Genome transplantation in bacteria: changing one species to another

As a step toward propagation of synthetic genomes, we completely replaced the genome of a bacterial cell with one from another species by transplanting a whole genome as naked DNA. Intact genomic DNA from Mycoplasma mycoides large colony (LC), virtually free of protein, was transplanted into Mycopla...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 317; no. 5838; p. 632
Main Authors:	Lartigue, Carole, Glass, John I, Alperovich, Nina, Pieper, Rembert, Parmar, Prashanth P, Hutchison, 3rd, Clyde A, Smith, Hamilton O, Venter, J Craig
Format:	Journal Article
Language:	English
Published:	United States 03.08.2007
Subjects:	Acetate Kinase - chemistry Acetate Kinase - genetics Amino Acid Sequence DNA, Bacterial - genetics DNA, Bacterial - isolation & purification Genome, Bacterial Genotype Molecular Sequence Data Mycoplasma - chemistry Mycoplasma - genetics Mycoplasma mycoides - chemistry Mycoplasma mycoides - genetics Phenotype Polyethylene Glycols Proteome - analysis Recombination, Genetic Sequence Analysis, DNA Transformation, Bacterial
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
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