Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome

Tourette syndrome (TS) is a model neuropsychiatric disorder thought to arise from abnormal development and/or maintenance of cortico-striato-thalamo-cortical circuits. TS is highly heritable, but its underlying genetic causes are still elusive, and no genome-wide significant loci have been discovere...

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Vydáno v:	Neuron (Cambridge, Mass.) Ročník 94; číslo 6; s. 1101
Hlavní autoři:	Huang, Alden Y, Yu, Dongmei, Davis, Lea K, Sul, Jae Hoon, Tsetsos, Fotis, Ramensky, Vasily, Zelaya, Ivette, Ramos, Eliana Marisa, Osiecki, Lisa, Chen, Jason A, McGrath, Lauren M, Illmann, Cornelia, Sandor, Paul, Barr, Cathy L, Grados, Marco, Singer, Harvey S, Nöthen, Markus M, Hebebrand, Johannes, King, Robert A, Dion, Yves, Rouleau, Guy, Budman, Cathy L, Depienne, Christel, Worbe, Yulia, Hartmann, Andreas, Müller-Vahl, Kirsten R, Stuhrmann, Manfred, Aschauer, Harald, Stamenkovic, Mara, Schloegelhofer, Monika, Konstantinidis, Anastasios, Lyon, Gholson J, McMahon, William M, Barta, Csaba, Tarnok, Zsanett, Nagy, Peter, Batterson, James R, Rizzo, Renata, Cath, Danielle C, Wolanczyk, Tomasz, Berlin, Cheston, Malaty, Irene A, Okun, Michael S, Woods, Douglas W, Rees, Elliott, Pato, Carlos N, Pato, Michele T, Knowles, James A, Posthuma, Danielle, Pauls, David L, Cox, Nancy J, Neale, Benjamin M, Freimer, Nelson B, Paschou, Peristera, Mathews, Carol A, Scharf, Jeremiah M, Coppola, Giovanni
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 21.06.2017
Témata:	Adolescent Adult Calcium-Binding Proteins Case-Control Studies Cell Adhesion Molecules, Neuronal - genetics Child Contactins - genetics DNA Copy Number Variations Female Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Male Nerve Tissue Proteins - genetics Neural Cell Adhesion Molecules Odds Ratio Tourette Syndrome - genetics White People - genetics Young Adult structural variation genetics copy number variation CNTN6 NRXN1 Tourette Syndrome tic disorders neurodevelopmental disorders
ISSN:	1097-4199, 1097-4199
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