Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus

The influenza A virus M2 proton channel (A/M2) is the target of the antiviral drugs amantadine and rimantadine, whose use has been discontinued due to widespread drug resistance. Among the handful of drug-resistant mutants, S31N is found in more than 95% of the currently circulating viruses and show...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 110; H. 4; S. 1315
Hauptverfasser:	Wang, Jun, Wu, Yibing, Ma, Chunlong, Fiorin, Giacomo, Wang, Jizhou, Pinto, Lawrence H, Lamb, Robert A, Klein, Michael L, Degrado, William F
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 22.01.2013
Schlagworte:	Amantadine - analogs & derivatives Amantadine - chemical synthesis Amantadine - chemistry Amantadine - pharmacology Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Binding Sites Drug Design Drug Resistance, Viral - genetics Genes, Fungal Humans Influenza A virus - chemistry Influenza A virus - drug effects Influenza A virus - genetics Models, Molecular Mutation Nuclear Magnetic Resonance, Biomolecular Recombinant Proteins - antagonists & inhibitors Recombinant Proteins - chemistry Recombinant Proteins - genetics Structure-Activity Relationship Viral Matrix Proteins - antagonists & inhibitors Viral Matrix Proteins - chemistry Viral Matrix Proteins - genetics
ISSN:	1091-6490, 1091-6490
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