Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

Disrupting the costimulatory CD40-CD40L dyad reduces atherosclerosis, but can result in immune suppression. The authors recently identified small molecule inhibitors that block the interaction between CD40 and tumor necrosis factor receptor-associated factor (TRAF) 6 (TRAF-STOPs), while leaving CD40...

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Bibliographic Details
Published in:	Journal of the American College of Cardiology Vol. 71; no. 5; p. 527
Main Authors:	Seijkens, Tom T P, van Tiel, Claudia M, Kusters, Pascal J H, Atzler, Dorothee, Soehnlein, Oliver, Zarzycka, Barbara, Aarts, Suzanne A B M, Lameijer, Marnix, Gijbels, Marion J, Beckers, Linda, den Toom, Myrthe, Slütter, Bram, Kuiper, Johan, Duchene, Johan, Aslani, Maria, Megens, Remco T A, van 't Veer, Cornelis, Kooij, Gijs, Schrijver, Roy, Hoeksema, Marten A, Boon, Louis, Fay, Francois, Tang, Jun, Baxter, Samantha, Jongejan, Aldo, Moerland, Perry D, Vriend, Gert, Bleijlevens, Boris, Fisher, Edward A, Duivenvoorden, Raphael, Gerdes, Norbert, de Winther, Menno P J, Nicolaes, Gerry A, Mulder, Willem J M, Weber, Christian, Lutgens, Esther
Format:	Journal Article
Language:	English
Published:	United States 06.02.2018
Subjects:	Aniline Compounds - pharmacology Animals Atherosclerosis - pathology Atherosclerosis - prevention & control CD40 Ligand - antagonists & inhibitors Cell Culture Techniques Cell Movement - drug effects Disease Models, Animal Humans Macrophages - drug effects Mice Mice, Inbred C57BL Monocytes - drug effects Propiophenones - pharmacology Signal Transduction - drug effects TNF Receptor-Associated Factor 6 - antagonists & inhibitors atherosclerosis drug development nanotechnology inflammation immunology
ISSN:	1558-3597, 1558-3597
Online Access:	Get more information
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