CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation

Recruitment of monocytic myeloid-derived suppressor cells (MDSCs) and differentiation of tumor-associated macrophages (TAMs) are the major factors contributing to tumor progression and metastasis. We demonstrated that differentiation of TAMs in tumor site from monocytic precursors was controlled by...

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Vol. 44; no. 2; pp. 303 - 315
Main Authors:	Kumar, Vinit, Cheng, Pingyan, Condamine, Thomas, Mony, Sridevi, Languino, Lucia R, McCaffrey, Judith C, Hockstein, Neil, Guarino, Michael, Masters, Gregory, Penman, Emily, Denstman, Fred, Xu, Xiaowei, Altieri, Dario C, Du, Hong, Yan, Cong, Gabrilovich, Dmitry I
Format:	Journal Article
Language:	English
Published:	United States 16.02.2016
Subjects:	Animals Cell Differentiation Cell Movement Cells, Cultured Dimerization Female Hypoxia - immunology Leukocyte Common Antigens - genetics Leukocyte Common Antigens - metabolism Macrophages - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Myeloid Cells - immunology Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Sialic Acids - metabolism STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Tumor Microenvironment
ISSN:	1097-4180
Online Access:	Get more information
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