene Expression through DNA Demethylation Changes in Non-Invasive Breast Cancer Cell Lines

Metastasis accounts for more than 90% of cancer deaths. Cells from primary solid tumors may invade adjacent tissues and migrate to distant sites where they establish new colonies. The tumor microenvironment is now recognized as an important participant in the signaling that induces cancer cell migra...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 9; p. e105806
Main Authors:	Pereira, Isabela T., Ramos, Edneia A. S., Costa, Erico T., Camargo, Anamaria A., Manica, Graciele C. M., Klassen, Liliane M. B., Chequin, Andressa, Braun-Prado, Karin, de O. Pedrosa, Fábio, Souza, Emanuel M., Costa, Fabricio F., Klassen, Giseli
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 10.09.2014 Public Library of Science (PLoS)
Subjects:	Azacitidine - analogs & derivatives Azacitidine - pharmacology Base Sequence Biochemistry Biology and Life Sciences Blood vessels Breast cancer Breast Neoplasms - pathology Cancer Cancer therapies Cell culture Cell Line, Tumor Cell migration Cell Movement - drug effects Chromatin Collagen (type IV) Degradation Demethylation Deoxyribonucleic acid DNA DNA methylation DNA Methylation - drug effects Epigenetics Epithelial cells Extracellular matrix Fibronectin Fibronectins - pharmacology Gelatinase Gelatinase A Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Humans Matrix Metalloproteinase 2 - genetics Medical research Metastases Metastasis Molecular biology Molecular Sequence Data Neoplasm Invasiveness Oncology Pathology Promoter Regions, Genetic - genetics Proteins RNA polymerase Solid tumors Stroma Time Factors Tissues Transcriptional Activation - drug effects Tumor cell lines Tumor cells Tumors Brazil United States > US Chicago Illinois
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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