Novel theranostic nanoplatform for complete mice tumor elimination via MR imaging-guided acid-enhanced photothermo-/chemo-therapy

Non-invasive imaging-guided tumor therapy requires new-generation bio-nanomaterials to sensitively respond to the unique tumor microenvironment for precise diagnosis and efficient treatment. Here, we report such a theranostic nanoplatform by engineering defect-rich multifunctional Cu-doped layered d...

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Veröffentlicht in:	Biomaterials Jg. 177; S. 40 - 51
Hauptverfasser:	Li, Bei, Tang, Jie, Chen, Weiyu, Hao, Guanyu, Kurniawan, Nyoman, Gu, Zi, Xu, Zhi Ping
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier Ltd 01.09.2018
Schlagworte:	Acid-enhanced photothermal therapy Animals Antimetabolites, Antineoplastic - therapeutic use cations copper Copper - therapeutic use Cu-layered double hydroxides drug therapy Female Fluorouracil - therapeutic use geometry Hydroxides - therapeutic use Hyperthermia, Induced - methods magnetic resonance imaging Magnetic Resonance Imaging - methods Mice Mice, Inbred BALB C Mice, Nude microstructure nanoparticles Nanoparticles - therapeutic use Neoplasms - diagnostic imaging Neoplasms - therapy pH-sensitive theranostic agents Phototherapy - methods T1–weighted MRI contrast agents Theranostic Nanomedicine - methods tissues Tumor microenvironment X-ray photoelectron spectroscopy T1–weighted MRI contrast agents Acid-enhanced photothermal therapy Cu-layered double hydroxides Tumor microenvironment pH-sensitive theranostic agents T–weighted MRI contrast agents
ISSN:	0142-9612, 1878-5905, 1878-5905
Online-Zugang:	Volltext
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