Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis

Infections caused by antibiotic-resistant bacteria are a rising public health threat and make the identification of new antibiotics a priority. From a cell-based screen for bactericidal compounds against Mycobacterium tuberculosis under nutrient-deprivation conditions we identified auranofin, an ora...

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Vydáno v:	Proceedings of the National Academy of Sciences - PNAS Ročník 112; číslo 14; s. 4453
Hlavní autoři:	Harbut, Michael B, Vilchèze, Catherine, Luo, Xiaozhou, Hensler, Mary E, Guo, Hui, Yang, Baiyuan, Chatterjee, Arnab K, Nizet, Victor, Jacobs, Jr, William R, Schultz, Peter G, Wang, Feng
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 07.04.2015
Témata:	Animals Anti-Bacterial Agents - chemistry Auranofin - chemistry Bacillus subtilis - drug effects Bacterial Proteins - chemistry Dose-Response Relationship, Drug Enterococcus faecium - drug effects Female Gene Deletion Glutathione - chemistry Homeostasis Mice Microbial Sensitivity Tests Mycobacterium tuberculosis - drug effects Oxidation-Reduction Oxidative Stress Staphylococcus aureus - drug effects Stem Cells Sulfhydryl Compounds - chemistry Thioredoxin-Disulfide Reductase - chemistry auranofin Gram-positive MRSA tuberculosis
ISSN:	1091-6490, 1091-6490
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