Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints

Background The HIV-1 genome is subject to pressures that target the virus resulting in escape and adaptation. On the other hand, there is a requirement for sequence conservation because of functional and structural constraints. Mapping the sites of selective pressure and conservation on the viral ge...

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Bibliographic Details
Published in:	Retrovirology Vol. 8; no. 1; p. 87
Main Authors:	Snoeck, Joke, Fellay, Jacques, Bartha, István, Douek, Daniel C, Telenti, Amalio
Format:	Journal Article
Language:	English
Published:	London BioMed Central 01.11.2011 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Amino acids Antibodies Biomedical and Life Sciences Biomedicine Cancer Research Chromosome Mapping Confidence intervals evolution Evolution, Molecular Genetic aspects Genetic diversity Genome, Viral Genomes HIV HIV (Viruses) HIV Infections - virology HIV-1 - genetics Humans Immune system Infectious Diseases Life sciences Molecular Sequence Data Multivariate analysis Physiological aspects positive selection Protein Structure Reading RNA structure RNA, Viral - genetics Selection, Genetic Vaccine Viral Proteins - genetics Virology Belgium United States Switzerland positive selection evolution HIV RNA structure
ISSN:	1742-4690, 1742-4690
Online Access:	Get full text
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