NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma

Immunomodulators are effective in controlling hematologic malignancy by initiating or reactivating host antitumor immunity to otherwise poorly immunogenic and immune suppressive cancers. We aimed to boost antitumor immunity in B-cell lymphoma by developing a tumor cell vaccine incorporating α-galact...

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Bibliographic Details
Published in:	Blood Vol. 120; no. 15; p. 3019
Main Authors:	Mattarollo, Stephen R, West, Alison C, Steegh, Kim, Duret, Helene, Paget, Christophe, Martin, Ben, Matthews, Geoffrey M, Shortt, Jake, Chesi, Marta, Bergsagel, P Leif, Bots, Michael, Zuber, Johannes, Lowe, Scott W, Johnstone, Ricky W, Smyth, Mark J
Format:	Journal Article
Language:	English
Published:	United States 11.10.2012
Subjects:	Adjuvants, Immunologic - administration & dosage Animals Cancer Vaccines - therapeutic use Cytotoxicity, Immunologic - immunology Female Flow Cytometry Galactosylceramides - administration & dosage Genes, myc - genetics Genes, T-Cell Receptor delta - physiology Humans Immunotherapy Interferon-gamma - metabolism Interleukin-12 - physiology Interleukin-18 - physiology Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Killer Cells, Natural - pathology Lymphoma, B-Cell - immunology Lymphoma, B-Cell - metabolism Lymphoma, B-Cell - prevention & control Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Natural Killer T-Cells - immunology Natural Killer T-Cells - metabolism Natural Killer T-Cells - pathology Vaccination
ISSN:	1528-0020, 1528-0020
Online Access:	Get more information
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