Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

Chromatin-based functional genomic analyses and genomewide association studies (GWASs) together implicate enhancers as critical elements influencing gene expression and risk for common diseases. Here, we performed systematic chromatin and transcriptome profiling in human pancreatic islets. Integrate...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 110; číslo 44; s. 17921
Hlavní autori:	Parker, Stephen C J, Stitzel, Michael L, Taylor, D Leland, Orozco, Jose Miguel, Erdos, Michael R, Akiyama, Jennifer A, van Bueren, Kelly Lammerts, Chines, Peter S, Narisu, Narisu, Black, Brian L, Visel, Axel, Pennacchio, Len A, Collins, Francis S
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 29.10.2013
Predmet:	Animals Cell Differentiation - physiology Chromatin - physiology Chromatin Immunoprecipitation Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - physiopathology Enhancer Elements, Genetic - genetics Enhancer Elements, Genetic - physiology Epigenomics - methods Gene Expression Profiling Gene Expression Regulation - genetics Gene Expression Regulation - physiology Genome-Wide Association Study High-Throughput Nucleotide Sequencing Humans Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - physiology Luciferases Mice Mice, Transgenic
ISSN:	1091-6490, 1091-6490
On-line prístup:	Zistit podrobnosti o prístupe
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