Healthcare Worker Occupation and Immune Response to Pneumocystis jirovecii

The reservoir and mode of transmission of Pneumocystis jirovecii remain uncertain. We conducted a cross-sectional study of 126 San Francisco General Hospital staff in clinical (n = 103) and nonclinical (n = 23) occupations to assess whether occupational exposure was associated with immune responses...

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Vydané v:	Emerging infectious diseases Ročník 15; číslo 10; s. 1590 - 1597
Hlavní autori:	Tipirneni, Renuka, Daly, Kieran R., Jarlsberg, Leah G., Koch, Judy V., Swartzman, Alexandra, Roth, Brenna M., Walzer, Peter D., Huang, Laurence
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States U.S. National Center for Infectious Diseases 01.10.2009 Centers for Disease Control and Prevention
Predmet:	Adult Aged Aged, 80 and over antibodies Antibodies, Fungal - immunology Antiviral agents Causes of Cross-Sectional Studies Drug therapy Female fungal Fungal Proteins - immunology Health aspects Health Personnel HIV/AIDS and other retroviruses Humans Immune response Male Middle Aged Occupational Exposure opportunistic infections Pneumocystis Pneumocystis carinii - immunology Pneumocystis carinii pneumonia Pneumocystis Infections - epidemiology Pneumocystis Infections - immunology Prevention Surveys and Questionnaires Young Adult United States
ISSN:	1080-6040, 1080-6059, 1080-6059
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Abstract	The reservoir and mode of transmission of Pneumocystis jirovecii remain uncertain. We conducted a cross-sectional study of 126 San Francisco General Hospital staff in clinical (n = 103) and nonclinical (n = 23) occupations to assess whether occupational exposure was associated with immune responses to P. jirovecii. We examined antibody levels by ELISA for 3 overlapping fragments that span the P. jirovecii major surface glycoprotein (Msg): MsgA, MsgB, and MsgC1. Clinical occupation participants had higher geometric mean antibody levels to MsgC1 than did nonclinical occupation participants (21.1 vs. 8.2, p = 0.004); clinical occupation was an independent predictor of higher MsgC1 antibody levels (parameter estimate = 0.89, 95% confidence interval 0.29-1.48, p = 0.003). In contrast, occupation was not significantly associated with antibody responses to either MsgA or MsgB. Healthcare workers may have occupational exposure to P. jirovecii. Humans may be a reservoir for P. jirovecii and may transmit it from person to person.
AbstractList	The reservoir and mode of transmission of Pneumocystis jirovecii remain uncertain. We conducted a cross-sectional study of 126 San Francisco General Hospital staff in clinical (n = 103) and nonclinical (n = 23) occupations to assess whether occupational exposure was associated with immune responses to P. jirovecii. We examined antibody levels by ELISA for 3 overlapping fragments that span the P. jirovecii major surface glycoprotein (Msg): MsgA, MsgB, and MsgC1. Clinical occupation participants had higher geometric mean antibody levels to MsgC1 than did nonclinical occupation participants (21.1 vs. 8.2, p = 0.004); clinical occupation was an independent predictor of higher MsgC1 antibody levels (parameter estimate = 0.89, 95% confidence interval 0.29-1.48, p = 0.003). In contrast, occupation was not significantly associated with antibody responses to either MsgA or MsgB. Healthcare workers may have occupational exposure to P. jirovecii. Humans may be a reservoir for P. jirovecii and may transmit it from person to person. The reservoir and mode of transmission of Pneumocystis jirovecii remain uncertain. We conducted a cross-sectional study of 126 San Francisco General Hospital staff in clinical (n = 103) and nonclinical (n = 23) occupations to assess whether occupational exposure was associated with immune responses to P. jirovecii. We examined antibody levels by ELISA for 3 overlapping fragments that span the P. jirovecii major surface glycoprotein (Msg): MsgA, MsgB, and MsgC1. Clinical occupation participants had higher geometric mean antibody levels to MsgC1 than did nonclinical occupation participants (21.1 vs. 8.2, p = 0.004); clinical occupation was an independent predictor of higher MsgC1 antibody levels (parameter estimate = 0.89, 95% confidence interval 0.29-1.48, p = 0.003). In contrast, occupation was not significantly associated with antibody responses to either MsgA or MsgB. Healthcare workers may have occupational exposure to P. jirovecii. Humans may be a reservoir for P. jirovecii and may transmit it from person to person.The reservoir and mode of transmission of Pneumocystis jirovecii remain uncertain. We conducted a cross-sectional study of 126 San Francisco General Hospital staff in clinical (n = 103) and nonclinical (n = 23) occupations to assess whether occupational exposure was associated with immune responses to P. jirovecii. We examined antibody levels by ELISA for 3 overlapping fragments that span the P. jirovecii major surface glycoprotein (Msg): MsgA, MsgB, and MsgC1. Clinical occupation participants had higher geometric mean antibody levels to MsgC1 than did nonclinical occupation participants (21.1 vs. 8.2, p = 0.004); clinical occupation was an independent predictor of higher MsgC1 antibody levels (parameter estimate = 0.89, 95% confidence interval 0.29-1.48, p = 0.003). In contrast, occupation was not significantly associated with antibody responses to either MsgA or MsgB. Healthcare workers may have occupational exposure to P. jirovecii. Humans may be a reservoir for P. jirovecii and may transmit it from person to person. Humans may be a reservoir for this pathogen and transmit it from person to person. The reservoir and mode of transmission of Pneumocystis jirovecii remain uncertain. We conducted a cross-sectional study of 126 San Francisco General Hospital staff in clinical (n = 103) and nonclinical (n = 23) occupations to assess whether occupational exposure was associated with immune responses to P. jirovecii. We examined antibody levels by ELISA for 3 overlapping fragments that span the P. jirovecii major surface glycoprotein (Msg): MsgA, MsgB, and MsgC1. Clinical occupation participants had higher geometric mean antibody levels to MsgC1 than did nonclinical occupation participants (21.1 vs. 8.2, p = 0.004); clinical occupation was an independent predictor of higher MsgC1 antibody levels (parameter estimate = 0.89, 95% confidence interval 0.29–1.48, p = 0.003). In contrast, occupation was not significantly associated with antibody responses to either MsgA or MsgB. Healthcare workers may have occupational exposure to P. jirovecii. Humans may be a reservoir for P. jirovecii and may transmit it from person to person.
Audience	Professional Academic
Author	Tipirneni, Renuka Roth, Brenna M. Walzer, Peter D. Daly, Kieran R. Jarlsberg, Leah G. Koch, Judy V. Swartzman, Alexandra Huang, Laurence
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Snippet	The reservoir and mode of transmission of Pneumocystis jirovecii remain uncertain. We conducted a cross-sectional study of 126 San Francisco General Hospital... Humans may be a reservoir for this pathogen and transmit it from person to person. The reservoir and mode of transmission of Pneumocystis jirovecii remain...
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SubjectTerms	Adult Aged Aged, 80 and over antibodies Antibodies, Fungal - immunology Antiviral agents Causes of Cross-Sectional Studies Drug therapy Female fungal Fungal Proteins - immunology Health aspects Health Personnel HIV/AIDS and other retroviruses Humans Immune response Male Middle Aged Occupational Exposure opportunistic infections Pneumocystis Pneumocystis carinii - immunology Pneumocystis carinii pneumonia Pneumocystis Infections - epidemiology Pneumocystis Infections - immunology Prevention Surveys and Questionnaires Young Adult
Title	Healthcare Worker Occupation and Immune Response to Pneumocystis jirovecii
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