Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock

The circadian clock provides organisms with the ability to adapt to daily and seasonal cycles. Eukaryotic clocks mostly rely on lineage-specific transcriptional-translational feedback loops (TTFLs). Posttranslational modifications are also crucial for clock functions in fungi and animals, but the po...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS Jg. 116; H. 23; S. 11528
Hauptverfasser: Uehara, Takahiro N, Mizutani, Yoshiyuki, Kuwata, Keiko, Hirota, Tsuyoshi, Sato, Ayato, Mizoi, Junya, Takao, Saori, Matsuo, Hiromi, Suzuki, Takamasa, Ito, Shogo, Saito, Ami N, Nishiwaki-Ohkawa, Taeko, Yamaguchi-Shinozaki, Kazuko, Yoshimura, Takashi, Kay, Steve A, Itami, Kenichiro, Kinoshita, Toshinori, Yamaguchi, Junichiro, Nakamichi, Norihito
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Sprache:Englisch
Veröffentlicht: United States 04.06.2019
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ISSN:1091-6490, 1091-6490
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Abstract The circadian clock provides organisms with the ability to adapt to daily and seasonal cycles. Eukaryotic clocks mostly rely on lineage-specific transcriptional-translational feedback loops (TTFLs). Posttranslational modifications are also crucial for clock functions in fungi and animals, but the posttranslational modifications that affect the plant clock are less understood. Here, using chemical biology strategies, we show that the CASEIN KINASE 1 LIKE (CKL) family is involved in posttranslational modification in the plant clock. Chemical screening demonstrated that an animal CDC7/CDK9 inhibitor, PHA767491, lengthens the circadian period. Affinity proteomics using a chemical probe revealed that PHA767491 binds to and inhibits multiple CKL proteins, rather than CDC7/CDK9 homologs. Simultaneous knockdown of CKL-encoding genes lengthened the circadian period. CKL4 phosphorylated transcriptional repressors PSEUDO-RESPONSE REGULATOR 5 (PRR5) and TIMING OF CAB EXPRESSION 1 (TOC1) in the TTFL. PHA767491 treatment resulted in accumulation of PRR5 and TOC1, accompanied by decreasing expression of PRR5- and TOC1-target genes. A double mutant was hyposensitive to PHA767491-induced period lengthening. Together, our results reveal posttranslational modification of transcriptional repressors in plant clock TTFL by CK1 family proteins, which also modulate nonplant circadian clocks.
AbstractList The circadian clock provides organisms with the ability to adapt to daily and seasonal cycles. Eukaryotic clocks mostly rely on lineage-specific transcriptional-translational feedback loops (TTFLs). Posttranslational modifications are also crucial for clock functions in fungi and animals, but the posttranslational modifications that affect the plant clock are less understood. Here, using chemical biology strategies, we show that the CASEIN KINASE 1 LIKE (CKL) family is involved in posttranslational modification in the plant clock. Chemical screening demonstrated that an animal CDC7/CDK9 inhibitor, PHA767491, lengthens the circadian period. Affinity proteomics using a chemical probe revealed that PHA767491 binds to and inhibits multiple CKL proteins, rather than CDC7/CDK9 homologs. Simultaneous knockdown of CKL-encoding genes lengthened the circadian period. CKL4 phosphorylated transcriptional repressors PSEUDO-RESPONSE REGULATOR 5 (PRR5) and TIMING OF CAB EXPRESSION 1 (TOC1) in the TTFL. PHA767491 treatment resulted in accumulation of PRR5 and TOC1, accompanied by decreasing expression of PRR5- and TOC1-target genes. A double mutant was hyposensitive to PHA767491-induced period lengthening. Together, our results reveal posttranslational modification of transcriptional repressors in plant clock TTFL by CK1 family proteins, which also modulate nonplant circadian clocks.
The circadian clock provides organisms with the ability to adapt to daily and seasonal cycles. Eukaryotic clocks mostly rely on lineage-specific transcriptional-translational feedback loops (TTFLs). Posttranslational modifications are also crucial for clock functions in fungi and animals, but the posttranslational modifications that affect the plant clock are less understood. Here, using chemical biology strategies, we show that the Arabidopsis CASEIN KINASE 1 LIKE (CKL) family is involved in posttranslational modification in the plant clock. Chemical screening demonstrated that an animal CDC7/CDK9 inhibitor, PHA767491, lengthens the Arabidopsis circadian period. Affinity proteomics using a chemical probe revealed that PHA767491 binds to and inhibits multiple CKL proteins, rather than CDC7/CDK9 homologs. Simultaneous knockdown of Arabidopsis CKL-encoding genes lengthened the circadian period. CKL4 phosphorylated transcriptional repressors PSEUDO-RESPONSE REGULATOR 5 (PRR5) and TIMING OF CAB EXPRESSION 1 (TOC1) in the TTFL. PHA767491 treatment resulted in accumulation of PRR5 and TOC1, accompanied by decreasing expression of PRR5- and TOC1-target genes. A prr5 toc1 double mutant was hyposensitive to PHA767491-induced period lengthening. Together, our results reveal posttranslational modification of transcriptional repressors in plant clock TTFL by CK1 family proteins, which also modulate nonplant circadian clocks.The circadian clock provides organisms with the ability to adapt to daily and seasonal cycles. Eukaryotic clocks mostly rely on lineage-specific transcriptional-translational feedback loops (TTFLs). Posttranslational modifications are also crucial for clock functions in fungi and animals, but the posttranslational modifications that affect the plant clock are less understood. Here, using chemical biology strategies, we show that the Arabidopsis CASEIN KINASE 1 LIKE (CKL) family is involved in posttranslational modification in the plant clock. Chemical screening demonstrated that an animal CDC7/CDK9 inhibitor, PHA767491, lengthens the Arabidopsis circadian period. Affinity proteomics using a chemical probe revealed that PHA767491 binds to and inhibits multiple CKL proteins, rather than CDC7/CDK9 homologs. Simultaneous knockdown of Arabidopsis CKL-encoding genes lengthened the circadian period. CKL4 phosphorylated transcriptional repressors PSEUDO-RESPONSE REGULATOR 5 (PRR5) and TIMING OF CAB EXPRESSION 1 (TOC1) in the TTFL. PHA767491 treatment resulted in accumulation of PRR5 and TOC1, accompanied by decreasing expression of PRR5- and TOC1-target genes. A prr5 toc1 double mutant was hyposensitive to PHA767491-induced period lengthening. Together, our results reveal posttranslational modification of transcriptional repressors in plant clock TTFL by CK1 family proteins, which also modulate nonplant circadian clocks.
Author Yamaguchi, Junichiro
Uehara, Takahiro N
Mizutani, Yoshiyuki
Mizoi, Junya
Hirota, Tsuyoshi
Yamaguchi-Shinozaki, Kazuko
Nishiwaki-Ohkawa, Taeko
Kay, Steve A
Ito, Shogo
Matsuo, Hiromi
Suzuki, Takamasa
Itami, Kenichiro
Kuwata, Keiko
Takao, Saori
Saito, Ami N
Yoshimura, Takashi
Kinoshita, Toshinori
Nakamichi, Norihito
Sato, Ayato
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  organization: Department of Chemistry, Graduate School of Science, Nagoya University, 464-8602 Nagoya, Japan
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  surname: Mizutani
  fullname: Mizutani, Yoshiyuki
  organization: Division of Biological Science, Graduate School of Science, Nagoya University, 464-8602 Nagoya, Japan
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  surname: Kuwata
  fullname: Kuwata, Keiko
  organization: Institute of Transformative Bio-Molecules, Nagoya University, 464-8601 Nagoya, Japan
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  surname: Hirota
  fullname: Hirota, Tsuyoshi
  organization: Japan Science and Technology Agency (JST) Precursory Research for Embryonic Science and Technology, 464-8602 Nagoya, Japan
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  organization: Department of Applied Biological Chemistry, Graduate School of Life and Agricultural Sciences, The University of Tokyo, 113-8657 Tokyo, Japan
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  organization: Institute of Transformative Bio-Molecules, Nagoya University, 464-8601 Nagoya, Japan
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  fullname: Matsuo, Hiromi
  organization: Institute of Transformative Bio-Molecules, Nagoya University, 464-8601 Nagoya, Japan
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  surname: Suzuki
  fullname: Suzuki, Takamasa
  organization: College of Bioscience and Biotechnology, Chubu University, 487-8501 Kasugai, Japan
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  givenname: Shogo
  surname: Ito
  fullname: Ito, Shogo
  organization: Department of Botany, Graduate School of Science, Kyoto University, 606-8502 Kyoto, Japan
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  givenname: Ami N
  surname: Saito
  fullname: Saito, Ami N
  organization: Department of Applied Chemistry, Waseda University, 169-8555 Tokyo, Japan
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  givenname: Taeko
  surname: Nishiwaki-Ohkawa
  fullname: Nishiwaki-Ohkawa, Taeko
  organization: Graduate School of Bioagricultural Sciences, Nagoya University, 464-8601 Nagoya, Japan
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  givenname: Kazuko
  surname: Yamaguchi-Shinozaki
  fullname: Yamaguchi-Shinozaki, Kazuko
  organization: Department of Applied Biological Chemistry, Graduate School of Life and Agricultural Sciences, The University of Tokyo, 113-8657 Tokyo, Japan
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  givenname: Takashi
  orcidid: 0000-0001-7018-9652
  surname: Yoshimura
  fullname: Yoshimura, Takashi
  organization: Graduate School of Bioagricultural Sciences, Nagoya University, 464-8601 Nagoya, Japan
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  givenname: Steve A
  orcidid: 0000-0002-0402-2878
  surname: Kay
  fullname: Kay, Steve A
  organization: Keck School of Medicine, University of Southern California, Los Angeles, CA 90033
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  givenname: Kenichiro
  surname: Itami
  fullname: Itami, Kenichiro
  organization: JST Exploratory Research for Advanced Technology, Itami Molecular Nanocarbon Project, Nagoya University, 464-8602 Nagoya, Japan
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  givenname: Toshinori
  surname: Kinoshita
  fullname: Kinoshita, Toshinori
  organization: Institute of Transformative Bio-Molecules, Nagoya University, 464-8601 Nagoya, Japan
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  givenname: Junichiro
  surname: Yamaguchi
  fullname: Yamaguchi, Junichiro
  email: junyamaguchi@waseda.jp, nnakamichi@itbm.nagoya-u.ac.jp
  organization: Department of Applied Chemistry, Waseda University, 169-8555 Tokyo, Japan; junyamaguchi@waseda.jp nnakamichi@itbm.nagoya-u.ac.jp
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  givenname: Norihito
  surname: Nakamichi
  fullname: Nakamichi, Norihito
  email: junyamaguchi@waseda.jp, nnakamichi@itbm.nagoya-u.ac.jp
  organization: Institute of Transformative Bio-Molecules, Nagoya University, 464-8601 Nagoya, Japan
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Keywords small molecule
Arabidopsis
circadian clock
posttranslational regulation
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Snippet The circadian clock provides organisms with the ability to adapt to daily and seasonal cycles. Eukaryotic clocks mostly rely on lineage-specific...
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SubjectTerms Arabidopsis - genetics
Arabidopsis Proteins - genetics
Casein Kinase I - genetics
Circadian Clocks - genetics
Circadian Rhythm - genetics
Gene Expression Regulation, Plant - genetics
Phosphorylation - genetics
Protein Processing, Post-Translational - genetics
Transcription Factors - genetics
Transcription, Genetic - genetics
Title Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock
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