Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides
Despite increasing evidence supporting the neuroinflammatory theory of depression, little is known about cerebral macrophages in individuals suffering from major depression. In the present study, we investigated the morphology and distribution of cells immunostained for the macrophage-specific marke...
Uložené v:
| Vydané v: | Brain, behavior, and immunity Ročník 42; s. 50 - 59 |
|---|---|
| Hlavní autori: | , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
Netherlands
Elsevier Inc
01.11.2014
|
| Predmet: | |
| ISSN: | 0889-1591, 1090-2139, 1090-2139 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Despite increasing evidence supporting the neuroinflammatory theory of depression, little is known about cerebral macrophages in individuals suffering from major depression. In the present study, we investigated the morphology and distribution of cells immunostained for the macrophage-specific marker ionized calcium binding adaptor molecule 1 (IBA1) in the dorsal anterior cingulate cortex (dACC) white matter of middle-aged depressed suicides and matched non-psychiatric controls. This region is known for its implication in mood disorders, and its white matter compartment was previously found to display hypertrophic astrocytes in depressed suicides. Distributions of IBA1-immunoreactive (IBA-IR) microglial phenotypes were assessed using stereology and cell morphometry, and blood vessels were characterized as being intimately associated with either a high or a low density of IBA1-IR amoeboid-like cells. Total densities of IBA1-IR microglia did not differ between depressed suicides and controls. However, a finer analysis examining relative proportions of microglial phenotypes revealed that the ratio of primed over ramified (“resting”) microglia was significantly increased in depressed suicides. Strikingly, the proportion of blood vessels surrounded by a high density of macrophages was more than twice higher in depressed suicides than in controls, and this difference was strongly significant. Consistent with these observations, gene expression of IBA1 and MCP-1, a chemokine involved in the recruitment of circulating monocytes, was significantly upregulated in depressed suicides. Furthermore, mRNA for CD45, a marker enriched in perivascular macrophages, was also significantly increased in samples from depressed suicides. An increase compared to controls was also observed in the proportion of blood vessels surrounded by a high density of CD45-IR cells, but this difference did not reach significance. These histological and molecular data suggest the recruitment of monocytes in dACC white matter of depressed suicides, although it cannot be excluded that other types of macrophages (including microglia) account for the observed accumulation of macrophages closely associated with blood vessels. Altogether, these findings suggest that the previously reported depression- and suicide-associated increases in circulating pro-inflammatory cytokines may be associated with low-grade cerebral neuroinflammation involving the recruitment of circulating monocytes. |
|---|---|
| AbstractList | Despite increasing evidence supporting the neuroinflammatory theory of depression, little is known about cerebral macrophages in individuals suffering from major depression. In the present study, we investigated the morphology and distribution of cells immunostained for the macrophage-specific marker ionized calcium binding adaptor molecule 1 (IBA1) in the dorsal anterior cingulate cortex (dACC) white matter of middle-aged depressed suicides and matched non-psychiatric controls. This region is known for its implication in mood disorders, and its white matter compartment was previously found to display hypertrophic astrocytes in depressed suicides. Distributions of IBA1-immunoreactive (IBA-IR) microglial phenotypes were assessed using stereology and cell morphometry, and blood vessels were characterized as being intimately associated with either a high or a low density of IBA1-IR amoeboid-like cells. Total densities of IBA1-IR microglia did not differ between depressed suicides and controls. However, a finer analysis examining relative proportions of microglial phenotypes revealed that the ratio of primed over ramified ("resting") microglia was significantly increased in depressed suicides. Strikingly, the proportion of blood vessels surrounded by a high density of macrophages was more than twice higher in depressed suicides than in controls, and this difference was strongly significant. Consistent with these observations, gene expression of IBA1 and MCP-1, a chemokine involved in the recruitment of circulating monocytes, was significantly upregulated in depressed suicides. Furthermore, mRNA for CD45, a marker enriched in perivascular macrophages, was also significantly increased in samples from depressed suicides. An increase compared to controls was also observed in the proportion of blood vessels surrounded by a high density of CD45-IR cells, but this difference did not reach significance. These histological and molecular data suggest the recruitment of monocytes in dACC white matter of depressed suicides, although it cannot be excluded that other types of macrophages (including microglia) account for the observed accumulation of macrophages closely associated with blood vessels. Altogether, these findings suggest that the previously reported depression- and suicide-associated increases in circulating pro-inflammatory cytokines may be associated with low-grade cerebral neuroinflammation involving the recruitment of circulating monocytes. Despite increasing evidence supporting the neuroinflammatory theory of depression, little is known about cerebral macrophages in individuals suffering from major depression. In the present study, we investigated the morphology and distribution of cells immunostained for the macrophage-specific marker ionized calcium binding adaptor molecule 1 (IBA1) in the dorsal anterior cingulate cortex (dACC) white matter of middle-aged depressed suicides and matched non-psychiatric controls. This region is known for its implication in mood disorders, and its white matter compartment was previously found to display hypertrophic astrocytes in depressed suicides. Distributions of IBA1-immunoreactive (IBA-IR) microglial phenotypes were assessed using stereology and cell morphometry, and blood vessels were characterized as being intimately associated with either a high or a low density of IBA1-IR amoeboid-like cells. Total densities of IBA1-IR microglia did not differ between depressed suicides and controls. However, a finer analysis examining relative proportions of microglial phenotypes revealed that the ratio of primed over ramified ("resting") microglia was significantly increased in depressed suicides. Strikingly, the proportion of blood vessels surrounded by a high density of macrophages was more than twice higher in depressed suicides than in controls, and this difference was strongly significant. Consistent with these observations, gene expression of IBA1 and MCP-1, a chemokine involved in the recruitment of circulating monocytes, was significantly upregulated in depressed suicides. Furthermore, mRNA for CD45, a marker enriched in perivascular macrophages, was also significantly increased in samples from depressed suicides. An increase compared to controls was also observed in the proportion of blood vessels surrounded by a high density of CD45-IR cells, but this difference did not reach significance. These histological and molecular data suggest the recruitment of monocytes in dACC white matter of depressed suicides, although it cannot be excluded that other types of macrophages (including microglia) account for the observed accumulation of macrophages closely associated with blood vessels. Altogether, these findings suggest that the previously reported depression- and suicide-associated increases in circulating pro-inflammatory cytokines may be associated with low-grade cerebral neuroinflammation involving the recruitment of circulating monocytes.Despite increasing evidence supporting the neuroinflammatory theory of depression, little is known about cerebral macrophages in individuals suffering from major depression. In the present study, we investigated the morphology and distribution of cells immunostained for the macrophage-specific marker ionized calcium binding adaptor molecule 1 (IBA1) in the dorsal anterior cingulate cortex (dACC) white matter of middle-aged depressed suicides and matched non-psychiatric controls. This region is known for its implication in mood disorders, and its white matter compartment was previously found to display hypertrophic astrocytes in depressed suicides. Distributions of IBA1-immunoreactive (IBA-IR) microglial phenotypes were assessed using stereology and cell morphometry, and blood vessels were characterized as being intimately associated with either a high or a low density of IBA1-IR amoeboid-like cells. Total densities of IBA1-IR microglia did not differ between depressed suicides and controls. However, a finer analysis examining relative proportions of microglial phenotypes revealed that the ratio of primed over ramified ("resting") microglia was significantly increased in depressed suicides. Strikingly, the proportion of blood vessels surrounded by a high density of macrophages was more than twice higher in depressed suicides than in controls, and this difference was strongly significant. Consistent with these observations, gene expression of IBA1 and MCP-1, a chemokine involved in the recruitment of circulating monocytes, was significantly upregulated in depressed suicides. Furthermore, mRNA for CD45, a marker enriched in perivascular macrophages, was also significantly increased in samples from depressed suicides. An increase compared to controls was also observed in the proportion of blood vessels surrounded by a high density of CD45-IR cells, but this difference did not reach significance. These histological and molecular data suggest the recruitment of monocytes in dACC white matter of depressed suicides, although it cannot be excluded that other types of macrophages (including microglia) account for the observed accumulation of macrophages closely associated with blood vessels. Altogether, these findings suggest that the previously reported depression- and suicide-associated increases in circulating pro-inflammatory cytokines may be associated with low-grade cerebral neuroinflammation involving the recruitment of circulating monocytes. Abstract Despite increasing evidence supporting the neuroinflammatory theory of depression, little is known about cerebral macrophages in individuals suffering from major depression. In the present study, we investigated the morphology and distribution of cells immunostained for the macrophage-specific marker ionized calcium binding adaptor molecule 1 (IBA1) in the dorsal anterior cingulate cortex (dACC) white matter of middle-aged depressed suicides and matched non-psychiatric controls. This region is known for its implication in mood disorders, and its white matter compartment was previously found to display hypertrophic astrocytes in depressed suicides. Distributions of IBA1-immunoreactive (IBA-IR) microglial phenotypes were assessed using stereology and cell morphometry, and blood vessels were characterized as being intimately associated with either a high or a low density of IBA1-IR amoeboid-like cells. Total densities of IBA1-IR microglia did not differ between depressed suicides and controls. However, a finer analysis examining relative proportions of microglial phenotypes revealed that the ratio of primed over ramified (“resting”) microglia was significantly increased in depressed suicides. Strikingly, the proportion of blood vessels surrounded by a high density of macrophages was more than twice higher in depressed suicides than in controls, and this difference was strongly significant. Consistent with these observations, gene expression of IBA1 and MCP-1, a chemokine involved in the recruitment of circulating monocytes, was significantly upregulated in depressed suicides. Furthermore, mRNA for CD45, a marker enriched in perivascular macrophages, was also significantly increased in samples from depressed suicides. An increase compared to controls was also observed in the proportion of blood vessels surrounded by a high density of CD45-IR cells, but this difference did not reach significance. These histological and molecular data suggest the recruitment of monocytes in dACC white matter of depressed suicides, although it cannot be excluded that other types of macrophages (including microglia) account for the observed accumulation of macrophages closely associated with blood vessels. Altogether, these findings suggest that the previously reported depression- and suicide-associated increases in circulating pro-inflammatory cytokines may be associated with low-grade cerebral neuroinflammation involving the recruitment of circulating monocytes. |
| Author | Mechawar, Naguib Torres-Platas, Susana G. Chen, Gary Gang Turecki, Gustavo Cruceanu, Cristiana |
| Author_xml | – sequence: 1 givenname: Susana G. surname: Torres-Platas fullname: Torres-Platas, Susana G. organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, Québec H4H 1R3, Canada – sequence: 2 givenname: Cristiana surname: Cruceanu fullname: Cruceanu, Cristiana organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, Québec H4H 1R3, Canada – sequence: 3 givenname: Gary Gang surname: Chen fullname: Chen, Gary Gang organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, Québec H4H 1R3, Canada – sequence: 4 givenname: Gustavo surname: Turecki fullname: Turecki, Gustavo organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, Québec H4H 1R3, Canada – sequence: 5 givenname: Naguib surname: Mechawar fullname: Mechawar, Naguib email: naguib.mechawar@mcgill.ca organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, Québec H4H 1R3, Canada |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24858659$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFklFrFDEUhYNU7Lb6A3yRPPqy22QymZkgCFKqFgo-qM8hk9zsZp3JrEmm0n_gz_YO274UbBnIwM35TsI5OSMncYpAyFvONpzx5mK_6fuwqRivN0xuGGtfkBVniq0rLtQJWbGuU2suFT8lZznvGWNS8O4VOa3qTnaNVCvy9-o2OIgWqJ8SDdEmMBkcHYNN03YIZqCHFMYQt9REHBscH3ZmCzSBTXMoI8SCHC07oG5KGQETC6SAdhaxeTAF6J9dwHU0BXfo5KmDQ4K8HJTnYPEG-TV56c2Q4c39_5z8_Hz14_Lr-ubbl-vLTzdrKxUr61rU1jWeW9F2XvhKGs6hNjhwTd83XVMJ5lRfe-d8a4VsRSO9VF3tjeylacU5eX_0PaTp9wy56DFkC8NgIkxz1rypW8bE8j0vrZRqMFGB0nf30rkfweklM5Pu9EPQKGiPAswv5wRe21BMCVMsyYRBc6aXSvVeY6V6qVQzqbFSJPkj8sH8KebDkQFM8jZA0tmGpWUXsLai3RSepD8-ou0QYrBm-AV3kPfTnCJWpLnOlWb6-_LMllfGa8Y4RoIG6v8Gzxz-D3sv4zM |
| CitedBy_id | crossref_primary_10_1007_s12035_020_01961_y crossref_primary_10_1016_j_pharmthera_2020_107480 crossref_primary_10_1111_pcn_13286 crossref_primary_10_1007_s11920_024_01526_z crossref_primary_10_3389_fnins_2019_01196 crossref_primary_10_1038_s41380_018_0241_z crossref_primary_10_1111_ejn_14547 crossref_primary_10_1016_j_neulet_2019_134369 crossref_primary_10_1016_j_psyneuen_2015_10_008 crossref_primary_10_1016_j_bbi_2022_07_006 crossref_primary_10_1016_j_bbi_2024_04_025 crossref_primary_10_3390_ijms25137144 crossref_primary_10_1016_j_bbi_2023_10_011 crossref_primary_10_1016_j_bbr_2019_111975 crossref_primary_10_2174_0929867326666190712091515 crossref_primary_10_1016_j_bbi_2018_06_010 crossref_primary_10_1016_j_neubiorev_2022_104606 crossref_primary_10_1016_j_bbi_2019_04_004 crossref_primary_10_1016_j_euroneuro_2020_03_004 crossref_primary_10_1080_15622975_2021_1939154 crossref_primary_10_1007_s12035_024_04205_5 crossref_primary_10_1155_2024_1089236 crossref_primary_10_1186_s12868_018_0460_x crossref_primary_10_1016_j_bbi_2024_08_048 crossref_primary_10_1111_jcpp_13961 crossref_primary_10_3389_fphar_2023_974905 crossref_primary_10_1111_jnc_16083 crossref_primary_10_1186_s12991_025_00571_z crossref_primary_10_1523_JNEUROSCI_2568_17_2018 crossref_primary_10_1073_pnas_1911816117 crossref_primary_10_1523_JNEUROSCI_1673_18_2018 crossref_primary_10_3390_life10060082 crossref_primary_10_1016_j_biopsych_2023_04_020 crossref_primary_10_1002_brb3_1028 crossref_primary_10_1002_brb3_70818 crossref_primary_10_61958_NMRT4411 crossref_primary_10_1016_j_biopha_2018_07_040 crossref_primary_10_1016_j_scitotenv_2024_178085 crossref_primary_10_1007_s11064_020_03225_6 crossref_primary_10_3389_fncel_2015_00521 crossref_primary_10_1016_j_mcp_2019_101470 crossref_primary_10_3389_fneur_2019_00345 crossref_primary_10_1176_appi_ajp_20250289 crossref_primary_10_1007_s00787_024_02579_4 crossref_primary_10_1111_bph_14569 crossref_primary_10_1038_s41398_023_02464_9 crossref_primary_10_1016_j_bbi_2020_04_013 crossref_primary_10_3389_fpsyt_2022_893097 crossref_primary_10_3389_fpsyt_2018_00434 crossref_primary_10_1159_000476035 crossref_primary_10_1007_s12035_018_1161_2 crossref_primary_10_1016_j_bbi_2019_07_001 crossref_primary_10_1016_j_bbi_2017_01_019 crossref_primary_10_1038_nn_4113 crossref_primary_10_1038_s41380_024_02751_x crossref_primary_10_1016_j_neulet_2023_137350 crossref_primary_10_1016_j_bbr_2023_114839 crossref_primary_10_1007_s12035_023_03370_3 crossref_primary_10_1016_j_jpsychires_2024_11_044 crossref_primary_10_1124_jpet_123_001759 crossref_primary_10_1111_acps_12656 crossref_primary_10_3390_biom12081134 crossref_primary_10_3390_ijms25020865 crossref_primary_10_1371_journal_pone_0187631 crossref_primary_10_1155_2020_2972968 crossref_primary_10_1016_j_immuni_2020_12_016 crossref_primary_10_1186_s12865_024_00653_9 crossref_primary_10_1038_s41380_021_01338_0 crossref_primary_10_3390_cells13020177 crossref_primary_10_1016_j_bbih_2021_100383 crossref_primary_10_1016_j_jneuroim_2025_578587 crossref_primary_10_1016_j_jare_2024_07_015 crossref_primary_10_5498_wjp_v11_i12_1191 crossref_primary_10_1038_nrn3839 crossref_primary_10_1038_s41386_025_02162_8 crossref_primary_10_3390_nu10050548 crossref_primary_10_1016_j_pneurobio_2018_09_002 crossref_primary_10_1093_jnen_nly103 crossref_primary_10_1016_j_neuropharm_2021_108621 crossref_primary_10_1038_s41398_021_01571_9 crossref_primary_10_1111_jnc_16098 crossref_primary_10_1016_j_bcp_2024_116672 crossref_primary_10_1016_j_biopsych_2015_07_010 crossref_primary_10_1016_j_bbi_2024_12_013 crossref_primary_10_3390_jpm13071078 crossref_primary_10_3390_metabo13030455 crossref_primary_10_3390_ijms26178697 crossref_primary_10_1016_j_bbi_2024_04_030 crossref_primary_10_1124_pharmrev_120_000043 crossref_primary_10_1016_j_neuroscience_2015_05_018 crossref_primary_10_3390_ijms20153723 crossref_primary_10_1016_j_bbi_2023_02_021 crossref_primary_10_1186_s12888_015_0691_7 crossref_primary_10_3389_fpsyt_2017_00046 crossref_primary_10_3390_ijms22168525 crossref_primary_10_1016_j_bbih_2024_100797 crossref_primary_10_1016_j_neuron_2022_10_020 crossref_primary_10_3390_cells12111521 crossref_primary_10_1055_s_0045_1804893 crossref_primary_10_3390_psychiatryint6030084 crossref_primary_10_1038_tp_2016_212 crossref_primary_10_3389_fnins_2014_00447 crossref_primary_10_1080_14737175_2018_1407242 crossref_primary_10_1038_s41398_022_01794_4 crossref_primary_10_1016_j_jpsychires_2020_02_027 crossref_primary_10_1053_j_gastro_2017_08_011 crossref_primary_10_1038_npp_2016_116 crossref_primary_10_1016_j_bbih_2025_101010 crossref_primary_10_4103_bc_bc_88_24 crossref_primary_10_1016_j_bpsc_2020_04_008 crossref_primary_10_1016_j_biopsych_2022_11_003 crossref_primary_10_1007_s12035_017_0680_6 crossref_primary_10_3389_fimmu_2022_845678 crossref_primary_10_3389_fpsyt_2024_1321354 crossref_primary_10_3389_fnint_2021_632249 crossref_primary_10_1016_j_neubiorev_2017_01_046 crossref_primary_10_12923_2353_8627_2024_0016 crossref_primary_10_1038_s41598_020_57967_y crossref_primary_10_3389_fpsyt_2020_00122 crossref_primary_10_1016_j_bbi_2018_07_012 crossref_primary_10_1016_j_jad_2024_04_022 crossref_primary_10_3389_fimmu_2016_00544 crossref_primary_10_1192_apt_bp_114_012872 crossref_primary_10_1016_j_bbih_2021_100320 crossref_primary_10_1111_jnc_13607 crossref_primary_10_1016_j_bbrc_2021_12_037 crossref_primary_10_1016_j_pnpbp_2021_110343 crossref_primary_10_1016_j_biopha_2023_114852 crossref_primary_10_3389_fimmu_2024_1479471 crossref_primary_10_1016_j_brainresbull_2022_10_021 crossref_primary_10_1051_bioconf_20248601039 crossref_primary_10_4103_NRR_NRR_D_23_01878 crossref_primary_10_3109_15622975_2015_1054879 crossref_primary_10_1016_j_biopsych_2021_11_012 crossref_primary_10_1016_j_bpsc_2020_12_017 crossref_primary_10_1016_j_bbih_2025_101002 crossref_primary_10_3389_fpsyt_2015_00138 crossref_primary_10_1038_npp_2016_102 crossref_primary_10_1007_s12035_023_03810_0 crossref_primary_10_1016_j_jneuroim_2025_578728 crossref_primary_10_1016_j_neuroscience_2015_02_028 crossref_primary_10_1038_s41380_025_03139_1 crossref_primary_10_1016_j_pnpbp_2019_109648 crossref_primary_10_1016_j_neubiorev_2017_09_014 crossref_primary_10_1016_j_bbi_2021_12_003 crossref_primary_10_3389_fpsyt_2018_00471 crossref_primary_10_2174_0113816128333916241003180018 crossref_primary_10_1038_s41380_023_02162_4 crossref_primary_10_1016_j_bbi_2016_03_025 crossref_primary_10_3389_fnbeh_2025_1598178 crossref_primary_10_1016_j_bbi_2025_04_005 crossref_primary_10_1038_mp_2017_205 crossref_primary_10_1016_j_neuropharm_2023_109693 crossref_primary_10_1097_gscm_0000000000000031 crossref_primary_10_3389_fphar_2024_1476558 crossref_primary_10_1016_j_psyneuen_2024_107268 crossref_primary_10_1016_j_bbi_2020_11_033 crossref_primary_10_1016_j_neuron_2021_06_012 crossref_primary_10_3390_biomedicines9020189 crossref_primary_10_1038_s41583_021_00513_0 crossref_primary_10_3389_fphar_2019_00286 crossref_primary_10_1002_glia_23962 crossref_primary_10_1016_j_bbih_2021_100344 crossref_primary_10_1038_nri_2015_5 crossref_primary_10_1038_s41380_025_03082_1 crossref_primary_10_1515_tnsci_2022_0236 crossref_primary_10_1016_j_psyneuen_2020_104843 crossref_primary_10_3390_ijms241612634 crossref_primary_10_1016_j_phrs_2021_105957 crossref_primary_10_1007_s12035_021_02672_8 crossref_primary_10_3389_fnins_2018_00547 crossref_primary_10_3389_fpsyt_2020_00718 crossref_primary_10_1016_j_brainresbull_2022_04_013 crossref_primary_10_1016_j_ynpai_2020_100045 crossref_primary_10_1016_j_neuropharm_2017_01_031 crossref_primary_10_3928_00485713_20150501_05 crossref_primary_10_1016_j_pharmthera_2025_108825 crossref_primary_10_1016_j_bbih_2020_100038 crossref_primary_10_1038_s41380_019_0433_1 crossref_primary_10_1038_s41398_022_02297_y crossref_primary_10_1016_j_bbr_2020_112557 crossref_primary_10_1159_000494761 crossref_primary_10_1016_j_bbih_2020_100111 crossref_primary_10_1111_ejn_15239 crossref_primary_10_3389_fneur_2016_00005 crossref_primary_10_3389_fncel_2022_1066794 crossref_primary_10_1002_glia_24123 crossref_primary_10_1016_j_bbi_2024_09_013 crossref_primary_10_3389_fncel_2022_839396 crossref_primary_10_1007_s11064_024_04111_1 crossref_primary_10_1038_s41590_022_01321_z crossref_primary_10_1016_j_jad_2021_06_001 crossref_primary_10_3390_ijms25115750 crossref_primary_10_1016_j_neubiorev_2021_01_025 crossref_primary_10_1016_j_bbi_2019_06_015 crossref_primary_10_3389_fneur_2019_00515 crossref_primary_10_1038_s41386_019_0471_z crossref_primary_10_3389_fncel_2015_00476 crossref_primary_10_1016_j_bbrc_2021_12_074 crossref_primary_10_1080_07853890_2023_2249015 crossref_primary_10_1016_j_bbi_2020_10_013 crossref_primary_10_1038_mp_2016_130 crossref_primary_10_1016_j_phrs_2023_106833 crossref_primary_10_1016_j_bbi_2021_12_019 crossref_primary_10_1111_gbb_12475 crossref_primary_10_1016_j_biopsych_2020_12_025 crossref_primary_10_1016_j_brainresbull_2016_03_012 crossref_primary_10_1016_j_psychres_2024_116141 crossref_primary_10_1038_s41386_018_0064_2 crossref_primary_10_1007_s00429_021_02321_9 crossref_primary_10_1016_j_bbi_2019_10_016 crossref_primary_10_1016_j_phymed_2024_156178 crossref_primary_10_1016_j_biopsych_2025_06_012 crossref_primary_10_1111_bpa_12908 crossref_primary_10_1002_glia_23143 crossref_primary_10_1016_j_ibneur_2022_09_001 crossref_primary_10_1186_s12974_018_1294_2 crossref_primary_10_1017_neu_2023_11 crossref_primary_10_1124_jpet_123_001823 crossref_primary_10_1016_j_neuropharm_2018_04_013 crossref_primary_10_1186_s12974_022_02492_0 crossref_primary_10_3389_fncel_2019_00031 crossref_primary_10_1038_npp_2016_143 crossref_primary_10_1007_s00406_020_01107_0 crossref_primary_10_1016_j_bbi_2015_10_003 crossref_primary_10_1016_j_intimp_2023_110903 crossref_primary_10_1016_j_pharmthera_2024_108624 crossref_primary_10_3389_fphar_2022_991243 crossref_primary_10_1016_j_coph_2016_06_008 crossref_primary_10_1016_j_ajp_2019_101894 crossref_primary_10_1016_j_cobeha_2019_01_001 crossref_primary_10_1016_j_nicl_2021_102926 crossref_primary_10_1016_j_pbb_2025_174097 crossref_primary_10_1016_j_bbi_2019_09_016 crossref_primary_10_1016_j_bbi_2023_07_023 crossref_primary_10_1038_npp_2016_90 crossref_primary_10_1038_s41598_025_85431_2 crossref_primary_10_1016_j_jpsychires_2025_06_024 crossref_primary_10_1016_j_pbb_2025_174099 crossref_primary_10_1111_acps_13351 crossref_primary_10_1007_s12640_020_00235_8 crossref_primary_10_1016_j_bbi_2018_07_006 crossref_primary_10_3389_fimmu_2023_1320271 crossref_primary_10_5498_wjp_v15_i9_107726 crossref_primary_10_1016_j_bbi_2021_01_033 crossref_primary_10_1038_s41582_025_01116_4 crossref_primary_10_1007_s12035_024_04575_w crossref_primary_10_1016_j_bbi_2017_10_016 crossref_primary_10_1124_jpet_120_266163 crossref_primary_10_1007_s00406_021_01232_4 crossref_primary_10_1038_s41386_018_0124_7 crossref_primary_10_1007_s11920_018_0978_8 crossref_primary_10_1016_j_neuint_2024_105723 crossref_primary_10_1016_j_biopsych_2017_08_005 crossref_primary_10_1016_j_mcna_2022_09_001 crossref_primary_10_3389_fnana_2015_00023 crossref_primary_10_1016_j_bbih_2020_100124 crossref_primary_10_3389_fninf_2022_1040008 crossref_primary_10_1016_j_bbr_2019_112191 crossref_primary_10_1038_nrn_2016_69 crossref_primary_10_3389_fnmol_2022_981442 crossref_primary_10_5498_wjp_v15_i2_98484 crossref_primary_10_1080_01616412_2025_2520017 crossref_primary_10_3389_fmolb_2022_887678 crossref_primary_10_1111_bph_14074 crossref_primary_10_1016_j_bbi_2014_07_009 crossref_primary_10_1016_j_jad_2021_08_098 crossref_primary_10_1016_j_heliyon_2024_e28960 crossref_primary_10_3389_fimmu_2018_02325 crossref_primary_10_1016_j_bbi_2025_01_028 crossref_primary_10_3233_NIB_160110 crossref_primary_10_1016_j_expneurol_2023_114426 crossref_primary_10_3389_fncel_2021_647378 crossref_primary_10_1093_ijnp_pyw071 crossref_primary_10_1016_j_bbi_2015_02_004 crossref_primary_10_1016_j_jpsychires_2016_02_003 crossref_primary_10_3389_fncel_2018_00306 crossref_primary_10_1146_annurev_immunol_051116_052358 crossref_primary_10_1016_j_jpsychires_2019_10_008 crossref_primary_10_3389_fimmu_2020_01818 crossref_primary_10_1016_j_tins_2021_09_005 crossref_primary_10_1002_dneu_22652 crossref_primary_10_1016_j_nbd_2023_106005 crossref_primary_10_3390_ph14010065 crossref_primary_10_1038_mp_2017_141 crossref_primary_10_3390_ijms26072940 crossref_primary_10_1038_s41398_021_01742_8 crossref_primary_10_1016_j_intimp_2024_113011 crossref_primary_10_1097_HRP_0000000000000325 crossref_primary_10_1371_journal_pone_0269140 crossref_primary_10_2217_imt_2017_0056 crossref_primary_10_1038_npp_2016_199 crossref_primary_10_1016_j_physbeh_2016_01_002 crossref_primary_10_1038_s41380_024_02420_z crossref_primary_10_1038_s41398_020_00992_2 crossref_primary_10_1038_s41398_020_0768_z crossref_primary_10_3389_fnmol_2017_00421 crossref_primary_10_3389_fpsyt_2022_871997 crossref_primary_10_1016_j_bbr_2020_112640 crossref_primary_10_1017_S0031182022000166 crossref_primary_10_1038_s41398_019_0556_9 crossref_primary_10_1016_j_bbih_2023_100684 crossref_primary_10_1016_j_pnpbp_2017_11_017 crossref_primary_10_1016_j_bbi_2020_03_018 crossref_primary_10_1007_s12035_020_02144_5 crossref_primary_10_1038_s41467_018_04883_5 crossref_primary_10_1093_procel_pwad020 crossref_primary_10_1007_s12035_022_03199_2 crossref_primary_10_1155_2023_3199988 crossref_primary_10_1016_j_expneurol_2022_114060 crossref_primary_10_1007_s11481_025_10232_3 crossref_primary_10_1038_s41380_020_00896_z crossref_primary_10_1016_j_jad_2020_10_024 crossref_primary_10_1503_jpn_170192 crossref_primary_10_3390_ijerph17072393 crossref_primary_10_1016_j_neubiorev_2017_08_023 crossref_primary_10_1016_j_jpsychires_2020_12_029 crossref_primary_10_3390_ph11030064 crossref_primary_10_1007_s00406_021_01334_z crossref_primary_10_1038_npp_2016_185 crossref_primary_10_3389_fncel_2018_00323 crossref_primary_10_1186_s12974_015_0416_3 crossref_primary_10_3389_fpsyt_2020_00781 crossref_primary_10_1007_s11920_016_0736_8 crossref_primary_10_1016_j_bbih_2022_100495 crossref_primary_10_1016_j_pnpbp_2024_111227 crossref_primary_10_1186_s12974_019_1632_z crossref_primary_10_3390_ijms26189250 crossref_primary_10_1017_S003329172200232X crossref_primary_10_1093_ijnp_pyw045 crossref_primary_10_1016_j_ejphar_2025_177884 crossref_primary_10_1016_j_pnpbp_2016_04_013 crossref_primary_10_1002_glia_24661 crossref_primary_10_1016_j_ejphar_2025_177525 crossref_primary_10_1016_j_tins_2015_08_001 crossref_primary_10_3389_fncel_2016_00144 crossref_primary_10_3389_fnins_2022_867357 crossref_primary_10_1016_j_bbi_2019_01_015 crossref_primary_10_3389_fncel_2024_1369951 crossref_primary_10_3389_fnmol_2018_00056 crossref_primary_10_1503_jpn_150226 crossref_primary_10_1016_j_mad_2021_111512 crossref_primary_10_1016_j_pnpbp_2017_01_007 crossref_primary_10_1007_s00406_021_01306_3 crossref_primary_10_1186_s12974_022_02648_y crossref_primary_10_1016_j_neuint_2021_104987 crossref_primary_10_1016_j_neuron_2022_01_033 crossref_primary_10_1002_cncr_31584 crossref_primary_10_1007_s00406_017_0774_1 crossref_primary_10_1016_j_bbi_2023_08_025 crossref_primary_10_1093_eurheartj_suaa119 crossref_primary_10_1007_s11427_020_1815_6 crossref_primary_10_3389_fpsyt_2024_1415505 crossref_primary_10_1016_j_bbih_2024_100843 crossref_primary_10_1016_j_neubiorev_2021_09_023 crossref_primary_10_1016_j_phrs_2022_106145 crossref_primary_10_1186_s41983_023_00705_8 crossref_primary_10_3389_fpsyt_2018_00761 crossref_primary_10_1016_j_bbi_2018_09_024 crossref_primary_10_1186_s13104_024_07078_y crossref_primary_10_1038_npp_2016_167 crossref_primary_10_1016_j_jagp_2023_06_001 crossref_primary_10_1016_S2215_0366_17_30101_3 crossref_primary_10_1038_tp_2017_31 crossref_primary_10_1016_j_drudis_2022_06_015 crossref_primary_10_1016_j_neuron_2020_06_002 crossref_primary_10_1016_j_ctrv_2016_11_004 crossref_primary_10_14336_AD_2024_0239 crossref_primary_10_18632_oncotarget_13551 crossref_primary_10_1523_JNEUROSCI_2394_15_2016 crossref_primary_10_1038_s41421_023_00588_2 crossref_primary_10_1016_j_psyneuen_2018_07_016 |
| Cites_doi | 10.1002/1098-1136(200103)33:3<256::AID-GLIA1024>3.0.CO;2-J 10.3109/09540261.2013.813442 10.1016/j.jad.2013.10.048 10.1007/s00401-009-0619-8 10.1016/0006-3223(95)00320-7 10.1017/S1092852900016734 10.1038/npp.2011.154 10.1016/0006-3223(95)00295-2 10.1002/glia.22394 10.1002/cne.903590310 10.1152/physrev.00011.2010 10.1017/S0033291703008146 10.1523/JNEUROSCI.3510-08.2008 10.1007/s11011-008-9118-1 10.1176/appi.ajp.162.11.2116 10.1007/s00213-002-1273-1 10.1016/j.biopsych.2009.09.033 10.1016/j.brainres.2004.03.064 10.1002/1097-4547(20010101)63:1<90::AID-JNR11>3.0.CO;2-9 10.1016/j.psyneuen.2012.02.003 10.1523/JNEUROSCI.1671-13.2013 10.1016/S0006-3223(03)00114-8 10.1159/000026485 10.1016/j.biopsych.2008.11.029 10.1111/j.1600-0447.2007.01128.x 10.1016/j.bbr.2011.03.060 10.1017/S1461145710001410 10.1016/j.jpsychires.2011.08.006 10.1016/j.jpsychires.2006.10.013 10.1038/nrn2297 10.1139/jpn.0937 10.1038/npp.2014.25 10.1002/glia.10149 10.1002/jnr.22402 10.1038/sj.mp.4002055 10.1038/tp.2012.34 10.1189/jlb.0303114 10.1002/da.22084 10.1016/j.biopsych.2005.03.033 10.1038/mp.2013.154 10.3389/fncel.2013.00003 10.1186/1742-2094-8-94 10.1038/npp.2012.248 10.1016/j.biopsych.2004.02.009 10.1186/1742-2094-11-12 10.1016/j.neuron.2009.11.032 |
| ContentType | Journal Article |
| Copyright | 2014 Elsevier Inc. Elsevier Inc. Copyright © 2014 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: 2014 Elsevier Inc. – notice: Elsevier Inc. – notice: Copyright © 2014 Elsevier Inc. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7QG 7T5 7TK H94 |
| DOI | 10.1016/j.bbi.2014.05.007 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Animal Behavior Abstracts Immunology Abstracts Neurosciences Abstracts AIDS and Cancer Research Abstracts |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AIDS and Cancer Research Abstracts Immunology Abstracts Neurosciences Abstracts Animal Behavior Abstracts |
| DatabaseTitleList | AIDS and Cancer Research Abstracts MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1090-2139 |
| EndPage | 59 |
| ExternalDocumentID | 24858659 10_1016_j_bbi_2014_05_007 S0889159114001299 1_s2_0_S0889159114001299 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 23N 4.4 457 4G. 53G 5GY 5RE 5VS 6J9 7-5 71M 8P~ 9JM 9JO AAAJQ AADFP AAEDT AAEDW AAGJA AAGUQ AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AATTM AAXKI AAXLA AAXUO AAYWO ABCQJ ABFNM ABFRF ABIVO ABJNI ABMAC ABOYX ABWVN ABXDB ACDAQ ACGFO ACGFS ACLOT ACRLP ACRPL ACVFH ACXNI ADBBV ADCNI ADEZE ADFGL ADMUD ADNMO AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AFFNX AFJKZ AFPUW AFRHN AFTJW AFXIZ AGEKW AGHFR AGQPQ AGUBO AGWIK AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CAG CJTIS COF CS3 DM4 DU5 EBS EFBJH EFKBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMG HMQ HVGLF HZ~ IHE J1W KOM L7B LG5 LUGTX LZ5 M2U M41 MO0 MOBAO N9A O-L O9- OAUVE OH0 OKEIE OU- OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SCC SDF SDG SDP SES SEW SIN SNS SPCBC SSB SSI SSN SSY SSZ T5K TN5 UAP UNMZH UPT WUQ XPP XSW Z5R ZGI ZMT ~G- ~HD ~S- AACTN AFCTW AFKWA AJOXV AMFUW RIG AADPK AAIAV ABYKQ AFYLN AJBFU 9DU AAYXX CITATION AGCQF AGRNS BNPGV CGR CUY CVF ECM EIF NPM SSH 7X8 7QG 7T5 7TK H94 |
| ID | FETCH-LOGICAL-c590t-434cd6f1c378f3f25a11e4af1cd6bb686230d9b4fddf7c357365f5984fa5b5a73 |
| ISICitedReferencesCount | 410 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000344429900008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0889-1591 1090-2139 |
| IngestDate | Sat Sep 27 23:05:19 EDT 2025 Mon Sep 29 05:20:47 EDT 2025 Mon Jul 21 05:54:18 EDT 2025 Tue Nov 18 21:26:45 EST 2025 Sat Nov 29 07:14:47 EST 2025 Fri Feb 23 02:27:19 EST 2024 Sun Feb 23 10:19:16 EST 2025 Tue Oct 14 19:29:44 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Human Perivascular macrophages Anterior cingulate cortex Depression Neuroinflammation Suicide Microglia |
| Language | English |
| License | Copyright © 2014 Elsevier Inc. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c590t-434cd6f1c378f3f25a11e4af1cd6bb686230d9b4fddf7c357365f5984fa5b5a73 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 24858659 |
| PQID | 1629963183 |
| PQPubID | 23479 |
| PageCount | 10 |
| ParticipantIDs | proquest_miscellaneous_1647003030 proquest_miscellaneous_1629963183 pubmed_primary_24858659 crossref_citationtrail_10_1016_j_bbi_2014_05_007 crossref_primary_10_1016_j_bbi_2014_05_007 elsevier_sciencedirect_doi_10_1016_j_bbi_2014_05_007 elsevier_clinicalkeyesjournals_1_s2_0_S0889159114001299 elsevier_clinicalkey_doi_10_1016_j_bbi_2014_05_007 |
| PublicationCentury | 2000 |
| PublicationDate | 2014-11-01 |
| PublicationDateYYYYMMDD | 2014-11-01 |
| PublicationDate_xml | – month: 11 year: 2014 text: 2014-11-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Brain, behavior, and immunity |
| PublicationTitleAlternate | Brain Behav Immun |
| PublicationYear | 2014 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Haroon, Woolwine, Chen, Pace, Parekh, Spivey (b0105) 2014; 39 Steiner, Walter, Gos, Guillemin, Bernstein, Sarnyai (b0195) 2011; 8 Capuron, Miller (b0030) 2004; 56 Imai, Kohsaka (b0115) 2002; 40 Wohleb, Fenn, Pacenta, Powell, Sheridan, Godbout (b0225) 2012; 37 Torres-Platas, Comeau, Rachalski, Bo, Cruceanu, Turecki (b0210) 2014; 11 Pandey, Rizavi, Ren, Fareed, Hoppensteadt, Roberts (b0170) 2012; 46 Dowlati, Herrmann, Swardfager, Liu, Sham, Reim (b0060) 2010; 67 Edgar, Sibille (b0075) 2012; 2 Miller, Maletic, Raison (b0165) 2009; 65 Aguliar-Valles, Kim, Jung, Woodside, Luheshi (b0005) 2013; 19 Bracht, Horn, Strik, Federspiel, Schnell, Hofle (b0025) 2013; 155 Bessette, Nave, Caprihan, Stevens (b0020) 2013 Chen, Dilsaver (b0045) 1996; 39 Soltys, Ziaja, Pawlinski, Setkowicz, Janeczko (b0185) 2001; 63 Ebert, Ebmeier (b0070) 1996; 39 World Health Organization (2012). Media Centre Fact Sheet No. 369 Dean (b0055) 2011; 14 . Lichtblau, Schmidt, Schumann, Kirkby, Himmerich (b0135) 2013; 25 Serrats, Schiltz, Garcia-Bueno, van Rooijen, Reyes, Sawchenko (b0175) 2010; 65 Vogt, Nimchinsky, Vogt, Hof (b0220) 1995; 359 Torres-Platas, Hercher, Davoli, Maussion, Labonte, Turecki (b0215) 2011; 36 Merali, Brennan, Brau, Anisman (b0155) 2003; 165 Bay-Richter, Janelidze, Hallberg, Brundin (b0015) 2011; 222 Hercher, Parent, Flores, Canetti, Turecki, Mechawar (b0110) 2009; 34 Dantzer, O’Connor, Freund, Johnson, Kelley (b0050) 2008; 9 Capuron, Pagnoni, Demetrashvili, Woolwine, Nemeroff, Berns (b0035) 2005; 58 Steiner, Bielau, Brisch, Danos, Ullrich, Mawrin (b0190) 2008; 42 Stence, Waite, Dailey (b0200) 2001; 33 Wohleb, Powell, Godbout, Sheridan (b9010) 2013; 33 Malaguarnera, Di Fazio, Restuccia, Pistone, Ferlito, Rampello (b0145) 1998; 37 Kettenmann, Hanisch, Noda, Verkhratsky (b0125) 2011; 91 McNally, Bhagwagar, Hannestad (b0150) 2008; 13 Karperien, Ahammer, Jelinek (b0120) 2013; 7 Tonelli, Stiller, Rujescu, Giegling, Schneider, Maurer (b0205) 2008; 117 Frasure-Smith, Lesperance (b0085) 2006; 31 Kim, Lesage, Seguin, Chawky, Vanier, Lipp (b0130) 2003; 33 Guillemin, Brew (b0100) 2004; 75 Sofroniew, Vinters (b0180) 2010; 119 Miller, Haroon, Raison, Felger (b0160) 2013; 30 Erhardt, Lim, Linderholm, Janelidze, Lindqvist, Samuelsson (b0080) 2013; 38 Dumais, Lesage, Alda, Rouleau, Dumont, Chawky (b0065) 2005; 162 World Health Organization (2006). World Mental Health Day 2006: ‘Building Awareness – Reducing Risks: Suicide and Mental Illness Chana, Landau, Beasley, Everall, Cotter (b0040) 2003; 53 Eyo, Dailey (b9005) 2012; 60 Gittins, Harrison (b0090) 2004; 1013 Audoy-Remus, Richard, Soulet, Zhou, Kubes, Vallieres (b0010) 2008; 28 Maes, Yirmyia, Noraberg, Brene, Hibbeln, Perini (b0140) 2009; 24 Goshen, Kreisel, Ben-Menachem-Zidon, Licht, Weidenfeld, Ben-Hur (b0095) 2008; 13 Dibaj, Steffens, Nadrigny, Neusch, Kirchhoff, Schomburg (b9000) 2010; 88 Goshen (10.1016/j.bbi.2014.05.007_b0095) 2008; 13 Audoy-Remus (10.1016/j.bbi.2014.05.007_b0010) 2008; 28 10.1016/j.bbi.2014.05.007_b0230 Aguliar-Valles (10.1016/j.bbi.2014.05.007_b0005) 2013; 19 Stence (10.1016/j.bbi.2014.05.007_b0200) 2001; 33 10.1016/j.bbi.2014.05.007_b0235 Guillemin (10.1016/j.bbi.2014.05.007_b0100) 2004; 75 Dibaj (10.1016/j.bbi.2014.05.007_b9000) 2010; 88 Lichtblau (10.1016/j.bbi.2014.05.007_b0135) 2013; 25 Pandey (10.1016/j.bbi.2014.05.007_b0170) 2012; 46 Erhardt (10.1016/j.bbi.2014.05.007_b0080) 2013; 38 Sofroniew (10.1016/j.bbi.2014.05.007_b0180) 2010; 119 Dowlati (10.1016/j.bbi.2014.05.007_b0060) 2010; 67 McNally (10.1016/j.bbi.2014.05.007_b0150) 2008; 13 Capuron (10.1016/j.bbi.2014.05.007_b0030) 2004; 56 Serrats (10.1016/j.bbi.2014.05.007_b0175) 2010; 65 Chana (10.1016/j.bbi.2014.05.007_b0040) 2003; 53 Wohleb (10.1016/j.bbi.2014.05.007_b0225) 2012; 37 Steiner (10.1016/j.bbi.2014.05.007_b0195) 2011; 8 Frasure-Smith (10.1016/j.bbi.2014.05.007_b0085) 2006; 31 Maes (10.1016/j.bbi.2014.05.007_b0140) 2009; 24 Eyo (10.1016/j.bbi.2014.05.007_b9005) 2012; 60 Hercher (10.1016/j.bbi.2014.05.007_b0110) 2009; 34 Miller (10.1016/j.bbi.2014.05.007_b0165) 2009; 65 Soltys (10.1016/j.bbi.2014.05.007_b0185) 2001; 63 Torres-Platas (10.1016/j.bbi.2014.05.007_b0215) 2011; 36 Bay-Richter (10.1016/j.bbi.2014.05.007_b0015) 2011; 222 Steiner (10.1016/j.bbi.2014.05.007_b0190) 2008; 42 Malaguarnera (10.1016/j.bbi.2014.05.007_b0145) 1998; 37 Bracht (10.1016/j.bbi.2014.05.007_b0025) 2013; 155 Karperien (10.1016/j.bbi.2014.05.007_b0120) 2013; 7 Chen (10.1016/j.bbi.2014.05.007_b0045) 1996; 39 Tonelli (10.1016/j.bbi.2014.05.007_b0205) 2008; 117 Gittins (10.1016/j.bbi.2014.05.007_b0090) 2004; 1013 Imai (10.1016/j.bbi.2014.05.007_b0115) 2002; 40 Vogt (10.1016/j.bbi.2014.05.007_b0220) 1995; 359 Haroon (10.1016/j.bbi.2014.05.007_b0105) 2014; 39 Dean (10.1016/j.bbi.2014.05.007_b0055) 2011; 14 Kettenmann (10.1016/j.bbi.2014.05.007_b0125) 2011; 91 Miller (10.1016/j.bbi.2014.05.007_b0160) 2013; 30 Dantzer (10.1016/j.bbi.2014.05.007_b0050) 2008; 9 Torres-Platas (10.1016/j.bbi.2014.05.007_b0210) 2014; 11 Ebert (10.1016/j.bbi.2014.05.007_b0070) 1996; 39 Bessette (10.1016/j.bbi.2014.05.007_b0020) 2013 Wohleb (10.1016/j.bbi.2014.05.007_b9010) 2013; 33 Capuron (10.1016/j.bbi.2014.05.007_b0035) 2005; 58 Merali (10.1016/j.bbi.2014.05.007_b0155) 2003; 165 Kim (10.1016/j.bbi.2014.05.007_b0130) 2003; 33 Edgar (10.1016/j.bbi.2014.05.007_b0075) 2012; 2 Dumais (10.1016/j.bbi.2014.05.007_b0065) 2005; 162 25128842 - Brain Behav Immun. 2014 Nov;42:48-9 |
| References_xml | – volume: 31 start-page: 64 year: 2006 end-page: 68 ident: b0085 article-title: Depression and coronary artery disease publication-title: Herz – volume: 9 start-page: 46 year: 2008 end-page: 56 ident: b0050 article-title: From inflammation to sickness and depression: when the immune system subjugates the brain publication-title: Nat. Rev. Neurosci. – year: 2013 ident: b0020 article-title: White matter abnormalities in adolescents with major depressive disorder publication-title: Brain Imaging Behav. – volume: 56 start-page: 819 year: 2004 end-page: 824 ident: b0030 article-title: Cytokines and psychopathology: lessons from interferon-alpha publication-title: Biol. Psychiatry – volume: 13 start-page: 717 year: 2008 end-page: 728 ident: b0095 article-title: Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression publication-title: Mol. Psychiatry – volume: 359 start-page: 490 year: 1995 end-page: 506 ident: b0220 article-title: Human cingulate cortex: surface features, flat maps, and cytoarchitecture publication-title: J. Comp. Neurol. – volume: 65 start-page: 732 year: 2009 end-page: 741 ident: b0165 article-title: Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression publication-title: Biol. Psychiatry – volume: 67 start-page: 446 year: 2010 end-page: 457 ident: b0060 article-title: A meta-analysis of cytokines in major depression publication-title: Biol. Psychiatry – volume: 37 start-page: 93 year: 1998 end-page: 97 ident: b0145 article-title: Interferon alpha-induced depression in chronic hepatitis C patients: comparison between different types of interferon alpha publication-title: Neuropsychobiology – volume: 60 start-page: 1747 year: 2012 end-page: 1760 ident: b9005 article-title: Effects of oxygen-glucose deprivation on microglial mobility and viability in developing mouse hippocampal tissues publication-title: Glia – volume: 39 start-page: 1777 year: 2014 end-page: 1785 ident: b0105 article-title: IFN-alpha-induced cortical and subcortical glutamate changes assessed by magnetic resonance spectroscopy publication-title: Neuropsychopharmacology – volume: 53 start-page: 1086 year: 2003 end-page: 1098 ident: b0040 article-title: Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density publication-title: Biol. Psychiatry – volume: 11 start-page: 12 year: 2014 ident: b0210 article-title: Morphometric characterization of microglial phenotypes in human cerebral cortex publication-title: J. Neuroinflammation – volume: 2 start-page: e109 year: 2012 ident: b0075 article-title: A putative functional role for oligodendrocytes in mood regulation publication-title: Transl. Psychiatry – volume: 75 start-page: 388 year: 2004 end-page: 397 ident: b0100 article-title: Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification publication-title: J. Leukoc. Biol. – volume: 155 start-page: 186 year: 2013 end-page: 193 ident: b0025 article-title: White matter microstructure alterations of the medial forebrain bundle in melancholic depression publication-title: J. Affect. Disord. – volume: 24 start-page: 27 year: 2009 end-page: 53 ident: b0140 article-title: The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression publication-title: Metab. Brain Dis. – volume: 8 start-page: 94 year: 2011 ident: b0195 article-title: Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? publication-title: J. Neuroinflammation – volume: 42 start-page: 151 year: 2008 end-page: 157 ident: b0190 article-title: Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide publication-title: J. Psychiatric Res. – volume: 39 start-page: 1044 year: 1996 end-page: 1050 ident: b0070 article-title: The role of the cingulate gyrus in depression: from functional anatomy to neurochemistry publication-title: Biol. Psychiatry – volume: 28 start-page: 10187 year: 2008 end-page: 10199 ident: b0010 article-title: Rod-Shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of proinflammatory cytokines and angiopoietin-2 publication-title: J. Neurosci. – volume: 7 start-page: 3 year: 2013 ident: b0120 article-title: Quantitating the subtleties of microglial morphology with fractal analysis publication-title: Front. Cell. Neurosci. – volume: 34 start-page: 281 year: 2009 end-page: 288 ident: b0110 article-title: Alcohol dependence-related increase of glial cell density in the anterior cingulate cortex of suicide completers publication-title: J. Psychiatry Neurosci. – volume: 40 start-page: 164 year: 2002 end-page: 174 ident: b0115 article-title: Intracellular signaling in M-CSF-induced microglia activation: role of Iba1 publication-title: Glia – volume: 13 start-page: 501 year: 2008 end-page: 510 ident: b0150 article-title: Inflammation, glutamate, and glia in depression: a literature review publication-title: CNS Spectr. – volume: 222 start-page: 193 year: 2011 end-page: 199 ident: b0015 article-title: Changes in behaviour and cytokine expression upon a peripheral immune challenge publication-title: Behav. Brain Res. – volume: 14 start-page: 997 year: 2011 end-page: 1012 ident: b0055 article-title: Understanding the role of inflammatory-related pathways in the pathophysiology and treatment of psychiatric disorders: evidence from human peripheral studies and CNS studies publication-title: Int. J. Neuropsychopharmacol. – volume: 33 start-page: 1299 year: 2003 end-page: 1309 ident: b0130 article-title: Patterns of co-morbidity in male suicide completers publication-title: Psychol. Med. – volume: 39 start-page: 896 year: 1996 end-page: 899 ident: b0045 article-title: Lifetime rates of suicide attempts among subjects with bipolar and unipolar disorders relative to subjects with other Axis I disorders publication-title: Biol. Psychiatry – volume: 65 start-page: 94 year: 2010 end-page: 106 ident: b0175 article-title: Dual roles for perivascular macrophages in immune-to-brain signaling publication-title: Neuron – volume: 36 start-page: 2650 year: 2011 end-page: 2658 ident: b0215 article-title: Astrocytic hypertrophy in anterior cingulate white matter of depressed suicides publication-title: Neuropsychopharmacology – volume: 88 start-page: 2431 year: 2010 end-page: 2440 ident: b9000 article-title: Longlasting post-mortem activity of spinal microglia in situ in mice publication-title: J. Neurosci. Res. – volume: 33 start-page: 256 year: 2001 end-page: 266 ident: b0200 article-title: Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices publication-title: Glia – volume: 58 start-page: 190 year: 2005 end-page: 196 ident: b0035 article-title: Anterior cingulate activation and error processing during interferon-alpha treatment publication-title: Biol. Psychiatry – reference: World Health Organization (2012). Media Centre Fact Sheet No. 369 – volume: 63 start-page: 90 year: 2001 end-page: 97 ident: b0185 article-title: Morphology of reactive microglia in the injured cerebral cortex. Fractal analysis and complementary quantitative methods publication-title: J. Neurosci. Res. – volume: 119 start-page: 7 year: 2010 end-page: 35 ident: b0180 article-title: Astrocytes: biology and pathology publication-title: Acta Neuropathol. – volume: 91 start-page: 461 year: 2011 end-page: 553 ident: b0125 article-title: Physiology of microglia publication-title: Physiol. Rev. – volume: 37 start-page: 1491 year: 2012 end-page: 1505 ident: b0225 article-title: Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice publication-title: Psychoneuroendocrinology – volume: 1013 start-page: 212 year: 2004 end-page: 222 ident: b0090 article-title: A quantitative morphometric study of the human anterior cingulate cortex publication-title: Brain Res. – reference: World Health Organization (2006). World Mental Health Day 2006: ‘Building Awareness – Reducing Risks: Suicide and Mental Illness – reference: . – volume: 38 start-page: 743 year: 2013 end-page: 752 ident: b0080 article-title: Connecting inflammation with glutamate agonism in suicidality publication-title: Neuropsychopharmacology – volume: 46 start-page: 57 year: 2012 end-page: 63 ident: b0170 article-title: Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims publication-title: J. Psychiatric Res. – volume: 165 start-page: 413 year: 2003 end-page: 418 ident: b0155 article-title: Dissociating anorexia and anhedonia elicited by interleukin-1beta: antidepressant and gender effects on responding for “free chow” and “earned” sucrose intake publication-title: Psychopharmacology – volume: 25 start-page: 592 year: 2013 end-page: 603 ident: b0135 article-title: Cytokines as biomarkers in depressive disorder: current standing and prospects publication-title: Int. Rev. Psychiatry – volume: 117 start-page: 198 year: 2008 end-page: 206 ident: b0205 article-title: Elevated cytokine expression in the orbitofrontal cortex of victims of suicide publication-title: Acta Psychiatr. Scand. – volume: 30 start-page: 297 year: 2013 end-page: 306 ident: b0160 article-title: Cytokine targets in the brain: impact on neurotransmitters and neurocircuits publication-title: Depress. Anxiety – volume: 19 start-page: 633 year: 2013 ident: b0005 article-title: Role of brain transmigrating neutrophils in depression-like behavior during systemic infection publication-title: Mol. Psychiatry – volume: 33 start-page: 13820 year: 2013 end-page: 13833 ident: b9010 article-title: Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior publication-title: J. Neurosci. – volume: 162 start-page: 2116 year: 2005 end-page: 2124 ident: b0065 article-title: Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men publication-title: Am. J. Psychiatry – volume: 33 start-page: 256 issue: 3 year: 2001 ident: 10.1016/j.bbi.2014.05.007_b0200 article-title: Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices publication-title: Glia doi: 10.1002/1098-1136(200103)33:3<256::AID-GLIA1024>3.0.CO;2-J – volume: 25 start-page: 592 issue: 5 year: 2013 ident: 10.1016/j.bbi.2014.05.007_b0135 article-title: Cytokines as biomarkers in depressive disorder: current standing and prospects publication-title: Int. Rev. Psychiatry doi: 10.3109/09540261.2013.813442 – volume: 155 start-page: 186 year: 2013 ident: 10.1016/j.bbi.2014.05.007_b0025 article-title: White matter microstructure alterations of the medial forebrain bundle in melancholic depression publication-title: J. Affect. Disord. doi: 10.1016/j.jad.2013.10.048 – volume: 119 start-page: 7 issue: 1 year: 2010 ident: 10.1016/j.bbi.2014.05.007_b0180 article-title: Astrocytes: biology and pathology publication-title: Acta Neuropathol. doi: 10.1007/s00401-009-0619-8 – volume: 39 start-page: 1044 issue: 12 year: 1996 ident: 10.1016/j.bbi.2014.05.007_b0070 article-title: The role of the cingulate gyrus in depression: from functional anatomy to neurochemistry publication-title: Biol. Psychiatry doi: 10.1016/0006-3223(95)00320-7 – volume: 13 start-page: 501 issue: 6 year: 2008 ident: 10.1016/j.bbi.2014.05.007_b0150 article-title: Inflammation, glutamate, and glia in depression: a literature review publication-title: CNS Spectr. doi: 10.1017/S1092852900016734 – volume: 36 start-page: 2650 issue: 13 year: 2011 ident: 10.1016/j.bbi.2014.05.007_b0215 article-title: Astrocytic hypertrophy in anterior cingulate white matter of depressed suicides publication-title: Neuropsychopharmacology doi: 10.1038/npp.2011.154 – volume: 39 start-page: 896 issue: 10 year: 1996 ident: 10.1016/j.bbi.2014.05.007_b0045 article-title: Lifetime rates of suicide attempts among subjects with bipolar and unipolar disorders relative to subjects with other Axis I disorders publication-title: Biol. Psychiatry doi: 10.1016/0006-3223(95)00295-2 – volume: 60 start-page: 1747 year: 2012 ident: 10.1016/j.bbi.2014.05.007_b9005 article-title: Effects of oxygen-glucose deprivation on microglial mobility and viability in developing mouse hippocampal tissues publication-title: Glia doi: 10.1002/glia.22394 – volume: 359 start-page: 490 issue: 3 year: 1995 ident: 10.1016/j.bbi.2014.05.007_b0220 article-title: Human cingulate cortex: surface features, flat maps, and cytoarchitecture publication-title: J. Comp. Neurol. doi: 10.1002/cne.903590310 – volume: 91 start-page: 461 issue: 2 year: 2011 ident: 10.1016/j.bbi.2014.05.007_b0125 article-title: Physiology of microglia publication-title: Physiol. Rev. doi: 10.1152/physrev.00011.2010 – volume: 33 start-page: 1299 issue: 7 year: 2003 ident: 10.1016/j.bbi.2014.05.007_b0130 article-title: Patterns of co-morbidity in male suicide completers publication-title: Psychol. Med. doi: 10.1017/S0033291703008146 – volume: 28 start-page: 10187 issue: 41 year: 2008 ident: 10.1016/j.bbi.2014.05.007_b0010 article-title: Rod-Shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of proinflammatory cytokines and angiopoietin-2 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3510-08.2008 – ident: 10.1016/j.bbi.2014.05.007_b0235 – volume: 24 start-page: 27 issue: 1 year: 2009 ident: 10.1016/j.bbi.2014.05.007_b0140 article-title: The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression publication-title: Metab. Brain Dis. doi: 10.1007/s11011-008-9118-1 – volume: 162 start-page: 2116 issue: 11 year: 2005 ident: 10.1016/j.bbi.2014.05.007_b0065 article-title: Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.162.11.2116 – volume: 165 start-page: 413 issue: 4 year: 2003 ident: 10.1016/j.bbi.2014.05.007_b0155 article-title: Dissociating anorexia and anhedonia elicited by interleukin-1beta: antidepressant and gender effects on responding for “free chow” and “earned” sucrose intake publication-title: Psychopharmacology doi: 10.1007/s00213-002-1273-1 – year: 2013 ident: 10.1016/j.bbi.2014.05.007_b0020 article-title: White matter abnormalities in adolescents with major depressive disorder publication-title: Brain Imaging Behav. – volume: 67 start-page: 446 issue: 5 year: 2010 ident: 10.1016/j.bbi.2014.05.007_b0060 article-title: A meta-analysis of cytokines in major depression publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2009.09.033 – volume: 31 start-page: 64 issue: Suppl. 3 year: 2006 ident: 10.1016/j.bbi.2014.05.007_b0085 article-title: Depression and coronary artery disease publication-title: Herz – volume: 1013 start-page: 212 issue: 2 year: 2004 ident: 10.1016/j.bbi.2014.05.007_b0090 article-title: A quantitative morphometric study of the human anterior cingulate cortex publication-title: Brain Res. doi: 10.1016/j.brainres.2004.03.064 – volume: 63 start-page: 90 issue: 1 year: 2001 ident: 10.1016/j.bbi.2014.05.007_b0185 article-title: Morphology of reactive microglia in the injured cerebral cortex. Fractal analysis and complementary quantitative methods publication-title: J. Neurosci. Res. doi: 10.1002/1097-4547(20010101)63:1<90::AID-JNR11>3.0.CO;2-9 – volume: 37 start-page: 1491 issue: 9 year: 2012 ident: 10.1016/j.bbi.2014.05.007_b0225 article-title: Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2012.02.003 – volume: 33 start-page: 13820 issue: 34 year: 2013 ident: 10.1016/j.bbi.2014.05.007_b9010 article-title: Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1671-13.2013 – volume: 53 start-page: 1086 issue: 12 year: 2003 ident: 10.1016/j.bbi.2014.05.007_b0040 article-title: Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density publication-title: Biol. Psychiatry doi: 10.1016/S0006-3223(03)00114-8 – volume: 37 start-page: 93 issue: 2 year: 1998 ident: 10.1016/j.bbi.2014.05.007_b0145 article-title: Interferon alpha-induced depression in chronic hepatitis C patients: comparison between different types of interferon alpha publication-title: Neuropsychobiology doi: 10.1159/000026485 – volume: 65 start-page: 732 issue: 9 year: 2009 ident: 10.1016/j.bbi.2014.05.007_b0165 article-title: Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2008.11.029 – volume: 117 start-page: 198 issue: 3 year: 2008 ident: 10.1016/j.bbi.2014.05.007_b0205 article-title: Elevated cytokine expression in the orbitofrontal cortex of victims of suicide publication-title: Acta Psychiatr. Scand. doi: 10.1111/j.1600-0447.2007.01128.x – volume: 222 start-page: 193 issue: 1 year: 2011 ident: 10.1016/j.bbi.2014.05.007_b0015 article-title: Changes in behaviour and cytokine expression upon a peripheral immune challenge publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2011.03.060 – volume: 14 start-page: 997 issue: 7 year: 2011 ident: 10.1016/j.bbi.2014.05.007_b0055 article-title: Understanding the role of inflammatory-related pathways in the pathophysiology and treatment of psychiatric disorders: evidence from human peripheral studies and CNS studies publication-title: Int. J. Neuropsychopharmacol. doi: 10.1017/S1461145710001410 – volume: 46 start-page: 57 issue: 1 year: 2012 ident: 10.1016/j.bbi.2014.05.007_b0170 article-title: Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims publication-title: J. Psychiatric Res. doi: 10.1016/j.jpsychires.2011.08.006 – ident: 10.1016/j.bbi.2014.05.007_b0230 – volume: 42 start-page: 151 issue: 2 year: 2008 ident: 10.1016/j.bbi.2014.05.007_b0190 article-title: Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide publication-title: J. Psychiatric Res. doi: 10.1016/j.jpsychires.2006.10.013 – volume: 9 start-page: 46 issue: 1 year: 2008 ident: 10.1016/j.bbi.2014.05.007_b0050 article-title: From inflammation to sickness and depression: when the immune system subjugates the brain publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn2297 – volume: 34 start-page: 281 issue: 4 year: 2009 ident: 10.1016/j.bbi.2014.05.007_b0110 article-title: Alcohol dependence-related increase of glial cell density in the anterior cingulate cortex of suicide completers publication-title: J. Psychiatry Neurosci. doi: 10.1139/jpn.0937 – volume: 39 start-page: 1777 issue: 7 year: 2014 ident: 10.1016/j.bbi.2014.05.007_b0105 article-title: IFN-alpha-induced cortical and subcortical glutamate changes assessed by magnetic resonance spectroscopy publication-title: Neuropsychopharmacology doi: 10.1038/npp.2014.25 – volume: 40 start-page: 164 issue: 2 year: 2002 ident: 10.1016/j.bbi.2014.05.007_b0115 article-title: Intracellular signaling in M-CSF-induced microglia activation: role of Iba1 publication-title: Glia doi: 10.1002/glia.10149 – volume: 88 start-page: 2431 year: 2010 ident: 10.1016/j.bbi.2014.05.007_b9000 article-title: Longlasting post-mortem activity of spinal microglia in situ in mice publication-title: J. Neurosci. Res. doi: 10.1002/jnr.22402 – volume: 13 start-page: 717 issue: 7 year: 2008 ident: 10.1016/j.bbi.2014.05.007_b0095 article-title: Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression publication-title: Mol. Psychiatry doi: 10.1038/sj.mp.4002055 – volume: 2 start-page: e109 year: 2012 ident: 10.1016/j.bbi.2014.05.007_b0075 article-title: A putative functional role for oligodendrocytes in mood regulation publication-title: Transl. Psychiatry doi: 10.1038/tp.2012.34 – volume: 75 start-page: 388 issue: 3 year: 2004 ident: 10.1016/j.bbi.2014.05.007_b0100 article-title: Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification publication-title: J. Leukoc. Biol. doi: 10.1189/jlb.0303114 – volume: 30 start-page: 297 issue: 4 year: 2013 ident: 10.1016/j.bbi.2014.05.007_b0160 article-title: Cytokine targets in the brain: impact on neurotransmitters and neurocircuits publication-title: Depress. Anxiety doi: 10.1002/da.22084 – volume: 58 start-page: 190 issue: 3 year: 2005 ident: 10.1016/j.bbi.2014.05.007_b0035 article-title: Anterior cingulate activation and error processing during interferon-alpha treatment publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2005.03.033 – volume: 19 start-page: 633 issue: 5 year: 2013 ident: 10.1016/j.bbi.2014.05.007_b0005 article-title: Role of brain transmigrating neutrophils in depression-like behavior during systemic infection publication-title: Mol. Psychiatry doi: 10.1038/mp.2013.154 – volume: 7 start-page: 3 year: 2013 ident: 10.1016/j.bbi.2014.05.007_b0120 article-title: Quantitating the subtleties of microglial morphology with fractal analysis publication-title: Front. Cell. Neurosci. doi: 10.3389/fncel.2013.00003 – volume: 8 start-page: 94 year: 2011 ident: 10.1016/j.bbi.2014.05.007_b0195 article-title: Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? publication-title: J. Neuroinflammation doi: 10.1186/1742-2094-8-94 – volume: 38 start-page: 743 issue: 5 year: 2013 ident: 10.1016/j.bbi.2014.05.007_b0080 article-title: Connecting inflammation with glutamate agonism in suicidality publication-title: Neuropsychopharmacology doi: 10.1038/npp.2012.248 – volume: 56 start-page: 819 issue: 11 year: 2004 ident: 10.1016/j.bbi.2014.05.007_b0030 article-title: Cytokines and psychopathology: lessons from interferon-alpha publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2004.02.009 – volume: 11 start-page: 12 year: 2014 ident: 10.1016/j.bbi.2014.05.007_b0210 article-title: Morphometric characterization of microglial phenotypes in human cerebral cortex publication-title: J. Neuroinflammation doi: 10.1186/1742-2094-11-12 – volume: 65 start-page: 94 issue: 1 year: 2010 ident: 10.1016/j.bbi.2014.05.007_b0175 article-title: Dual roles for perivascular macrophages in immune-to-brain signaling publication-title: Neuron doi: 10.1016/j.neuron.2009.11.032 – reference: 25128842 - Brain Behav Immun. 2014 Nov;42:48-9 |
| SSID | ssj0005318 |
| Score | 2.5956469 |
| Snippet | Despite increasing evidence supporting the neuroinflammatory theory of depression, little is known about cerebral macrophages in individuals suffering from... Abstract Despite increasing evidence supporting the neuroinflammatory theory of depression, little is known about cerebral macrophages in individuals suffering... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 50 |
| SubjectTerms | Adult Allergy and Immunology Anterior cingulate cortex Depression Depressive Disorder - immunology Depressive Disorder - pathology Depressive Disorder - psychology Female Gyrus Cinguli - immunology Gyrus Cinguli - pathology Human Humans Macrophage Activation - immunology Macrophages - immunology Macrophages - pathology Male Microglia Microglia - immunology Microglia - pathology Middle Aged Neuroinflammation Perivascular macrophages Psychiatry Suicide Suicide - psychology White Matter - immunology White Matter - pathology |
| Title | Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0889159114001299 https://www.clinicalkey.es/playcontent/1-s2.0-S0889159114001299 https://dx.doi.org/10.1016/j.bbi.2014.05.007 https://www.ncbi.nlm.nih.gov/pubmed/24858659 https://www.proquest.com/docview/1629963183 https://www.proquest.com/docview/1647003030 |
| Volume | 42 |
| WOSCitedRecordID | wos000344429900008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1090-2139 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005318 issn: 0889-1591 databaseCode: AIEXJ dateStart: 19950301 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lj9MwELa6uwhxQbDLozxWRkIcQEFJ7MTJsVotBSRWK1Gk3izntXTVplXTluUf8Hv4hcz4kXaBFjhwiaokY6eZL-Ox_c0MIc_9uBIFZ4WnFPc9HsGcNcvS3IsVblqpipWs0sUmxNlZMhym553OdxcLsxqLuk6urtLZf1U1nANlY-jsP6i7bRROwG9QOhxB7XD8K8W7OqGaQDiq0StswKucIPPuYowL5DNdysvEJk4U1vD6jMwdsH3z5ciwzi37sZjOG51MADM6Q3M5iGG9r_LVF9x-AGkMBkKH0zJqoaNmOcrhCZpr28VzZXIVuKwAjjQ60uEpi3Zdf6CLhXjn0IeJNNOsIbWuAHaCWFT1Ui_wWgO1JhvZUJM-UgH7yg7Kmj0Cf84U6O5jxNhqurnaEXAb9qcHK2Oh_dT3wsBkQHIm3CTosjbYJLL9ZWgwqxSXr7NshIw-rhO2moq7G6iYTTQsMNFbEttc5dfzcbtLe-QgFFEKlvSg9-50-H5NLAIz6fbPNZPwpx4x_7RtY5sztG2yo52ewR1y285WaM-g7C7plPUhOerVajGdfKUvqOYP642ZQ3Lzg6VpHJFvDoMUMEhbDNI1BqnFIAUQ0DUG6QYGQY4CBqnBIHUYpC0GqcYgNRik04q2GKQOg_fIpzeng5O3ni354eVR6i88znhexFWQM5FUrAojFQQlV3CiiLMMo5mYX6QZr4qiEjmLBIujKkoTXqkoi5Rg98l-Pa3Lh4SqAO4J_FKwKkYvNWVpmcYwPxBlzLMk7BLfvXuZ23z4WJZlLB3x8VKC5iRqTvqRBM11yctWZGaSwey6OXQKlS7KGcZlCXjcJSR-J1Q21sA0MpBNKH35EemJMBUJAq7XktMu4a2kdZ6NU_ynDp85rEkYWHC3UNXldAkdxdBqjEP-rnu4QDeB-V3ywAC1fTEO44-2XnlMbq0_8SdkfzFflk_JjXy1GDXzY7Inhsmx_bh-AEa_BXc |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evidence+for+increased+microglial+priming+and+macrophage+recruitment+in+the+dorsal+anterior+cingulate+white+matter+of+depressed+suicides&rft.jtitle=Brain%2C+behavior%2C+and+immunity&rft.au=Torres-Platas%2C+Susana+G&rft.au=Cruceanu%2C+Cristiana&rft.au=Chen%2C+Gary+Gang&rft.au=Turecki%2C+Gustavo&rft.date=2014-11-01&rft.eissn=1090-2139&rft.volume=42&rft.spage=50&rft_id=info:doi/10.1016%2Fj.bbi.2014.05.007&rft_id=info%3Apmid%2F24858659&rft.externalDocID=24858659 |
| thumbnail_m | http://cvtisr.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F08891591%2FS0889159114X00085%2Fcov150h.gif |