Novel theranostic nanoplatform for complete mice tumor elimination via MR imaging-guided acid-enhanced photothermo-/chemo-therapy

Non-invasive imaging-guided tumor therapy requires new-generation bio-nanomaterials to sensitively respond to the unique tumor microenvironment for precise diagnosis and efficient treatment. Here, we report such a theranostic nanoplatform by engineering defect-rich multifunctional Cu-doped layered d...

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Veröffentlicht in:Biomaterials Jg. 177; S. 40 - 51
Hauptverfasser: Li, Bei, Tang, Jie, Chen, Weiyu, Hao, Guanyu, Kurniawan, Nyoman, Gu, Zi, Xu, Zhi Ping
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier Ltd 01.09.2018
Schlagworte:
Acid-enhanced photothermal therapy
Animals
Antimetabolites, Antineoplastic - therapeutic use
cations
copper
Copper - therapeutic use
Cu-layered double hydroxides
drug therapy
Female
Fluorouracil - therapeutic use
geometry
Hydroxides - therapeutic use
Hyperthermia, Induced - methods
magnetic resonance imaging
Magnetic Resonance Imaging - methods
Mice
Mice, Inbred BALB C
Mice, Nude
microstructure
nanoparticles
Nanoparticles - therapeutic use
Neoplasms - diagnostic imaging
Neoplasms - therapy
pH-sensitive theranostic agents
Phototherapy - methods
T1–weighted MRI contrast agents
Theranostic Nanomedicine - methods
tissues
Tumor microenvironment
X-ray photoelectron spectroscopy
T1–weighted MRI contrast agents
Acid-enhanced photothermal therapy
Cu-layered double hydroxides
Tumor microenvironment
pH-sensitive theranostic agents
T–weighted MRI contrast agents
ISSN:0142-9612, 1878-5905, 1878-5905
Online-Zugang:Volltext
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Zusammenfassung:Non-invasive imaging-guided tumor therapy requires new-generation bio-nanomaterials to sensitively respond to the unique tumor microenvironment for precise diagnosis and efficient treatment. Here, we report such a theranostic nanoplatform by engineering defect-rich multifunctional Cu-doped layered double hydroxide (Cu-LDH) nanoparticles, which integrates pH-sensitive T1-magnetic resonance imaging (MRI), acid-enhanced photothermal therapy and heat-facilitated chemotherapy. As characterized with EXAFS and XPS, smaller Cu-LDH nanoparticles possess a considerable amount of defects around Cu cations, an advantageous microstructure that enables a high photothermal conversion of 808 nm NIR laser (53.1%). The exposure of CuOH octahedra on the LDH surface makes the photothermal conversion significantly acid-enhanced (53.1% at pH 7.0 vs. 81.9% at pH 5.0). This Cu peculiar microstructure also makes T1-MRI very pH-sensitive, a desirable guide for subsequent tumor photothermal therapy. Combined photothermal therapy and chemotherapy lead to nearly complete elimination of tumor tissues in vivo with a low injection dose of agents. Therefore, this novel defect-rich Cu-LDH nanoplatform is one of promising tumor-specific nanotheranostic agents for non-invasive imaging-guided combinational therapy. [Display omitted]
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0142-9612
1878-5905
1878-5905
DOI:10.1016/j.biomaterials.2018.05.055