Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

Most genome-wide association and fine-mapping studies to date have been conducted in individuals of European descent, and genetic studies of populations of Hispanic/Latino and African ancestry are limited. In addition, these populations have more complex linkage disequilibrium structure. In order to...

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Vydané v:	PLoS genetics Ročník 15; číslo 12; s. e1008500
Hlavní autori:	Kowalski, Madeline H., Qian, Huijun, Hou, Ziyi, Rosen, Jonathan D., Tapia, Amanda L., Shan, Yue, Jain, Deepti, Argos, Maria, Arnett, Donna K., Avery, Christy, Barnes, Kathleen C., Becker, Lewis C., Bien, Stephanie A., Bis, Joshua C., Blangero, John, Boerwinkle, Eric, Bowden, Donald W., Buyske, Steve, Cai, Jianwen, Cho, Michael H., Choi, Seung Hoan, Choquet, Hélène, Cupples, L. Adrienne, Cushman, Mary, Daya, Michelle, de Vries, Paul S., Ellinor, Patrick T., Faraday, Nauder, Fornage, Myriam, Gabriel, Stacey, Ganesh, Santhi K., Graff, Misa, Gupta, Namrata, He, Jiang, Heckbert, Susan R., Hidalgo, Bertha, Hodonsky, Chani J., Irvin, Marguerite R., Johnson, Andrew D., Jorgenson, Eric, Kaplan, Robert, Kardia, Sharon L. R., Kelly, Tanika N., Kooperberg, Charles, Lasky-Su, Jessica A., Loos, Ruth J. F., Lubitz, Steven A., Mathias, Rasika A., McHugh, Caitlin P., Montgomery, Courtney, Moon, Jee-Young, Morrison, Alanna C., Palmer, Nicholette D., Pankratz, Nathan, Papanicolaou, George J., Peralta, Juan M., Peyser, Patricia A., Rich, Stephen S., Rotter, Jerome I., Silverman, Edwin K., Smith, Jennifer A., Smith, Nicholas L., Taylor, Kent D., Thornton, Timothy A., Tiwari, Hemant K., Tracy, Russell P., Wang, Tao, Weiss, Scott T., Weng, Lu-Chen, Wiggins, Kerri L., Wilson, James G., Yanek, Lisa R., Zöllner, Sebastian, North, Kari E., Auer, Paul L., Raffield, Laura M., Reiner, Alexander P., Li, Yun
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 01.12.2019 Public Library of Science (PLoS)
Predmet:	Adult Aged Aged, 80 and over Alleles beta-Globins - genetics Biology and Life Sciences Black or African American - genetics Cardiac arrhythmia College campuses Computational Biology - methods Databases, Genetic Environmental science Epidemiology Female Gene Frequency Gene mapping Genetic Predisposition to Disease Genetics, Population Genome-Wide Association Study Genomes Genomics Genotypes Genotyping Genotyping Techniques Haplotypes HBB gene Health sciences Hematocrit Hemoglobin Hispanic or Latino - genetics Hospitals Humans Linkage Disequilibrium Male Medical research Medicine Medicine and Health Sciences Middle Aged Population genetics Population studies Precision medicine Precision Medicine - methods Public health Research and Analysis Methods Social Sciences United States Whole genome sequencing Whole Genome Sequencing - methods United States North Carolina New York United States > US California Alabama Ann Arbor Michigan Michigan Los Angeles California Colorado Texas Massachusetts Northern California Maryland Baltimore Maryland
ISSN:	1553-7404, 1553-7390, 1553-7404
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