Shiga Toxin-Producing Escherichia coli (STEC) in Developing Countries: A 10-Year Review with Global Perspective

In the past two decades, Shiga toxin-producing Escherichia coli (STEC) has been responsible for multiple large-scale outbreaks worldwide, affecting thousands of individuals. While surveillance systems in developed countries such as the United States, the United Kingdom, Europe, Australia, Japan, and...

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Veröffentlicht in:Microorganisms (Basel) Jg. 13; H. 7; S. 1529
Hauptverfasser: Nemati, Ali, Dadvar, Ali, Eppinger, Mark, Karimpour, Zohreh, Saberi Kakhki, Soroush, Sabeti Moghaddam Sabzevar, Alireza, Badouei, Mahdi Askari, Gigliucci, Federica, Santos, Luis Fernando dos, Nakamura, Keiji, Javidi, Hooman, Hafiz, Maryam
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 30.06.2025
MDPI
Schlagworte:
Animals
Developed countries
Developing countries
Disease
E coli
Epidemics
Escherichia coli
Food
Food contamination & poisoning
Genes
human
Infections
Information management
LDCs
Medical Subject Headings-MeSH
Public health
Review
serogroup
serotype
Shiga toxin
Shiga toxin-producing Escherichia coli
STEC
Surveillance
Surveillance systems
Toxins
Virulence
Iran
United States
Europe
Japan
Egypt
Brazil
South Africa
United Kingdom
Nigeria
Ethiopia
India
developing countries
serogroup
STEC
animal
Shiga toxin-producing Escherichia coli
human
food
serotype
ISSN:2076-2607, 2076-2607
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Zusammenfassung:In the past two decades, Shiga toxin-producing Escherichia coli (STEC) has been responsible for multiple large-scale outbreaks worldwide, affecting thousands of individuals. While surveillance systems in developed countries such as the United States, the United Kingdom, Europe, Australia, Japan, and Canada are well-established, data on STEC prevalence in developing nations remain sparse, partly due to the absence of well-structured molecular diagnostic networks or surveillance systems. This review analyzed 250 studies published between 2014 and 2024 across 39 developing countries in Africa, Asia, Latin America, and the Caribbean, yielding 8986 STEC isolates. Detailed serogroup and serotype data were available for 55.9% of these, with O111, O157, and O26 being most common in humans. In animals, O157:H7 was most frequent, while food isolates mirrored global trends with O157 and O111 dominance. Notably, O145, a serogroup frequently reported in the U.S. and Europe, was absent from the ‘’Top Seven’’ serogroups. Shiga toxin subtypes stx1a and stx2a were most prevalent in human cases. In animal isolates, stx2e was the most prevalent subtype, while stx2c was most commonly found in food samples. We recommend establishing reference laboratories in these regions to improve data quality, strengthen monitoring efforts, and reduce the burden of STEC infections globally.
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ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms13071529