MicroRNA-223 coordinates cholesterol homeostasis

MicroRNAs (miRNAs) regulate a wide variety of biological processes and contribute to metabolic homeostasis. Here, we demonstrate that microRNA-223 (miR-223), an miRNA previously associated with inflammation, also controls multiple mechanisms associated with cholesterol metabolism. miR-223 promoter a...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 40; p. 14518
Main Authors:	Vickers, Kasey C, Landstreet, Stuart R, Levin, Michael G, Shoucri, Bassem M, Toth, Cynthia L, Taylor, Robert C, Palmisano, Brian T, Tabet, Fatiha, Cui, Huanhuan L, Rye, Kerry-Anne, Sethupathy, Praveen, Remaley, Alan T
Format:	Journal Article
Language:	English
Published:	United States 07.10.2014
Subjects:	Animals Cell Line, Tumor Cells, Cultured Cholesterol - metabolism Cholesterol, HDL - metabolism HEK293 Cells Homeostasis Humans Liver - metabolism Mice, Knockout MicroRNAs - genetics Models, Genetic Oligonucleotide Array Sequence Analysis Reverse Transcriptase Polymerase Chain Reaction Transcriptome - genetics atherosclerosis reverse cholesterol transport posttranscriptional gene regulation
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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