Association of a cystatin C gene variant with cystatin C levels, CKD, and risk of incident cardiovascular disease and mortality

Carriers of the T allele of the single-nucleotide polymorphism rs13038305 tend to have lower cystatin C levels and higher cystatin C-based estimated glomerular filtration rate (eGFRcys). Adjusting for this genetic effect on cystatin C concentrations may improve GFR estimation, reclassify cases of ch...

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Veröffentlicht in:	American journal of kidney diseases Jg. 63; H. 1; S. 16
Hauptverfasser:	O'Seaghdha, Conall M, Tin, Adrienne, Yang, Qiong, Katz, Ronit, Liu, Yongmei, Harris, Tamara, Astor, Brad, Coresh, Josef, Fox, Caroline S, Kao, W H Linda, Shlipak, Michael G
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.01.2014
Schlagworte:	Aged Bias Biomarkers - blood Cardiovascular Diseases - blood Cardiovascular Diseases - genetics Cardiovascular Diseases - mortality Creatinine - blood Cystatin C - blood Cystatin C - genetics Female Genetic Variation Glomerular Filtration Rate - genetics Humans Male Middle Aged Polymorphism, Single Nucleotide Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - classification Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - genetics Renal Insufficiency, Chronic - physiopathology Risk Assessment Risk Factors Severity of Illness Index Statistics as Topic Survival Rate net reclassification improvement chronic kidney disease genetics single-nucleotide polymorphism Cystatin C
ISSN:	1523-6838, 1523-6838
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