Patient Reported Differences in Dry Eye Disease between Men and Women: Impact, Management, and Patient Satisfaction

Dry eye disease affects women twice as often as men, but there is little information on whether dry eye treatments, treatment satisfaction, or the impact of dry eye disease on patients' lives and vision might differ by sex. Questionnaire survey of 4000 participants in the Women's Health St...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	PloS one Ročník 8; číslo 9; s. e76121
Hlavní autoři:	Schaumberg, Debra A., Uchino, Miki, Christen, William G., Semba, Richard D., Buring, Julie E., Li, Jim Z.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 30.09.2013 Public Library of Science (PLoS)
Témata:	Aged Cancer Cardiovascular disease Diagnosis Disease control Disease prevention Drug dosages Dry Eye Syndromes - drug therapy Dry Eye Syndromes - pathology Epidemiology Eye Eye diseases Fatty acids Female Gender differences Health care Health risk assessment Hospitals Humans Male Medical personnel Medical schools Medical treatment Men Mens health Occlusion Occupational health Odds Ratio Omega-3 fatty acids Pain Patient satisfaction Patient Satisfaction - statistics & numerical data Physicians Population Population studies Preventive medicine Professionals Public health Questionnaires Regression Analysis Regression models Risk factors Sex Factors Side effects Studies Surveys and Questionnaires Systematic review Tears Treatment Outcome United States Vitamin A Well being Womens health United States United States > US Massachusetts
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Dry eye disease affects women twice as often as men, but there is little information on whether dry eye treatments, treatment satisfaction, or the impact of dry eye disease on patients' lives and vision might differ by sex. Questionnaire survey of 4000 participants in the Women's Health Study and the Physicians' Health Studies I and II with a prior report of a diagnosis of DED. Among participants who re-confirmed a diagnosis of dry eye disease, we assessed symptoms, treatments, patient satisfaction and impact of dry eye disease, and analyzed differences between men and women using regression models. The final study population consisted of 1,518 women (mean age 70.7 years) and 581 men (mean age 76.7 years), with a mean reported duration of dry eye disease of 10.5 years and 10.1 years, respectively. The frequency and severity of dry eye disease symptoms were higher among women (each P<0.0001), and women reported a greater impact on everyday activities (P<0.0001). Women were more likely to use artificial tears (P<0.0001) use them more often (P<0.0001), and to use Restasis® (P<0.0001), omega-3 fatty acids (P=0.0006), and have punctal occlusion (P=0.005). Women spent more money per month on dry eye treatments (P<0.0001), but reported greater dissatisfaction with treatment side effects (P=0.001), and the amount of time before treatments started working (P=0.03). These data show that dry eye disease is generally experienced as being more severe among women, having a greater impact on their self-assessed well-being.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: DAS. Performed the experiments: DAS WGC JEB. Analyzed the data: DAS. Contributed reagents/materials/analysis tools: DAS WGC RDS JEB JZL. Wrote the manuscript: DAS MU JZL. Competing Interests: This study was partly funded by Pfizer, the employer of Jim Z. Li. Dr. Li held equity interest in Pfizer, Inc. Dr. Schaumberg was a periodic consultant for Pfizer, Inc. (on other topics not overlapping with the submitted work), as well as Alcon, Eleven Biotherapeutics, Inspire Pharmaceuticals, and Allergan, Inc.; and held equity interest in TearLab, Inc. and Mimetogen Pharmaceuticals. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0076121