Active uptake of dendritic cell-derived exovesicles by epithelial cells induces the release of inflammatory mediators through a TNF-alpha-mediated pathway

Dendritic cells (DCs) can release hundreds of membrane vesicles, called exovesicles, which are able to activate resting DCs and distribute antigen. Here, we examined the role of mature DC-derived exovesicles in innate and adaptive immunity, in particular their capacity to activate epithelial cells....

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Bibliographic Details

Published in:	The American journal of pathology Vol. 175; no. 2; p. 696
Main Authors:	Obregon, Carolina, Rothen-Rutishauser, Barbara, Gerber, Peter, Gehr, Peter, Nicod, Laurent P
Format:	Journal Article
Language:	English
Published:	United States 01.08.2009
Subjects:	Antigens, CD - metabolism CD40 Antigens - metabolism CD83 Antigen Dendritic Cells - immunology Dendritic Cells - metabolism Endocytosis - immunology Epithelial Cells - immunology Exosomes - metabolism Histocompatibility Antigens Class II - metabolism Humans Immunoglobulins - metabolism Inflammation Mediators - metabolism Membrane Glycoproteins - metabolism Tumor Necrosis Factor-alpha - metabolism
ISSN:	1525-2191, 1525-2191
Online Access:	Get more information
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