A systems biology analysis of brain microvascular endothelial cell lipotoxicity

Background Neurovascular inflammation is associated with a number of neurological diseases including vascular dementia and Alzheimer’s disease, which are increasingly important causes of morbidity and mortality around the world. Lipotoxicity is a metabolic disorder that results from accumulation of...

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Bibliographic Details
Published in:	BMC systems biology Vol. 8; no. 1; p. 80
Main Authors:	Aung, Hnin H, Tsoukalas, Athanasios, Rutledge, John C, Tagkopoulos, Ilias
Format:	Journal Article
Language:	English
Published:	London BioMed Central 04.07.2014 BioMed Central Ltd
Subjects:	Activating Transcription Factor 3 - metabolism Adipose tissue Algorithms Alzheimer's disease Apoptosis - drug effects Bioinformatics Biomedical and Life Sciences Brain - blood supply Cell death Cellular and Medical Topics Cognitive ability Colleges & universities Computational Biology/Bioinformatics Dementia Dementia disorders DNA binding proteins Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium Gene Expression Regulation - drug effects Genes Genetic transcription Genomes Health aspects Humans Life Sciences Lipid Metabolism - drug effects Lipids Lipolysis - drug effects Lipoproteins - chemistry Lipoproteins - pharmacology Metabolic Diseases - metabolism Metabolic Diseases - pathology Metabolic disorders Microvessels - pathology Ontology pharmacology and medicine Physiological Proteins Research Article Signal Transduction - drug effects Simulation and Modeling Statistical methods Systems Biology Systems physiology Transcription factors Triglycerides - chemistry Microarray Activating transcription factor 3 Triglyceride-rich lipoprotein Blood–brain barrier
ISSN:	1752-0509, 1752-0509
Online Access:	Get full text
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