Ectopic fat obesity presents the greatest risk for incident type 2 diabetes: a population-based longitudinal study

Obesity is a risk factor for type 2 diabetes mellitus. Among obesity, visceral fat obesity, and ectopic fat obesity, it has been unclear which has the greatest effect on incident diabetes. In this historical cohort study of 8430 men and 7034 women, we investigated the effect of obesity phenotypes on...

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Vydané v:International Journal of Obesity Ročník 43; číslo 1; s. 139 - 148
Hlavní autori: Okamura, Takuro, Hashimoto, Yoshitaka, Hamaguchi, Masahide, Obora, Akihiro, Kojima, Takao, Fukui, Michiaki
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Nature Publishing Group 01.01.2019
Predmet:
Adult
Body Mass Index
Body size
Correlation analysis
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - etiology
Diabetes Mellitus, Type 2 - physiopathology
Fatty liver
Female
Health risk assessment
Humans
Intra-Abdominal Fat - pathology
Japan - epidemiology
Liver
Longitudinal Studies
Male
Men
Middle Aged
Obesity
Obesity - complications
Obesity - epidemiology
Obesity - physiopathology
Phenotypes
Population studies
Population-based studies
Risk analysis
Risk Factors
Ultrasound
Japan
ISSN:0307-0565, 1476-5497, 1476-5497
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Shrnutí:Obesity is a risk factor for type 2 diabetes mellitus. Among obesity, visceral fat obesity, and ectopic fat obesity, it has been unclear which has the greatest effect on incident diabetes. In this historical cohort study of 8430 men and 7034 women, we investigated the effect of obesity phenotypes on incident diabetes. Obesity, visceral fat obesity, and ectopic fat obesity were defined as body mass index ≥25 kg/m , waist circumference ≥90 cm in men or ≥80 cm in women, and having fatty liver diagnosed by abdominal ultrasonography, respectively. We divided the participants into eight groups according to the presence or absence of the three obesity phenotypes. During the median 5.8 years follow-up for men and 5.1 years follow-up for women, 286 men and 87 women developed diabetes. Compared to the non-obese group, the hazard ratios (HRs) of incident diabetes in the only-obesity, only-visceral fat obesity, only-ectopic fat obesity groups, and with all-three types of obesity group were 1.85 (95%CI 1.06-3.26, p = 0.05) in men and 1.79 (0.24-13.21, p = 0.60) in women, 3.41 (2.51-4.64, p < 0.001) in men and 2.30 (0.87-6.05, p = 0.12) in women, 4.74 (1.91-11.70, p < 0.001) in men and 13.99 (7.23-27.09, p < 0.001) in women and 10.5 (8.02-13.8, p < 0.001) in men and 30.0 (18.0-50.0, p < 0.001) in women. Moreover, the risk of incident diabetes of the groups with ectopic fat obesity were almost higher than that of the four groups without ectopic fat obesity. Ectopic fat obesity presented the greatest risk of incident type 2 diabetes.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0307-0565
1476-5497
1476-5497
DOI:10.1038/s41366-018-0076-3